Laboratory of Computational Biology

This laboratory studies biological phenomena in the molecular level using computer only. The members in the laboratory use and develop methods to analyze genome sequences, RNA sequences, amino acid sequences, protein structures, biological supramolecular structure and so forth and unveil the wonder of biology. Those who would like to develop a computational data analysis method, or who would like to apply existing methods to new data are all welcome to this laboratory. Those who have experimental data that is difficult to analyze but who are keen on applying a  computational method are welcome as well. This lab welcomes a collaborative research as long as the lab capacity allows.

This laboratory belongs to the Department of Biology in the Faculty of Science. But students in any department (biology, chemistry, information science, and physics) can choose this lab for the graduation research. Anyone who wants to study in this lab needs to know what DNA, RNA, and protein are in advance, but enthusiasm can outperform a shallow knowledge.

The main research area of the lab is (1) pre-translational post-transcriptional computational biology and (2) computational biology of DNA damage repair.

(1) RNA transcribed from the genome sequence comes to function after being fabricated. The study aims to identify how the RNA is processed.

(2) The fundamental and molecular process of biological evolution is a change in DNA sequence including DNA damage. All organisms have mechanisms to repair DNA damage, but if this repair mechanism functions perfectly, there is no evolution. This study aims to find the balancing mechanism between perfect repair and tolerance for evolution.

Other seemingly unrelated research are also going on in the lab and hence the progress of those research is not steady. The lab often jumps to an interesting hot topic that is brought by a new comer. We tackle various issues considered important for understanding mechanisms of life.

The entrance exam for the graduate school will be held in summer(Aug.) and winter(Feb.). For those of you who want to stay temporarily (eg. two-month internship) in this lab to get the feeling of the field and the lab, contact Prof. Kei Yura (Edit the Email address).