論文・総説 | Articles & Reviews

2024

• A small-molecule degron with a phenylpropionic acid scaffold 
  Shusuke Tomoshige*, Fumiko Komatsu, Tomoko Kikuchi, Miku Sugiyama, Yushi Kawasaki, Kenji Ohgane, Yuuki Furuyama, Shinichi Sato, Minoru Ishikawa, Kouji Kuramochi
  Bioorganic & Medicinal Chemistry 109, 117789-117789 2024年6月

2023

• Lysine long-chain fatty acylation regulates the TEAD transcription factor
  Kota Noritsugu, Takehiro Suzuki, Kosuke Dodo, Kenji Ohgane, Yasue Ichikawa, Kota Koike, Satoshi Morita, Takashi Umehara, Kenji Ogawa, Mikiko Sodeoka, Naoshi Dohmae, Minoru Yoshida*, Akihiro Ito*
  Cell Reports 42, 112388, 2023年4月 (Open Access)
  DOI: 10.1016/j.celrep.2023.112388
  
  

2022

• Fine-tuning of nitrogen-containing bisphosphonate esters that potently induce degradation of HMG-CoA reductase
  Kota Kawamura, Hiromasa Yoshioka, Chikako Sato, Tomoko Yajima, Yuuki Furuyama, Kouji Kuramochi, Kenji Ohgane*
  Bioorg Med Chem 78, 117145, 2022年12月
  DOI: 10.1016/j.bmc.2022.117145
  Preprint (SSRN): https://ssrn.com/abstract=4285357
  
• Synthesis and cytotoxic activities of 8-and 6-demethyleucalyptins

  Ryuki Asakawa, Kanta Fuchiyama, Yunosuke Ishii, Keisuke Hosaka, Atsushi Kobayashi, Kei Shimazaki, Junki Nagasawa, Sayaka Tsuchida, Kazunari Ushida, Makoto Matsubayashi, Yuuki Furuyama, Kenji Ohgane, Kouji Kuramochi*

  BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 86(9) 1200-1206 2022年8月24日
• Conversion of a PROTAC Mutant Huntingtin Degrader into Small-Molecule Hydrophobic Tags Focusing on Drug-like Properties
  Keigo Hirai, Hiroko Yamashita, Shusuke Tomoshige*, Yugo Mishima, Tatsuya Niwa, Kenji Ohgane, Mayumi Ishii, Kayoko Kanamitsu, Yui Ikemi, Shinsaku Nakagawa, Hideki Taguchi, Shinichi Sato, Yuichi Hashimoto, and Minoru Ishikawa*
  ACS Medicinal Chemistry Letters 13(3), 396-402, 2022年2月
  DOI: 10.1021/acsmedchemlett.1c00500
  
• Synthesis and Antiviral Activities of Neoechinulin B and Its Derivatives.
  Kota Nishiuchi, Hirofumi Ohashi, Kazane Nishioka, Masako Yamasaki, Masateru Furuta, Takumi Mashiko, Shusuke Tomoshige, Kenji Ohgane, Shinji Kamisuki, Koichi Watashi, Kouji Kuramochi*
  Journal of Natural Products 85, 284–291, 2022年1月28日

2021

• Deuteration of terminal alkynes realizes simultaneous live cell Raman imaging of similar alkyne-tagged biomolecules.
  Syusuke Egoshi, Kosuke Dodo, Kenji Ohgane, Mikiko Sodeoka
  Organic & Biomolecular Chemistry 19(38) 8232-8236 2021年9月
• Deoxygenation of tertiary and secondary alcohols with sodium borohydride, trimethylsilyl chloride, and potassium iodide in acetonitrile
  Yuichi Kato, Tomoka Inoue, Yuuki Furuyama, Kenji Ohgane, Mahito Sadaie, Kouji Kuramochi
  TETRAHEDRON LETTERS 86 2021年12月
• Epo-C12 inhibits peroxiredoxin 1 peroxidase activity.
  Tomoka Yoda, Masateru Furuta, Tomohiko Tsutsumi, Seiki Ikeda, Shunsuke Yukizawa, Satoshi Arai, Akinori Morita, Kenji Yamatoya, Kazuya Nakata, Shusuke Tomoshige, Kenji Ohgane, Yuuki Furuyama, Kengo Sakaguchi, Fumio Sugawara, Susumu Kobayashi, Masahiko Ikekita, Kouji Kuramochi
  Bioorganic & medicinal chemistry 41 116203-116203 2021年7月1日

2020

• Image-based screen capturing misfolding status of Niemann-Pick type C1 identifies potential candidates for chaperone drugs
  Ryuta Shioi, Fumika Karaki, Hiromasa Yoshioka, Tomomi Noguchi-Yachide, Minoru Ishikawa, Kosuke Dodo, Yuichi Hashimoto, Mikiko Sodeoka, Kenji Ohgane*
  PLOS ONE 15(12) e0243746-e0243746 2020年12月14日
• Bisphosphonate esters interact with HMG-CoA reductase membrane domain to induce its degradation
  Yosuke Toyota, Hiromasa Yoshioka, Ikuya Sagimori, Yuichi Hashimoto, Kenji Ohgane*
  Bioorganic & Medicinal Chemistry 28(14) 115576-115576 2020年5月
• A key mammalian cholesterol synthesis enzyme, squalene monooxygenase, is allosterically stabilized by its substrate
  Hiromasa Yoshioka, Hudson W. Coates, Ngee Kiat Chua, Yuichi Hashimoto, Andrew J. Brown*, Kenji Ohgane*
  Proceedings of the National Academy of Sciences 117(13) 7150-7158 2020年3月31日
• Luciferase-based HMG-CoA reductase degradation assay for activity and selectivity profiling of oxy(lano)sterols
  Ikuya Sagimori, Hiromasa Yoshioka, Yuichi Hashimoto, Kenji Ohgane*
  Bioorganic & Medicinal Chemistry 28(3) 115298-115298 2020年2月

2019

• Application of Protein Knockdown Strategy Targeting β-Sheet Structure to Multiple Disease-associated Polyglutamine Proteins
  Hiroko Yamashita, Shusuke Tomoshige, Sayaka Nomura, Kenji Ohgane, Yuichi Hashimoto, Minoru Ishikawa*
  Bioorganic & Medicinal Chemistry 28(1) 115175 2019年10月
• Structure-activity relationship study of estrogen receptor down-regulators with a diphenylmethane skeleton.
  Nanjyo S, Ohgane K, Yoshioka H, Makishima M, Hashimoto Y, Noguchi-Yachide T*
  Bioorganic & medicinal chemistry 27(10) 1952-1961 2019年5月
• Multiplexing fluorogenic esterase-based viability assay with luciferase assays
  Kenji Ohgane*, Hiromasa Yoshioka, Yuichi Hashimoto
  MethodsX 6 2013-2020 2019年

2018

• Degradation of huntingtin mediated by a hybrid molecule composed of IAP antagonist linked to phenyldiazenyl benzothiazole derivative
  Shusuke Tomoshige, Sayaka Nomura, Kenji Ohgane, Yuichi Hashimoto, Minoru Ishikawa*
  Bioorganic and Medicinal Chemistry Letters 28(4) 707-710 2018年2月15日
• Unexpected emergence of luciferase-inhibitory activity during structural development study of phenyloxadiazole-based PPAR ligands
  Shioi R, Toyota Y, Noguchi-Yachide T, Ishikawa M, Yamaguchi T, Makishima M, Hashimoto Y, Ohgane K*
  Heterocycles 97(2) 854-864 2018年

2017

• Discovery of Small Molecules that Induce the Degradation of Huntingtin
  Shusuke Tomoshige, Sayaka Nomura, Kenji Ohgane, Yuichi Hashimoto, Minoru Ishikawa
  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 56(38) 11530-11533 2017年9月
• Reactivity of 7-Azanorbornenes in Bioorthogonal Inverse Electron-Demand Diels-Alder Reactions
  Fumika Karaki, Kenji Ohgane, Hirotaka Imai, Kennosuke Itoh, Hideaki Fujii
  EUROPEAN JOURNAL OF ORGANIC CHEMISTRY 2017(26) 3815-3829 2017年7月
• Phenanthridin-6-one derivatives as the first class of non-steroidal pharmacological chaperones for Niemann-Pick disease type C1 protein
  Hiromitsu Fukuda, Fumika Karaki, Kosuke Dodo, Tomomi Noguchi-Yachide, Minoru Ishikawa, Yuichi Hashimoto, Kenji Ohgane
  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 27(12) 2781-2787 2017年6月

2014

• Structure-activity relationships of oxysterol-derived pharmacological chaperones for Niemann-Pick type C1 protein
  Kenji Ohgane, Fumika Karaki, Tomomi Noguchi-Yachide, Kosuke Dodo, Yuichi Hashimoto
  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 24(15) 3480-3485 2014年8月
• Structure-activity relationship study of non-steroidal NPC1L1 ligands identified through cell-based assay using pharmacological chaperone effect as a readout
  Fumika Karaki, Kenji Ohgane, Hiromitsu Fukuda, Masahiko Nakamura, Kosuke Dodo, Yuichi Hashimoto
  BIOORGANIC & MEDICINAL CHEMISTRY 22(14) 3587-3609 2014年7月

~2013

• Structure-activity relationship studies of Niemann-Pick type C1-like 1 (NPC1L1) ligands identified by screening assay monitoring pharmacological chaperone effect
  Fumika Karaki, Kenji Ohgane, Kosuke Dodo, Yuichi Hashimoto
  BIOORGANIC & MEDICINAL CHEMISTRY 21(17) 5297-5309 2013年9月
• Discovery of Oxysterol-Derived Pharmacological Chaperones for NPC1: Implication for the Existence of Second Sterol-Binding Site
  Kenji Ohgane, Fumika Karaki, Kosuke Dodo, Yuichi Hashimoto
  CHEMISTRY & BIOLOGY 20(3) 391-402 2013年3月
• Design, Synthesis, and Biological Evaluation of Novel Transrepression-Selective Liver X Receptor (LXR) Ligands with 5,11-Dihydro-5-methyl-11-methylene-6H-dibenz[b,e]azepin-6-one Skeleton
  Atsushi Aoyama, Kaori Endo-Umeda, Kenji Kishida, Kenji Ohgane, Tomomi Noguchi-Yachide, Hiroshi Aoyama, Minoru Ishikawa, Hiroyuki Miyachi, Makoto Makishima, Yuichi Hashimoto
  JOURNAL OF MEDICINAL CHEMISTRY 55(17) 7360-7377 2012年9月
• Bidirectional fluorescence properties of pyrene-based peroxisome proliferator-activated receptor (PPAR) α/δ dual agonist.
  Ban Shintaro, Oyama Takuji, Kasuga Jun-ichi, Ohgane Kenji, Nishio Yoshino, Morikawa Kosuke, Hashimoto Yuichi, Miyachi Hiroyuki
  Bioorganic & medicinal chemistry 20(11) 3460-3464 2012年6月
• Structural Development Study of a Novel Pharmacological Chaperone for Folding-defective Rhodopsin Mutants Responsible for Retinitis Pigmentosa
  Kenji Ohgane, Kosuke Dodo, Yuichi Hashimoto
  YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN 131(3) 325-334 2011年3月
• Retinobenzaldehydes as proper-trafficking inducers of folding-defective P23H rhodopsin mutant responsible for Retinitis Pigmentosa
  Kenji Ohgane, Kosuke Dodo, Yuichi Hashimoto
  BIOORGANIC & MEDICINAL CHEMISTRY 18(19) 7022-7028 2010年10月
• Peroxisome proliferator-activated receptor (PPAR) agonists with 3,4-dihydro-2H-benzo[e][1,3]oxazine and 2,3,4,5-tetrahydrobenzo[f][1,4]oxazepine skeletons: Effects of cyclization of linker moiety on PPAR-agonistic activity
  Kenji Ohgane, Jyun-ichi Kasuga, Takuji Ohyama, Yuko Hirakawa, Kosuke Morikawa, Makoto Makishima, Yuichi Hashimoto, Hiroyuki Miyachi
  HETEROCYCLES 75(9) 2187-2192 2008年9月

書籍・一般誌・学会誌 | Books

2021~

• 生体分子と疾患 : ヘルスサイエンスの切り札としての化学 (日本化学会編), 分担執筆 (大金賢司, 橋本祐一), Part II 第5章「変異タンパク質と遺伝性フォールディング異常症, 化学同人, ISBN:9784759813999
• コレステロール生合成の新たな制御ポイント―スクアレンモノオキシゲナーゼの基質によるアロステリックな安定化―, 大金 賢司, 吉岡 広大, 生化学 93 147-151 2021年2月

~2020

• 膜タンパク質工学ハンドブック (監修: 津本浩平、浜窪隆雄), 分担執筆 (大金賢司), 第2編-第2章-第2節「コレステロール輸送体NPC1の機能・構造・医薬標的としての可能性」, エヌ・ティー・エス, ISBN:9784860435370, 2020年
• タキソール誘導体の新たな有用性:ほ乳類細胞における半数体細胞の維持, 大金 賢司, ファルマシア 56(4) 345-345, 2020年
• 特集: 標的蛋白質の構造を安定化するシャペロン薬 (取材協力・インタビュー), 日経バイオテク 2019.4.22 4-8 2019年4月
• 神経変性疾患原因タンパク質のケミカルノックダウン, 石川稔, 友重秀介, 野村さやか, 山下博子, 大金 賢司, MEDCHEM NEWS 28(2) 88-92, 2018年
• タンパク質の折り畳みの異常を直す ファーマコロジカルシャペロン―ニーマンピック病C型治療薬を目指した取組み―, 大金賢司, 唐木文霞, どど孝介, 橋本祐一, 現代化学 (512) 48-54, 2013年11月

特許 | Patents

• アルキン含有分子の濃縮精製方法, 袖岡幹子, 大金 賢司, どど孝介, 淺沼三和子, 特願2016-193807 2016年9月30日
• ニーマンピック病C型予防及び/又は治療剤, 大金 賢司, 袖岡 幹子, 特願2015-242513, 2015年12月11日
• ベンズアルデヒド化合物, 橋本 祐一, 大金 賢司, 特願2009-148965 2009年6月23日