原著論文(最近のものを抜粋)

  • Harumi Okuyama, Tomohito Hamazaki, Rokuro Hama, Yoichi Ogushi, Tetsuyuki Kobayashi, Naoki Ohara, Hajime Uchino (2018) A Critical Review of the Consensus Statement from the European Atherosclerosis Society Consensus Panel 2017. Pharmacology, 101: (3-4): 184-218.
  • Makino, A., Abe, M., Ishitsuka, R., Murate, M., Kishimoto, T., Sakai, S., Hullin-Matsuda, F., Shimada, Y., Inaba, T., Miyatake, H., Tanaka, H., Kurahashi, A., Pack, C.G., Kasai, R.S., Kubo, S., Schieber, N.L., Dohmae, N., Tochio, N., Hagiwara, K., Sasaki, Y., Aida, Y., Fujimori, F., Kigawa, T., Nishibori, K., Parton, R.G., Kusumi, A., Sako, Y., Anderluh, G., Yamashita, M., Kobayashi, T., Greimel, P., Kobayashi, T. (2017) A novel sphingomyelin/cholesterol domain-specific probe reveals the dynamics of the membrane domains during virus release and in Niemann-Pick type C. FASEB J., 31(4): 1301-1322.
  • Harumi Okuyama, Peter H Langsjoen, Naoki Ohara, Yoko Hashimoto, Tomohito Hamazaki, Satoshi Yoshida, Tetsuyuki Kobayashi and Alena M. Langsjoen (2016). Medicines and Vegetable Oils as Hidden Causative of Cardiovascular Disease and Diabetes. Pharmacology, 98: 134-170.
  • Remi Murase, Hiroyasu Sato, Kei Yamamoto, Ayako Ushida, Yasumasa Nishito, Kazutaka Ikeda, Tetsuyuki Kobayashi, Toshinori Yamamoto, Yoshitaka Taketomi, and Makoto Murakami (2016) Group X Secreted Phospholipase A2 Releases ω3 Polyunsaturated Fatty Acids to Suppress Colitis and Promote Sperm Fertility. J. Biol. Chem., 291 (13): 6895-6911.
  • Remi Murase, Hiroyasu Sato, Kei Yamamoto, Ayako Ushida, Yasumasa Nishito, Kazutaka Ikeda, Tetsuyuki Kobayashi, Toshinori Yamamoto, Yoshitaka Taketomi, Makoto Murakami (2016) Group X Secreted Phospholipase A2 Releases omega-3 Polyunsaturated Fatty Acids, Suppresses Colitis and Promotes Sperm Fertility. J. Biol. Chem., 291 (13): 6895-6911.
  • Saori Mikami, Junichi Aiboshi, Tetsuyuki Kobayashi,　Mitsuaki Kojima, Koji Mirishita, and Yasuhiro Otomo (2015) Discrete Roles of Intracellular Phospholipase A2 in Human Neutrophil Cytotoxicity. J. Trauma and Acute Care Surgery,　79 (2): 238-246.
  • Harumi Okuyama, Peter H. Langsjoen, Tomohito Hamazaki, Yoichi Ogushi, Rokuro Hama, Tetsuyuki Kobayashi and Hajime Uchino (2015) Statins Stimulate Atherosclerosis and Heart Failure- pharmacological mechanisms. Expert Review in Clinical Pharmacology, 8(2): 189-199.
  • Mitsuaki Kojima, Junichi Aiboshi, Masahiro Shibata, Tetsuyuki Kobayashi, and Yasuhiro Otomo (2015) Novel role of group VIB Ca2+-dependent phospholipase A2γ in leukocyte-endotherial cell interaction in acute inflammation: an intravital microscopic study in rat mesentery. J. Trauma and Acute Care Surgery,　79 (5): 782-789.
  • Hiroyasu Sato, Yoshitaka Taketomi, Ayako Ushida, Yuki Isogai, Takumi Kojima, Tetsuya Hirabayashi, Yoshimi Miki, Kei Yamamoto, Yasumasa Nishito, Tetsuyuki Kobayashi, Kazutaka Ikeda, Ryo Taguchi, Shuntaro Hara, Satoshi Ida, Yuji Miyamoto, Masayuki Watanabe, Hideo Baba, Keishi Miyata, Yuichi Oike, Michael H. Gelb, Makoto Murakami (2014) The Adipocyte-Inducible Secreted Phospholipases PLA2G5 and PLA2G2E Play Distinct Roles in Obesity. Cell Matabolism, 20: 119-132.
  • Chie Shimamoto, Tetsuo Ohnishi, Motoko Maekawa, Akiko Watanabe, Hisako Ohba, Ryoichi Arai, Yoshimi Iwayama, Yasuko Hisano, Tomoko Toyota, Manabu Toyoshima, Katsuaki Suzuki, Yukihiko Shirayama, Kazuhiko Nakamura, Norio Mori, Yuji Owada, Tetsuyuki Kobayashi and Takeo Yoshikawa (2014) Functional characterization of FABP3, 5 and 7 gene variants identified in schizophrenia and autism spectrum disorder and mouse behavioral studies. Human Molecular Genetics, 23(24), 6495-651.
  • Yoshimi Miki, Kei Yamamoto, Yoshitaka Taketomi, Hiroyasu Sato, Kanako Shimo, Tetsuyuki Kobayashi, Yukio Ishikawa, Toshiharu Ishii, Hiroki Nakanishi, Kazutaka Ikeda, Ryo Taguchi, Kenji Kabashima, Makoto Arita, Hiroyuki Arai, Gérard Lambeau, James Bollinger, Shuntaro Hara, Michael Gelb, and Makoto Murakami (2013) Lymphoid Tissue Phospholipase A2 Group IID Resolves Contact Hypersensitivity by Driving Anti-Inflammatory Lipid Mediators. J. Exp. Med., 210(6): 1217-1234.
  • Koji Morishita, Junichi Aiboshi, Tetsuyuki Kobayashi, Yuri Yokoyama, Saori Mikami, Jiro Kumagai, and Yasuhiro Otomo (2013) Group VIB Ca 2+-independent phospholipase A2γ is associated with acute lung injury following trauma and hemorrhagic shock. J.Trauma and Acute Care Surg., 75 (5): 767-774.
  • Koji Morishita, Junichi Aiboshi, Tetsuyuki Kobayashi, Saori Mikami, Yuri Yokoyama, Kaori Ogawa, Hiroyuki Yokota, and Yasuhiro Otomo (2012) Lipidomics analysis of mesenteric lymph after trauma and hemorrhagic shock. J. Trauma Acute Care Surg., 72 (6): 1541-1547.
  • Junichi Ikenouchi, Mayu Suzuki, Kazuaki Umeda, Kazutaka Ikeda, Ryo Taguchi, Tetsuyuki Kobayashi, Satoshi B. Sato, Toshihide Kobayashi, Donna B. Stolz, and Masato Umeda (2012). Lipid polarity is maintained in absence of tight junctions. J. Biol. Chem., 287(12): 9525-9533.
  • Hiroyasu Sato, Yuki Isogai, Seiko Masuda, Yoshitaka Taketomi, Yoshimi Miki1, Daisuke Kamei, Shuntaro Hara, Tetsuyuki Kobayashi, Yukio Ishikawa, Toshiharu Ishii, Kazutaka Ikeda, Ryo Taguchi, Yoshikazu Ishimoto, Noriko Suzuki, Yasunori Yokota, Kohji Hanasaki, Toshiko Yamamoto, Kei Yamamoto, and Makoto Murakami (2011) Physiological Roles of Group X Secreted Phospholipase A2 in Reproduction, Gastrointestinal Phospholipid Digestion, and Neuronal Function. J. Bol. Chem., 286 (13): 11632-11648.
  • Kei Yamamoto, Yoshitaka Taketomi, Yuki Isogai, Yoshimi Miki, Hiroyasu Sato, Mitsuhiro Ohtsuki, Seiko Masuda, Yasumasa Nishito, Kiyokazu Morioka, Yoshikazu Ishimoto, Noriko Suzuki, Yasunori Yokota, Kohji Hanasaki, Yukio Ishikawa, Toshiharu Ishii, Tetsuyuki Kobayashi, Kiyoko Fukami, Kazutaka Ikeda, Hiroki Nakanishi, Ryo Taguchi, and Makoto Murakami (2011) Hair Follicular Expression and Function of Group X Secreted Phospholipase A2 in Mouse Skin. J. Bol. Chem., 286 (13): 11616-11631.
  • Hideko Tanaka and Tetsuyuki Kobayashi (2011) Characterization of a 62-Kilodalton Acidic Phospholipid-Binding Protein Isolated from the Edible Mushroom Pleurotus ostreatus. J. Health Sci., 57 (1), 99-106.
  • Hiroyasu Sato, Yoshitaka Taketomi, Yuki Isogai, Yoshimi Miki, Kei Yamamoto, Tomohiko Hosono, Satoru Arata, Yukio Ishikawa, Toshiharu Ishii, Tetsuyuki Kobayashi, Hiroki Nakanishi, Kazutaka Ikeda, Ryo Taguchi, Shuntaro Hara, Ichiro Kudo, and Makoto Murakami (2010) Group III Secreted Phospholipase A2 Regulates Epididymal Sperm Maturation and Fertility. J. Clin. Invest., 120(5): 1400-1414.
  • Tamotsu Tsukahara, Ryoko Tsukahara, Yuko Fujiwara, Junming Yue, Yunhui Cheng, Huazhang Guo, Chunxiang Zhang,　Louisa Balazs,　Fabio Re , Guangwei Du, Michael A. Frohman, Daniel L. Baker, Abby L. Parrill, Ayako Uchiyama, Tetsuyuki Kobayashi,　Kimiko Murakami-Murofushi, Gabor　Tigyi (2010) Phospholipase D2-dependent Inhibition of the Nuclear Hormone Receptor PPARγby Cyclic Phosphatidic Acid. Molecular Cell., 36, 421-432.
  • Ayako Uchiyama, Yukari Arai, Tetsuyuki Kobayashi, Gabor Tigyi and Kimiko Murakami-Murofushi　 (2010) Transcellular invasion of MM1 rat ascites hepatoma cells requires matrix metalloproteinases derived from host mesothelium. Cytologia., 75, 269-272.
  • Tamotsu Tsukahara, Shuwa Hanazawa, Tetsuyuki Kobayashi, and Kimiko Murakami-Murofushi (2010) Cyclic Phosphatidic Acid Decreases Proliferation and Survival of Colon Cancer Cells through Inhibition of Peroxisome Proliferator-activated Receptor gamma. Prostaglandins, Other Lipid Mediat., 93 (3-4), 126-133.
  • Masako Fukushima,Emiko Takeyama,Seigo Shiga,Masao Takeuchi and Tetsuyuki Kobayashi (2010) Dietary intake of green nut oil decreases levels of oxidative stress biomarkers. J. Lipid Nutr., 19 (1): 111-119.
  • Hiroyasu Sato, Yoshitaka Taketomi, Yuki Isogai, Seiko Masuda, Tetsuyuki Kobayashi, Kei Yamamoto, and Makoto Murakami (2009) Group III Secreted Phospholipase A2 Transgenic Mice Spontaneously Develop Inflammation. Biochem. J., 421 (1): 17-27.
  • Hiroyasu Sato, Rina Kato, Yuki Isogai, Go-ichi Saka, Mitsuhiro Ohtsuki, Yoshitaka Taketomi, Kei　Yamamoto, Kae Tsutsumi, Joe Yamada, Seiko Masuda, Yukio Ishikawa, Toshiharu Ishii, Tetsuyuki Kobayashi, Kazutaka Ikeda, Ryo Taguchi, Shinji Hatakeyama, Shuntaro Hara, Ichiro Kudo, Hiroyuki Itabe, and Makoto　Murakam (2008) Analyses of Group III Secreted Phospholipase A2 Transgenic Mice Reveals Potential Participation　of This Enzyme in Plasma Lipoprotein Modification, Macrophage Foam Cell Formation, and　Atherosclerosis. J. Biol. Chem., 283 (48): 33483-33497.
  • Ayako Uchiyama, Mutsuko Mukai, Yuko Fujiwara, Susumu Kobayashi, Nobuyuki Tetsuyuki Kobayashi (2007) Apple Polyphenols Have an Influence on Fat Metabolism in Healthy Subjects with Relatively High Body Mass Index. Biochim.Biophys. Acta, 1771: 103-112.
  • Yoko Nagasako-Akazome, Tomomasa Kanda, Yasuyuki Ohtake, Hiroyuki Shimasaki and Tetsuyuki Kobayashi (2007)　Apple Polyphenols Have an Influence on Fat Metabolism in Healthy Subjects with Relatively High Body Mass Index. J. Oleo Sci., 56 (8): 417-428.
  • Satomi Tsuda, Shinichi Okudaira, Keiko Moriya-Ito, Chie Shimamoto, Masayuki Tanaka, Junken Aoki, Hiroyuki Arai, Kimiko Murakami-Murofushi, and Tetsuyuki Kobayashi (2006) Cyclic phosphatidic acid is produced by autotaxin in blood. J. Biol. Chem.281, 26081 – 26088
  • Yuki Shirai, Narie Sasaki, Yoshiro Kishi, Akiko Izumi, Kie Itoh, Masazumi Sameshima, Tetsuyuki Kobayashi, and Kimiko Murakami-Murofushi (2006) Regulation of levels of actin threonine phosphorylation during life cycle of Physarum polycephalum. Cell Motil. Cytoskeleton63, 77-87
  • Keiko Moriya-Ito Toshiya Osada, Yuuki Ishimatsu, Kazuyo Muramoto, Testuyuki Kobayashi, and Masumi Ichikawa (2005) Maturation of vomeronasal receptor neurons in vitro by coculture with accessory olfactory bulb neurons. Chem. Senses 30, 111-119
  • Yuko Fujiwara, Agnes Sebok, Susan Meakin, Tetsuyuki Kobayashi, Kimiko Murakami-Murofushi, Gabor Tigyi (2003) Cyclic-phosphatidic acid elicits the neurotrophin-like actions in embryonic hippocampal neurons. J. Neurochem. 87, 1272-1283
  • Shoko Kunimoto, Wataru Murofushi, Isao Yamatsu, Yukie Hasegawa, Narie Sasaki, Susumu Kobayashi, Tetsuyuki Kobayashi, Hiromu Murofushi, and Kimiko Murakami-Murofushi (2003) Cholesteryl Glucoside-induced protection against gastric ulcer. Cell Struct. Funct.28, 179-186
  • Takamitsu Sano, Daniel Baker, Tamas Virag, Atsushi Wada, Yutaka Yatomi, Tetsuyuki Kobayashi, Yasuyuki Igarashi, Gabor Tigyi (2002) Multiple Mechanisms Linked to Platelet Activation Result in Lysophosphatidic Acid and Sphingosine-1-Phosphate Generation in Blood. J. Biol. Chem. 277, 21197-21206
  • Birei Furuta, Ayako Harada, Yoko Kobayashi1, Ken-ichi Takeuchi, Tetsuyuki Kobayashi, and Masato Umeda (2002) Identification and Functional Characterization of Nadrin Variants,a Novel Family of GTPase Activating Protein for Rho GTPases. J. Neurochem. 82, 1018-1028
  • Kimiko Murakami-Murofushi, Ayako Uchiyama, Yuko Fujiwara, Tetsuyuki Kobayashi, Susumu Kobayashi, Mutsuko Mukai, Hiromu Murofushi, and Gabor Tigyi (2002) Biological Functions of a Novel Lipid Mediator, Cyclic Phosphatidic Acid (cPA). Biochim. Biophys. Acta 1582, 1-7
  • Toshihide Kobayashi, Marie-Helene Beuchat, Julien Chevallier, Asami Makino,Tetsuyuki Kobayashi, and Jean Gruenberg (2002) Membrane domains in the late endocytic pathway. J. Biol. Chem. 277, 32157-32164
  • Utako Kato, Kazuo Emoto, Charlotta Fredriksson, Hidemitsu Nakamura, Akinori Ohta, Toshihide Kobayashi, Kimiko Murakami-Murofushi, Tetsuyuki Kobayashi, and Masato Umeda (2002) Ros3p, a Membrane Protein Associated with Lipid Rafts, is Required for Phospholipid Translocation across the Plasma Membrane in Saccharomyces cerevisiae. J. Biol. Chem.277, 37855-37862
  • Shohko Kunimoto, Wataru Murofushi, Hirofumi Kai, Yoko Ishida, Ayako Uchiyama, Tetsuyuki Kobayashi, Susumu Kobayashi, Hiromu Murofushi, and Kimiko Murakami-Murofushi (2002) Steryl glucoside is a lipid mediator in stress-responsive signal transduction. Cell Struct. Funct. 27, 157-162
  • Tetsuyuki Kobayashi and Kimiko Murakami-Murofushi. (2001) Bioactions and Synthesis of a Novel Lipid Mediator, Cyclic Phosphatidic Acid (cPA). World Rev. Nutr. Diet. 88, 228-232
  • Shohko Kunimoto, Tetsuyuki Kobayashi and Kimiko Murakami-Murofushi(2000) Expression of cholesteryl glucoside by heat shock in human fibroblasts. Cell Stress Chaperones 5, 3-7
  • Miyuki Kato, Yoshitaka Nagata, Akiko Tanabe, Atsushi Ikemoto, Shiro Watanabe, Tetsuyuki Kobayashi, Yoichi Fujii, and Harumi Okuyama (2000) Supplementary treatment of atopic dermatitis patients by choosing foods to lower the N-6/N-3 ratio of fatty acids. J. Health Sci.46, 241-250
  • Satoshi Yasuda, Shiro Watanabe, Tetsuyuki Kobayashi, Noriaki Hata, Yoshihisa Misawa, Hideo Utsumi and Harumi Okuyama (1999) Dietary docosahexaenoic acid enhances ferric nitrilotriacetate-induced oxidative damage in mice but not when additional α-tocopherol is supplemented. FreeRad. Res.30, 199-205
  • Atsushi Ikemoto, Tetsuyuki Kobayashi, Kazuo Emoto, Masato Umeda, Shiro Watanabe, and Harumi Okuyama (1999) Effects of docosahexaenoic and arachidonic acids on the synthesis and distribution of aminophospholipids during neuronal differentiation of PC12 cells.Arch. Biochem. Biophys. 364, 67-74
  • Akira Sato, Tomomi Osakabe, Atsushi Ikemoto, Shiro Watanabe, Tetsuyuki Kobayashi and Harumi Okuyama (1999) Long-term n-3 fatty acid deficiency induces no substantial changes in the rate of protein synthesis in rat brain and liver. Biol. Pharm. Bull.22, 775-779
  • Tetsuyuki Kobayashi, Rieko Tanaka-Ishii, Ryo Taguchi, Hiroh Ikesawa and Kimiko Murakami-Murofushi (1999) Existence of a bioactive lipid, cyclic phosphatidic acid, bound to human serum albumin. Life Sci. 65, 2185-2191
  • Koji Bandoh, Junken, Aoki, Hiroyuki Hosono, Susumu Kobayashi, Tetsuyuki Kobayashi, Kimiko Murakami-Murofushi, Masafumi Tsujimoto, Hiroyuki Arai and Keizo Inoue (1999) Molecular cloning and characterization of a novel human G-protein-coupled receptor, EDG7, for lysophosphatidic acid. J. Biol. Chem. 274, 27776-27785
  • Kentaro Oh-hashi, Tetsuya Takahashi, Shiro Watanabe, Tetsuyuki Kobayashi and Harumi Okuyama, Noriaki Hata and Yoshihisa Misawa (1998) Effect of replacing a high linoleate oil with a low linoleate, high α-linolenate oil as compared with supplementing EPA or DHA on reducing lipid mediator production in rat polymorphonuclear leukocytes. Biol. Pharm. Bull.21, 558-564
  • Makoto Miyazaki, Min-Zhao Huang, Shiro Watanabe, Tetsuyuki Kobayashi and Harumi Okuyama (1998) Early mortality effect of partially hydrogenated vegetable oils in stroke-prone hypertensive rats (SHRSP). Nutr. Res.18, 1049-1056
  • Shiro Watanabe, Tetsuyuki Kobayashi and Harumi Okuyama (1998) Absence of relation between the expression of cyclooxygenese isoforms and the synthesis of prostaglandin E2 in resident and thioglycollate-elicited macrophages in rats. Prostaglandins & other Lipid Mediators56, 7-18
  • Satoshi Yasuda, Shiro Watanabe, Tetsuyuki Kobayashi and Harumi Okuyama (1998) Effects of dietary fatty acid and chronic carbon tetrachloride treatment on the accumulation of oxidation products, α-tocopherol and liver injury in mice. Biol. Pharm. Bull.21, 1050-1056
  • Tetsuyuki Kobayashi,Tetsuya Simizukawa, Tomomi Osakabe, Shiro Watanabe, and Harumi Okuyama (1997) A long-term feeding of sphingolipids affected the levels of plasma cholesterol and hepatic triacylglycerol but not tissue phospholipids and sphingolipids. Nutrition Res.17, 111-114
  • Shiro Watanabe, Chie Yoshida, Tetsuyuki Kobayashi and Harumi Okuyama (1997) An enzyme immunoassay for prostaglandin E2using Biotin-prostaglandin B2 conjugate as a tracer. Biol. Pharm. Bull. 20, 101-103
  • Satoshi Yoshida, A. Yasuda, H. Kawazato, K. Sakai, T. Shimada, Masazumi Takeshita, Shu Yuasa, Tetsuyuki Kobayashi, Shiro Watanabe and Harumi Okuyama (1997) Synaptic vesicle ultrastructural changes in the rat hippocampus induced by a combination of α-linolenate deficiency and learning task. J. Neurochem. 68, 1261-1268
  • Satoshi Yoshida, Mari Miyazaki, Masazumi Takeshita, Shu Yuasa, Tetsuyuki Kobayashi, Shiro Watanabe and Harumi Okuyama (1997) Functional changes of rat brain microsomal membrane surface after learning task depending on dietary fatty acids. J. Neurochem.68, 1269-1277
  • Masaru Minami, Shin-ichiro Kimura, Toru Endo, Naoya Hamaue, Masahiko Hirafuji, Yoshio Monma, Hiroko Togashi, Mitsuhiro Yoshioka, Hideya Saito, Shiro Watanabe, Tetsuyuki Kobayashi and Harumi Okuyama (1997) Effects of dietary docosahexaenoic acid (DHA) on survival time and the stroke-related behavior in stroke-prone spontaneously hypertensive rats (SHRSP). General Pharmacol. 29, 401-407
  • Kentaro Oh-hashi, Shiro Watanabe, Tetsuyuki Kobayashi and Harumi Okuyama (1997) Reevaluation of the effect of a highα-linolenate and a high linoleate diet on antigen-induced antibody and anaphylactic responses in mice. Biol. Pharm. Bull. 20, 217-223
  • Atsushi Ikemoto, Tetsuyuki Kobayashi, Shiro Watanabe and Harumi Okuyama (1997) Membrane fatty acid modifications of PC12 cells by arachidonate or docosahexaenoate affect neurite outgrowth but not norepinephrine release. Neurochem. Res. 22, 671-678
  • Satoshi Yoshida, M. Miyazaki, K. Sakai, Masazumi Takeshita, Shu Yuasa, Tetsuyuki Kobayashi, Shiro Watanabe and Harumi Okuyama (1997) Fourier-transform infrared spectroscopic analysis of rat brain microsomal membranes modified by dietary fatty acids: Possible correlations with altered learning behavior. Biospectroscopy 3, 281-290
  • Min-Zhao Huang, Shiro Watanabe, Tetsuyuki Kobayashi, Akito Nagatsu, Jinsaku Sakakibara and Harumi Okuyama (1997) Unusual effects of some vegetable oils on the survival time of stroke-prone spontaneously hypertensive rats. Lipids32, 745-751
  • Masaru Minami, Shin-ichiro Kimura, Toru Endo, Naoya Hamaue, Masahiko Hirafuji, Hiroko Togashi, M. Matsumoto, M. Yoshioka, Hideya Saito, Shiro Watanabe, Tetsuyuki. Kobayashi and Harumi Okuyama (1997) Dietary docosahexaenoic acid increases cerebral acetylcholine levels and passive avoidance performance of stroke-prone spontaneously hypertensive rats (SHRSP). Pharmacol. Biochem. Behavior58, 1123-1129
  • Satoshi Yasuda, Shiro Watanabe, Tetsuyuki Kobayashi and Harumi Okuyama (1997) Docosahexaenoic acid-rich fish oil does not enhance the elevation of serum transaminase and liver triacylglycerol induced by carbon tetrachloride in mice. Lipids 32, 1249-1255
  • Kentaro Oh-hashi, Tetsuya Takahashi, Shiro Watanabe, Tetsuyuki Kobayashi and Harumi Okuyama (1997) Possible mechanisms for the differential effects of high linoleate safflower oil and high α-linolenate perilla oil diets on platelet-activating factor production by rat polymorphonuclear leukocytes. J. Lipid Mediators Cell Signalling17, 207-220