{"id":44,"date":"2022-06-24T14:49:14","date_gmt":"2022-06-24T05:49:14","guid":{"rendered":"https:\/\/www-p.sci.ocha.ac.jp\/tanatanilab-test\/?page_id=44"},"modified":"2022-07-08T17:06:20","modified_gmt":"2022-07-08T08:06:20","slug":"research","status":"publish","type":"page","link":"https:\/\/www-p.sci.ocha.ac.jp\/tanatanilab\/research\/","title":{"rendered":"Research(Japanese)"},"content":{"rendered":"\n<p>\u3000\u69cb\u9020\u6709\u6a5f\u5316\u5b66\u3068\u533b\u85ac\u5316\u5b66\u306e\u4e21\u8005\u306b\u643a\u308f\u308b\u7814\u7a76\u5ba4\u3067\u3059\u3002\u4e00\u898b\u3001\u5225\u306e\u5206\u91ce\u306b\u898b\u3048\u308b2\u3064\u306e\u7814\u7a76\u5206\u91ce\u3067\u3059\u304c\u3001\u5206\u5b50\u306e\u7acb\u4f53\u69cb\u9020\u3001\u7279\u6027\u3092\u8a73\u7d30\u306b\u89e3\u6790\u3057\u3001\u305d\u306e\u77e5\u898b\u3092\u3082\u3068\u306b\u3001\u65b0\u898f\u306a\u751f\u7406\u6d3b\u6027\u7269\u8cea\u306e\u8a2d\u8a08\u30fb\u5408\u6210\u3092\u884c\u3046\u3068\u3044\u3046\u70b9\u3067\u30012\u3064\u306e\u7814\u7a76\u30c6\u30fc\u30de\u306f\u6839\u5e95\u3067\u3064\u306a\u304c\u3063\u3066\u3044\u307e\u3059\u3002\u4e3b\u306b\u82b3\u9999\u65cf\u30a2\u30df\u30c9\u3068\u305d\u306e\u95a2\u9023\u5316\u5408\u7269\u306b\u7740\u76ee\u3057\u3001\u7814\u7a76\u3092\u884c\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1.<strong>\u30a2\u30df\u30c9\u304a\u3088\u3073\u95a2\u9023\u5b98\u80fd\u57fa\u306e\u7acb\u4f53\u7279\u6027\u3092\u6d3b\u304b\u3057\u305f\u30e6\u30cb\u30fc\u30af\u306a\u82b3\u9999\u65cf\u5206\u5b50\u69cb\u7bc9<\/strong><\/h2>\n\n\n\n<p>\u3000\u5206\u5b50\u3092\u69cb\u6210\u3059\u308b\u69d8\u3005\u306a\u5b98\u80fd\u57fa\u3001\u90e8\u5206\u69cb\u9020\u306e\u4e2d\u3067\u3082\u3001\u30a2\u30df\u30c9\u7d50\u5408\u306f\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u57fa\u672c\u9aa8\u683c\u3067\u3082\u3042\u308a\u3001\u307e\u305f\u591a\u304f\u306e\u751f\u7406\u6d3b\u6027\u7269\u8cea\u3001\u5206\u5b50\u96c6\u5408\u4f53\u7b49\u306e\u9375\u69cb\u9020\u3068\u3057\u3066\u91cd\u8981\u306a\u6a5f\u80fd\u3092\u679c\u305f\u3057\u3066\u3044\u307e\u3059\u3002\u4e00\u822c\u306b\u3001\u30a2\u30df\u30c9\u7d50\u5408\u53ca\u3073\u985e\u7e01\u5b98\u80fd\u57fa\u3067\u3042\u308b\u30a6\u30ec\u30a2\u3084\u30b0\u30a2\u30cb\u30b8\u30f3\u306f\u3001\u6c34\u7d20\u7d50\u5408\u90e8\u4f4d\u306b\u5bcc\u3093\u3060\u30b0\u30eb\u30fc\u30d7\u3068\u3057\u3066\u3001\u5206\u5b50\u5185\u3082\u3057\u304f\u306f\u5206\u5b50\u9593\u306e\u96fb\u5b50\u7684\u76f8\u4e92\u4f5c\u7528\u3092\u610f\u56f3\u3057\u3066\u5206\u5b50\u69cb\u7bc9\u306b\u7528\u3044\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u4e00\u65b9\u3001\u3053\u308c\u3089\u90e8\u5206\u4e8c\u91cd\u7d50\u5408\u6027\u3092\u6301\u3064\u5b98\u80fd\u57fa\u306e\u7acb\u4f53\u6319\u52d5\u304c\u5206\u5b50\u306e\u4e09\u6b21\u5143\u69cb\u9020\u3084\u7269\u6027\u306b\u95a2\u308f\u308b\u3053\u3068\u3082\u591a\u3005\u307f\u3089\u308c\u307e\u3059\u3002\u672c\u7814\u7a76\u5ba4\u3067\u306f\u3001\u82b3\u9999\u65cf\u30a2\u30df\u30c9\u985e\u304c\u300c<em>N<\/em>-\u30e1\u30c1\u30eb\u5316\u3055\u308c\u308b\u3068\u30b7\u30b9\u578b\u69cb\u9020\u3092\u512a\u5148\u3059\u308b\u300d\u3053\u3068\u306b\u7740\u76ee\u3057\u3001\u305d\u306e\u4e00\u822c\u6027\u3092\u793a\u3057\u3066\u304d\u307e\u3057\u305f(\u56f31)<sup>1)<\/sup>\u3002\u3053\u306e\u7acb\u4f53\u7279\u6027\u306f\u4e00\u898b\u5358\u7d14\u3067\u306f\u3042\u308a\u307e\u3059\u304c\u3001\u3053\u306e\u6027\u8cea\u3092\u7528\u3044\u3066\u3001\u4f8b\u3048\u3070\u3001\u82b3\u9999\u65cf\u591a\u5c64\u69cb\u9020\u3084\u3089\u305b\u3093\u69cb\u9020\u3068\u3044\u3063\u305f\u30e6\u30cb\u30fc\u30af\u306a\u7acb\u4f53\u69cb\u9020\u3084\u52d5\u7684\u6319\u52d5\u3092\u6709\u3059\u308b\u82b3\u9999\u65cf\u5206\u5b50\u306e\u69cb\u7bc9\u304c\u53ef\u80fd\u3067\u3042\u308a\u3001\u3055\u3089\u306b\u89e6\u5a92\u3084\u6db2\u6676\u306a\u3069\u306e\u6a5f\u80fd\u6027\u5206\u5b50\u3078\u306e\u5fdc\u7528\u3082\u9032\u3081\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" src=\"https:\/\/www-p.sci.ocha.ac.jp\/tanatanilab-test\/wp-content\/uploads\/sites\/44\/2022\/06\/5621deba8a18b839c7a4321764bb05e8-1024x709.png\" alt=\"\" class=\"wp-image-48\"\/><figcaption>\u56f31.\u82b3\u9999\u5c5e\u30a2\u30df\u30c9\u304a\u3088\u3073\u95a2\u9023\u5b98\u80fd\u57fa\u306eN-\u30e1\u30c1\u30eb\u5316\u306b\u3088\u308bcis\u578b\u512a\u5148\u6027<br>1)&nbsp;&nbsp;&nbsp;&nbsp; Tanatani, A. et al.&nbsp; <em>J. Synth. Org. Chem., Jpn<\/em> <strong>2000<\/strong>, <em>58<\/em>, 556-567.<\/figcaption><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\">1)<strong>\u82b3\u9999\u65cf\u591a\u5c64\u69cb\u9020\u3068\u52d5\u7684\u3089\u305b\u3093\u5206\u5b50\u306e\u69cb\u7bc9<\/strong><\/h3>\n\n\n\n<p>\u3000\u4e0a\u8ff0\u306e\u82b3\u9999\u65cf\u30a6\u30ec\u30a2\u3084\u30b0\u30a2\u30cb\u30b8\u30f3\u306e\u30b7\u30b9\u578b\u69cb\u9020\u3067\u306f\u30012\u3064\u306e\u82b3\u9999\u74b0\u304c\u5411\u304d\u5408\u3063\u305f\u69cb\u9020\u3092\u3068\u308a\u307e\u3059\u3002\u3055\u3089\u306b\u8907\u6570\u306e\u82b3\u9999\u74b0\u3092\u8907\u6570\u306e\u30b7\u30b9\u578b\u30a6\u30ec\u30a2\u3084\u30b0\u30a2\u30cb\u30b8\u30ce\u57fa\u3067\u9023\u7d50\u3059\u308b\u3068\u82b3\u9999\u5c5e\u591a\u5c64\u69cb\u9020\u304c\u69cb\u7bc9\u3067\u304d\u307e\u3059(\u56f32)<sup>2)<\/sup>\u3002\u30ea\u30f3\u30ab\u30fc\u304c\u30b0\u30a2\u30cb\u30b8\u30ce\u57fa\u306e\u5834\u5408\u306f\u3001\u5206\u5b50\u304c\u6c34\u6eb6\u6027\u3068\u306a\u308a\u3001\u8208\u5473\u6df1\u3044\u3053\u3068\u306b\u3001\u591a\u5c64\u30b0\u30a2\u30cb\u30b8\u30f3<strong>5PG<\/strong>\u306f\u4e8c\u672c\u9396DNA\u306e\u30de\u30a4\u30ca\u30fc\u30b0\u30eb\u30fc\u30d6\u306b\u3074\u3063\u305f\u308a\u3068\u306f\u307e\u308a\u8fbc\u3080\u6027\u8cea\u3092\u6301\u3063\u3066\u3044\u307e\u3057\u305f\u3002 \u307e\u305f\u3001\u5316\u5408\u7269<strong>5MU<\/strong>\u306e\u3088\u3046\u306b\u30e1\u30bf\u4f4d\u3067\u9023\u7d50\u3057\u305f\u5c64\u72b6\u5206\u5b50\u306e\u5834\u5408\u306f\u3001\u3059\u3079\u3066\u306e\u8ef8\u4e0d\u6589\u304cR\u307e\u305f\u306fS\u306b\u305d\u308d\u3063\u305f\u3001\u3089\u305b\u3093\u69d8\u69cb\u9020\u3092\u5f62\u6210\u3057\u3066\u3044\u307e\u3059\u3002 \u3053\u306e\u3089\u305b\u3093\u69d8\u69cb\u9020\u306f\u6eb6\u6db2\u4e2d\u3067\u306f\u53f3\u5dfb\u304d\u3068\u5de6\u5dfb\u304d\u306e\u5206\u5b50\u9593\u3067\u975e\u5e38\u306b\u901f\u3044\u5e73\u8861\u4e0b\u306b\u3042\u308a\u307e\u3059<sup>3,4)<\/sup>\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"709\" src=\"https:\/\/www-p.sci.ocha.ac.jp\/tanatanilab-test\/wp-content\/uploads\/sites\/44\/2022\/06\/2a831ec055ed4fee4e1d0936ea40500d-1024x709.png\" alt=\"\u56f32.\u82b3\u9999\u5c5e\u591a\u5c64\u69cb\u9020\u306e\u69cb\u7bc9\" class=\"wp-image-51\" srcset=\"https:\/\/www-p.sci.ocha.ac.jp\/tanatanilab\/wp-content\/uploads\/sites\/44\/2022\/06\/2a831ec055ed4fee4e1d0936ea40500d-1024x709.png 1024w, https:\/\/www-p.sci.ocha.ac.jp\/tanatanilab\/wp-content\/uploads\/sites\/44\/2022\/06\/2a831ec055ed4fee4e1d0936ea40500d-300x208.png 300w, https:\/\/www-p.sci.ocha.ac.jp\/tanatanilab\/wp-content\/uploads\/sites\/44\/2022\/06\/2a831ec055ed4fee4e1d0936ea40500d-768x532.png 768w, https:\/\/www-p.sci.ocha.ac.jp\/tanatanilab\/wp-content\/uploads\/sites\/44\/2022\/06\/2a831ec055ed4fee4e1d0936ea40500d-24x17.png 24w, https:\/\/www-p.sci.ocha.ac.jp\/tanatanilab\/wp-content\/uploads\/sites\/44\/2022\/06\/2a831ec055ed4fee4e1d0936ea40500d-36x25.png 36w, https:\/\/www-p.sci.ocha.ac.jp\/tanatanilab\/wp-content\/uploads\/sites\/44\/2022\/06\/2a831ec055ed4fee4e1d0936ea40500d-48x33.png 48w, https:\/\/www-p.sci.ocha.ac.jp\/tanatanilab\/wp-content\/uploads\/sites\/44\/2022\/06\/2a831ec055ed4fee4e1d0936ea40500d.png 1040w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><figcaption>\u56f32.\u82b3\u9999\u5c5e\u591a\u5c64\u69cb\u9020\u306e\u69cb\u7bc9<br>2) Tanatani, A. et al.&nbsp; <em>J. Am. Chem. Soc. <\/em><strong>1998<\/strong>, <em>120<\/em>, 6433-6442.<br>3) Kudo, M. et al. <em>J. Org. Chem.<\/em> <strong>2009<\/strong>, <em>74<\/em>, 8154-8163.\u3000\u3000\u3000\u3000\u3000<br>4) Kudo, M.; Tanatani, A. <em>New J. Chem.<\/em> <strong>2015<\/strong>, <em>39<\/em>, 3190-3196.\u3000<\/figcaption><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\">2)\u69d8\u3005\u306a\u82b3\u9999\u74b0\u3092\u6709\u3059\u308b\u30aa\u30ea\u30b4\u30a2\u30df\u30c9\u30d5\u30a9\u30eb\u30c0\u30de\u30fc\u306e\u69cb\u7bc9<\/h3>\n\n\n\n<p>\u3000\u30b7\u30b9\u578b\u69cb\u9020\u3092\u3068\u308b<em>N<\/em>-\u30e1\u30c1\u30eb\u30d9\u30f3\u30ba\u30a2\u30cb\u30ea\u30c9\u3092\u30e2\u30ce\u30de\u30fc\u5358\u4f4d\u3068\u3057\u3066\u30aa\u30ea\u30b4\u30de\u30fc\u3084\u30dd\u30ea\u30de\u30fc\u3092\u69cb\u7bc9\u3059\u308b\u3068\u3001\u3089\u305b\u3093\u69cb\u9020\u3092\u3068\u308a\u307e\u3059(\u56f33)<sup>5)<\/sup>\u3002\u30dd\u30ea\u30a2\u30df\u30c9<strong>1<\/strong>\u306f\u30e2\u30ce\u30de\u30fc\u5206\u5b50<strong>2<\/strong>\u304b\u3089\u9023\u9396\u91cd\u7e2e\u5408\u53cd\u5fdc\u3067\u5206\u5b50\u91cf\u5e45\u306e\u72ed\u3044\u30dd\u30ea\u30de\u30fc\u3068\u3057\u3066\u5408\u6210\u3067\u304d\u307e\u3059\u304c\u3001\u7a92\u7d20\u539f\u5b50\u4e0a\u306b\u30ad\u30e9\u30eb\u306a\u5074\u9396\u3092\u6709\u3057\u3066\u304a\u308a\u3001\u4e00\u65b9\u5411\u5dfb\u304d\u306e\u3089\u305b\u3093\u69cb\u9020\u3092\u512a\u5148\u3057\u3066\u53d6\u308a\u307e\u3059\u3002\u3069\u3061\u3089\u306e\u5dfb\u304d\u65b9\u306b\u306a\u3063\u3066\u3044\u308b\u304b\u306fUV\/CD\u30b9\u30da\u30af\u30c8\u30eb\u306e\u5b9f\u9a13\u7684\u304a\u3088\u3073\u8a08\u7b97\u79d1\u5b66\u7684\u89e3\u6790\u306b\u3088\u308a\u540c\u5b9a\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"709\" src=\"https:\/\/www-p.sci.ocha.ac.jp\/tanatanilab-test\/wp-content\/uploads\/sites\/44\/2022\/06\/ee3be1d100caf1aa771552d59c2bd436-1024x709.png\" alt=\"\" class=\"wp-image-57\" srcset=\"https:\/\/www-p.sci.ocha.ac.jp\/tanatanilab\/wp-content\/uploads\/sites\/44\/2022\/06\/ee3be1d100caf1aa771552d59c2bd436-1024x709.png 1024w, https:\/\/www-p.sci.ocha.ac.jp\/tanatanilab\/wp-content\/uploads\/sites\/44\/2022\/06\/ee3be1d100caf1aa771552d59c2bd436-300x208.png 300w, https:\/\/www-p.sci.ocha.ac.jp\/tanatanilab\/wp-content\/uploads\/sites\/44\/2022\/06\/ee3be1d100caf1aa771552d59c2bd436-768x532.png 768w, https:\/\/www-p.sci.ocha.ac.jp\/tanatanilab\/wp-content\/uploads\/sites\/44\/2022\/06\/ee3be1d100caf1aa771552d59c2bd436-24x17.png 24w, https:\/\/www-p.sci.ocha.ac.jp\/tanatanilab\/wp-content\/uploads\/sites\/44\/2022\/06\/ee3be1d100caf1aa771552d59c2bd436-36x25.png 36w, https:\/\/www-p.sci.ocha.ac.jp\/tanatanilab\/wp-content\/uploads\/sites\/44\/2022\/06\/ee3be1d100caf1aa771552d59c2bd436-48x33.png 48w, https:\/\/www-p.sci.ocha.ac.jp\/tanatanilab\/wp-content\/uploads\/sites\/44\/2022\/06\/ee3be1d100caf1aa771552d59c2bd436.png 1040w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><figcaption>\u56f33.<em>N<\/em>-\u30a2\u30eb\u30ad\u30eb\u5316\u30dd\u30ea\u30d9\u30f3\u30ba\u30a2\u30df\u30c9\u306e\u52d5\u7684\u3089\u305b\u3093\u69cb\u9020<br>5)Tanatani, A. et al. <em>J. Am. Chem. Soc.<\/em> <strong>2005<\/strong>, <em>127<\/em>, 8553-8561.<\/figcaption><\/figure>\n\n\n\n<p>\u3000\u3053\u306e\u3089\u305b\u3093\u69cb\u9020\u3092\u3068\u308b\u30aa\u30ea\u30b4\u30a2\u30df\u30c9\u306f\u3001\u30d9\u30f3\u30bc\u30f3\u74b0\u4ee5\u5916\u306e\u82b3\u9999\u74b0\u3067\u3082\u540c\u69d8\u306b\u69cb\u7bc9\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u5b9f\u969b\u306b\u4e94\u54e1\u74b0\u8907\u7d20\u82b3\u9999\u74b0\u3067\u3042\u308b<em>N<\/em>-\u30e1\u30c1\u30eb\u30d4\u30ed\u30fc\u30eb\u74b0\u3068\u30d9\u30f3\u30bc\u30f3\u74b0\u3092<em>N<\/em> -\u30a2\u30eb\u30ad\u30eb\u5316\u30a2\u30df\u30c9\u3067\u4ea4\u4e92\u306b\u9023\u7d50\u3055\u305b\u305f\u5316\u5408\u7269<strong>3<\/strong>\u304c\u7d50\u6676\u4e2d\u306b\u304a\u3044\u3066\u3089\u305b\u3093\u306e\u90e8\u5206\u69cb\u9020\u306e\u5f62\u72b6\u3092\u3068\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f(\u56f34)<sup>6)<\/sup>\u3002\u672c\u5316\u5408\u7269\u306f\u3001\u30a2\u30df\u30c9\u7d50\u5408\u306e\u7a92\u7d20\u539f\u5b50\u4e0a\u306b\u5149\u5b66\u6d3b\u6027\u306a\u5074\u9396\u3092\u6301\u3064\u3053\u3068\u3067\u3001CD\u30b9\u30da\u30af\u30c8\u30eb\u304c\u6e29\u5ea6\u4f9d\u5b58\u6027\u3001\u9396\u9577\u4f9d\u5b58\u6027\u3092\u793a\u3057\u3001\u52d5\u7684\u306a\u30d5\u30a9\u30fc\u30eb\u30c7\u30a3\u30f3\u30b0\u69cb\u9020\u3092\u3068\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" src=\"https:\/\/www-p.sci.ocha.ac.jp\/tanatanilab-test\/wp-content\/uploads\/sites\/44\/2022\/06\/5f63f49b6b7d98988e1002a4a4f2d6d5-1024x709.png\" alt=\"\" class=\"wp-image-59\"\/><figcaption>\u56f34.\u52d5\u7684\u3089\u305b\u3093\u69cb\u9020\u3092\u6709\u3059\u308b\u30d4\u30ed\u30fc\u30eb\u542b\u6709\u30aa\u30ea\u30b4\u30a2\u30df\u30c9<br>6)Tojo, Y. et al. <em>J. Org. Chem. <\/em><strong>2018<\/strong>, <em>83<\/em>, 4606-4617.<\/figcaption><\/figure>\n\n\n\n<p>\u3000\u3055\u3089\u306b\u4e94\u54e1\u74b0\u8907\u7d20\u82b3\u9999\u74b0\u3092\u30d4\u30ed\u30fc\u30eb\u74b0\u304b\u3089\u30a4\u30df\u30c0\u30be\u30fc\u30eb\u74b0\u3078\u3068\u5c55\u958b\u3057\u305f\u30aa\u30ea\u30b4\u30de\u30fc<strong>4<\/strong>\u3067\u306f\u3001\u30a4\u30df\u30c0\u30be\u30fc\u30eb\u74b0\u3078\u306e\u30d7\u30ed\u30c8\u30f3\u5316\u306b\u3088\u308a\u30b7\u30b9\u578b\u3068\u30c8\u30e9\u30f3\u30b9\u578b\u9593\u306e\u7acb\u4f53\u8ee2\u63db\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001\u305d\u308c\u306b\u4f34\u3063\u3066\u3001\u52d5\u7684\u306b\u69cb\u9020\u3092\u5909\u5316\u3055\u305b\u308b\u30aa\u30ea\u30b4\u30de\u30fc\u3092\u69cb\u7bc9\u3059\u308b\u3053\u3068\u306b\u6210\u529f\u3057\u3066\u3044\u307e\u3059(\u56f35)\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" src=\"https:\/\/www-p.sci.ocha.ac.jp\/tanatanilab-test\/wp-content\/uploads\/sites\/44\/2022\/06\/04f86ea9c104d100d663feb8a9a65769-1024x709.png\" alt=\"\" class=\"wp-image-60\"\/><figcaption>\u56f35.pH\u4f9d\u5b58\u7684\u306b\u7acb\u4f53\u69cb\u9020\u304c\u8ee2\u63db\u3059\u308b\u30a4\u30df\u30c0\u30be\u30fc\u30eb\u542b\u6709\u30aa\u30ea\u30b4\u30a2\u30df\u30c9<\/figcaption><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\">3)\u3089\u305b\u3093\u72b6\u5c64\u72b6\u30a6\u30ec\u30a2\u5206\u5b50\u306e\u30ad\u30e9\u30ea\u30c6\u30a3\u30fc\u3092\u5229\u7528\u3057\u305f\u4e0d\u6589\u6709\u6a5f\u5206\u5b50\u89e6\u5a92\u3078\u306e\u5c55\u958b<\/h3>\n\n\n\n<p>\u3000\u4e0a\u8a18\u3067\u7d39\u4ecb\u3057\u305f\u30b7\u30b9\u578b\u82b3\u9999\u65cf\u30a6\u30ec\u30a2\u306f\u52d5\u7684\u3089\u305b\u3093\u5206\u5b50\u3068\u3057\u3066\u306e\u6027\u8cea\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u30ad\u30e9\u30ea\u30c6\u30a3\u30fc\u306e\u7279\u6027\u3092\u5229\u7528\u3057\u3066\u3001\u4e0d\u6589\u6709\u6a5f\u5206\u5b50\u89e6\u5a92\u306e\u69cb\u7bc9\u3092\u691c\u8a0e\u3057\u3066\u3044\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001\u5149\u5b66\u6d3b\u6027\u5074\u9396\u3092\u5c0e\u5165\u3057\u305f\u30a6\u30ec\u30a2\u5206\u5b50<strong>5<\/strong>\u304c\u4e0d\u6589\u30a2\u30b6\u30d8\u30f3\u30ea\u30fc\u53cd\u5fdc\u306e\u89e6\u5a92\u3068\u3057\u3066\u6a5f\u80fd\u3059\u308b\u3053\u3068\u3092\u307f\u3044\u3060\u3057\u307e\u3057\u305f(\u56f36)\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"330\" src=\"https:\/\/www-p.sci.ocha.ac.jp\/tanatanilab-test\/wp-content\/uploads\/sites\/44\/2022\/06\/63ead695680eb0c485fa3f134844052f-e1657266926101-1024x330.png\" alt=\"\" class=\"wp-image-61\" srcset=\"https:\/\/www-p.sci.ocha.ac.jp\/tanatanilab\/wp-content\/uploads\/sites\/44\/2022\/06\/63ead695680eb0c485fa3f134844052f-e1657266926101-1024x330.png 1024w, https:\/\/www-p.sci.ocha.ac.jp\/tanatanilab\/wp-content\/uploads\/sites\/44\/2022\/06\/63ead695680eb0c485fa3f134844052f-e1657266926101-300x97.png 300w, https:\/\/www-p.sci.ocha.ac.jp\/tanatanilab\/wp-content\/uploads\/sites\/44\/2022\/06\/63ead695680eb0c485fa3f134844052f-e1657266926101-768x248.png 768w, https:\/\/www-p.sci.ocha.ac.jp\/tanatanilab\/wp-content\/uploads\/sites\/44\/2022\/06\/63ead695680eb0c485fa3f134844052f-e1657266926101-24x8.png 24w, https:\/\/www-p.sci.ocha.ac.jp\/tanatanilab\/wp-content\/uploads\/sites\/44\/2022\/06\/63ead695680eb0c485fa3f134844052f-e1657266926101-36x12.png 36w, https:\/\/www-p.sci.ocha.ac.jp\/tanatanilab\/wp-content\/uploads\/sites\/44\/2022\/06\/63ead695680eb0c485fa3f134844052f-e1657266926101-48x15.png 48w, https:\/\/www-p.sci.ocha.ac.jp\/tanatanilab\/wp-content\/uploads\/sites\/44\/2022\/06\/63ead695680eb0c485fa3f134844052f-e1657266926101.png 1039w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><figcaption>\u56f36.Cis\u578b\u30a6\u30ec\u30a2\u69cb\u9020\u3092\u57fa\u76e4\u3068\u3057\u305f\u4e0d\u6589\u6709\u6a5f\u89e6\u5a92\u306e\u5275\u88fd<\/figcaption><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\">4)\u30b9\u30af\u30a2\u30eb\u30a2\u30df\u30c9\u306e\u7279\u5fb4\u3092\u6d3b\u304b\u3057\u305f\u65b0\u305f\u306a\u5206\u5b50\u69cb\u7bc9\u3078\u306e\u5c55\u958b<\/h3>\n\n\n\n<p>\u3000\u30b9\u30af\u30a2\u30eb\u30a2\u30df\u30c9\u306f\u56db\u54e1\u74b0\u69cb\u9020\u3092\u6301\u3064\u30b9\u30af\u30a2\u30ea\u30f3\u9178\u3068\u30a2\u30df\u30f3\u3092\u7e2e\u5408\u3055\u305b\u305f\u5316\u5408\u7269\u3067\u3059\u304c\u3001C-N\u7d50\u5408\u304c\u90e8\u5206\u4e8c\u91cd\u7d50\u5408\u6027\u3092\u6301\u3061\u3001\u30b7\u30b9\u578b\u2015\u30c8\u30e9\u30f3\u30b9\u578b\u7570\u6027\u4f53\u3092\u751f\u3058\u308b\u306a\u3069\u3001\u7acb\u4f53\u7684\u306a\u6027\u8cea\u304c\u30a2\u30df\u30c9\u3084\u30a6\u30ec\u30a2\u3068\u985e\u4f3c\u3057\u3066\u3044\u307e\u3059\u3002\u533b\u85ac\u5316\u5b66\u5206\u91ce\u3067\u306f\u30b9\u30af\u30a2\u30eb\u30a2\u30df\u30c9\u306f\u30a6\u30ec\u30a2\u3084\u30b7\u30a2\u30ce\u30b0\u30a2\u30cb\u30b8\u30f3\u306e\u751f\u7269\u5b66\u7684\u7b49\u4fa1\u6027\u57fa\u3068\u3057\u3066\u3082\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u672c\u7814\u7a76\u5ba4\u3067\u306f\u3001\u82b3\u9999\u5c5e\u30a2\u30df\u30c9\u3084\u30a6\u30ec\u30a2\u306e\u7814\u7a76\u306e\u5c55\u958b\u3068\u3057\u3066\u3001\u30b9\u30af\u30a2\u30eb\u30a2\u30df\u30c9\u3092\u9375\u69cb\u9020\u3068\u3057\u305f\u5206\u5b50\u69cb\u7bc9\u3092\u884c\u3063\u3066\u304a\u308a\u3001\u7d50\u6676\u4e2d\u304a\u3088\u3073\u6eb6\u6db2\u4e2d\u3067\u3089\u305b\u3093(\u56f37\u3001\u5316\u5408\u7269<strong>6a<\/strong>\u7b49)<sup>7)<\/sup>\u3084\u82b3\u9999\u65cf\u5c64\u72b6\u69cb\u9020\u3092\u5f62\u6210\u3059\u308b\u5206\u5b50(\u56f37\u3001\u5316\u5408\u7269<strong>6b,c<\/strong>\u7b49)<sup>8)<\/sup>\u3084\u3001\u5916\u90e8\u74b0\u5883\u306e\u5909\u5316\u306b\u5fdc\u7b54\u3057\u3066\u7acb\u4f53\u69cb\u9020\u3092\u5909\u5316\u3055\u305b\u308b\u5206\u5b50\u30b9\u30a4\u30c3\u30c1\u306e\u69cb\u7bc9\u3001\u6db2\u6676\u5206\u5b50(\u56f38\u3001\u5316\u5408\u7269<strong>7<\/strong>\u7b49)<sup>9)<\/sup>\u3078\u306e\u5c55\u958b\u306a\u3069\u3092\u884c\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"709\" src=\"https:\/\/www-p.sci.ocha.ac.jp\/tanatanilab-test\/wp-content\/uploads\/sites\/44\/2022\/06\/0ae7c62e50dc705df75843b104ce66cd-1024x709.png\" alt=\"\" class=\"wp-image-63\" srcset=\"https:\/\/www-p.sci.ocha.ac.jp\/tanatanilab\/wp-content\/uploads\/sites\/44\/2022\/06\/0ae7c62e50dc705df75843b104ce66cd-1024x709.png 1024w, https:\/\/www-p.sci.ocha.ac.jp\/tanatanilab\/wp-content\/uploads\/sites\/44\/2022\/06\/0ae7c62e50dc705df75843b104ce66cd-300x208.png 300w, https:\/\/www-p.sci.ocha.ac.jp\/tanatanilab\/wp-content\/uploads\/sites\/44\/2022\/06\/0ae7c62e50dc705df75843b104ce66cd-768x532.png 768w, https:\/\/www-p.sci.ocha.ac.jp\/tanatanilab\/wp-content\/uploads\/sites\/44\/2022\/06\/0ae7c62e50dc705df75843b104ce66cd-24x17.png 24w, https:\/\/www-p.sci.ocha.ac.jp\/tanatanilab\/wp-content\/uploads\/sites\/44\/2022\/06\/0ae7c62e50dc705df75843b104ce66cd-36x25.png 36w, https:\/\/www-p.sci.ocha.ac.jp\/tanatanilab\/wp-content\/uploads\/sites\/44\/2022\/06\/0ae7c62e50dc705df75843b104ce66cd-48x33.png 48w, https:\/\/www-p.sci.ocha.ac.jp\/tanatanilab\/wp-content\/uploads\/sites\/44\/2022\/06\/0ae7c62e50dc705df75843b104ce66cd.png 1040w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><figcaption>\u56f37.\u30b9\u30af\u30a2\u30eb\u30a2\u30df\u30c9\u3092\u9375\u69cb\u9020\u3068\u3057\u305f\u5206\u5b50\u69cb\u7bc9\u306e\u4f8b<br>7) Kanda, M. et al. <em>Tetrahedron. <strong>2019<\/strong>, 75, 2771-2777.<\/em><br>8) Arimura, M. et al. <em>Chem. Plus Chem.<\/em> <strong>2021<\/strong>, <em>86, <\/em>198-205<em>.<\/em><\/figcaption><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"709\" src=\"https:\/\/www-p.sci.ocha.ac.jp\/tanatanilab-test\/wp-content\/uploads\/sites\/44\/2022\/06\/2839ab849d9b2c81bd86f4778e9767e3-1024x709.png\" alt=\"\" class=\"wp-image-64\" srcset=\"https:\/\/www-p.sci.ocha.ac.jp\/tanatanilab\/wp-content\/uploads\/sites\/44\/2022\/06\/2839ab849d9b2c81bd86f4778e9767e3-1024x709.png 1024w, https:\/\/www-p.sci.ocha.ac.jp\/tanatanilab\/wp-content\/uploads\/sites\/44\/2022\/06\/2839ab849d9b2c81bd86f4778e9767e3-300x208.png 300w, https:\/\/www-p.sci.ocha.ac.jp\/tanatanilab\/wp-content\/uploads\/sites\/44\/2022\/06\/2839ab849d9b2c81bd86f4778e9767e3-768x532.png 768w, https:\/\/www-p.sci.ocha.ac.jp\/tanatanilab\/wp-content\/uploads\/sites\/44\/2022\/06\/2839ab849d9b2c81bd86f4778e9767e3-24x17.png 24w, https:\/\/www-p.sci.ocha.ac.jp\/tanatanilab\/wp-content\/uploads\/sites\/44\/2022\/06\/2839ab849d9b2c81bd86f4778e9767e3-36x25.png 36w, https:\/\/www-p.sci.ocha.ac.jp\/tanatanilab\/wp-content\/uploads\/sites\/44\/2022\/06\/2839ab849d9b2c81bd86f4778e9767e3-48x33.png 48w, https:\/\/www-p.sci.ocha.ac.jp\/tanatanilab\/wp-content\/uploads\/sites\/44\/2022\/06\/2839ab849d9b2c81bd86f4778e9767e3.png 1040w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><figcaption>\u56f38.\u30b9\u30af\u30a2\u30eb\u30a2\u30df\u30c9\u3092\u9375\u69cb\u9020\u3068\u3057\u305f\u6db2\u6676\u5206\u5b50<br>9)Park, S. et al. <em>Chem. Lett. <strong>2018<\/strong>, 47, 601-604<\/em><\/figcaption><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">2.<strong>\u6838\u5185\u53d7\u5bb9\u4f53\u3092\u5206\u5b50\u6a19\u7684\u3068\u3057\u305f\u533b\u85ac\u5316\u5b66\u7814\u7a76<\/strong><\/h2>\n\n\n\n<p>\u3000\u6838\u5185\u53d7\u5bb9\u4f53\u306f\u3001\u30b9\u30c6\u30ed\u30a4\u30c9\u30db\u30eb\u30e2\u30f3\u3084\u8102\u6eb6\u6027\u30d3\u30bf\u30df\u30f3\u7b49\u306e\u8102\u6eb6\u6027\u4f4e\u5206\u5b50\u5316\u5408\u7269\u304c\u7d50\u5408\u3057\u3066\u521d\u3081\u3066\u7279\u7570\u7684\u907a\u4f1d\u5b50\u767a\u73fe\u306e\u5236\u5fa1\u3092\u884c\u3046\u30ea\u30ac\u30f3\u30c9\u4f9d\u5b58\u7684\u8ee2\u5199\u56e0\u5b50\u3067\u3042\u308a\u3001\u5206\u5316\u3001\u767a\u751f\u3001\u4ee3\u8b1d\u306a\u3069\u306e\u91cd\u8981\u306a\u751f\u547d\u73fe\u8c61\u3092\u53b3\u5bc6\u306b\u8abf\u6574\u3057\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u8fd1\u5e74\u3001\u6838\u5185\u53d7\u5bb9\u4f53\u304c\u764c\u3001\u9aa8\u7c97\u9b06\u75c7\u3001\u7cd6\u5c3f\u75c5\u3001\u52d5\u8108\u786c\u5316\u306a\u3069\u69d8\u3005\u306a\u75be\u60a3\u306e\u767a\u75c7\u3068\u6cbb\u7642\u306b\u95a2\u308f\u3063\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3001\u85ac\u5264\u958b\u767a\u306b\u304a\u3051\u308b\u91cd\u8981\u306a\u5206\u5b50\u6a19\u7684\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u672c\u7814\u7a76\u5ba4\u3067\u306f\u3001\u30a2\u30df\u30c9\u304a\u3088\u3073\u95a2\u9023\u5316\u5408\u7269\u3067\u57f9\u3063\u305f\u69cb\u9020\u7279\u6027\u3082\u6d3b\u304b\u3057\u306a\u304c\u3089\u3001\u65b0\u305f\u306a\u6838\u5185\u53d7\u5bb9\u4f53\u30ea\u30ac\u30f3\u30c9\u306e\u5206\u5b50\u8a2d\u8a08\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">1)\u30a2\u30f3\u30c9\u30ed\u30b2\u30f3\u53d7\u5bb9\u4f53(AR)\u304a\u3088\u3073\u30d7\u30ed\u30b2\u30b9\u30c6\u30ed\u30f3\u53d7\u5bb9\u4f53(PR)\u30a2\u30f3\u30bf\u30b4\u30cb\u30b9\u30c8\u306e\u5275\u88fd<\/h3>\n\n\n\n<p>\u3000\u79c1\u305f\u3061\u306f\u3001\u5f93\u6765\u306e\u30ea\u30ac\u30f3\u30c9\u69cb\u9020\u3068\u306f\u9aa8\u683c\u306e\u7570\u306a\u308b\u30b9\u30c6\u30ed\u30a4\u30c9\u30db\u30eb\u30e2\u30f3\u53d7\u5bb9\u4f53\u30ea\u30ac\u30f3\u30c9\u3092\u5275\u88fd\u3057\u3066\u304d\u307e\u3057\u305f\u3002PR\u30ea\u30ac\u30f3\u30c9\u3068\u3057\u3066\u3001\u86cd\u5149\u30bb\u30f3\u30b5\u30fc\u304b\u3089\u30d2\u30f3\u30c8\u3092\u5f97\u3066\u3001\u30af\u30de\u30ea\u30f3\u74b0\u306b\u7740\u76ee\u3057\u3001\u5206\u5b50\u8a2d\u8a08\u3092\u884c\u3044\u3001\u305d\u306e\u4e2d\u304b\u3089\u30d7\u30ed\u30b2\u30b9\u30c6\u30ed\u30f3\u53d7\u5bb9\u4f53(PR)\u30a2\u30f3\u30bf\u30b4\u30cb\u30b9\u30c8<strong>8<\/strong>(\u56f39)\u3092\u898b\u3044\u3060\u3057\u307e\u3057\u305f<sup>10)<\/sup>\u3002\u672c\u5316\u5408\u7269\u3092\u3082\u3068\u306b\u3001\u7814\u7a76\u5ba4\u306e\u82b3\u9999\u65cf\u30a2\u30df\u30c9\u7814\u7a76\u3067\u5f97\u305f\u30b7\u30b9\u578b\u30a2\u30df\u30c9\u69cb\u9020\u306e\u7acb\u4f53\u7279\u6027\u3092\u7d44\u307f\u5408\u308f\u305b\u3066\u5206\u5b50\u8a2d\u8a08\u3057\u305f\u7d50\u679c\u3001\u30af\u30de\u30ea\u30f3\u74b0\u3092\u30d5\u30a1\u30fc\u30de\u30b3\u30d5\u30a9\u30a2\u3068\u3059\u308b\u30a2\u30f3\u30c9\u30ed\u30b2\u30f3\u53d7\u5bb9\u4f53(AR)\u30a2\u30f3\u30bf\u30b4\u30cb\u30b9\u30c8<strong>9<\/strong>\u3092\u898b\u3044\u3060\u3057\u307e\u3057\u305f<sup>11)<\/sup>\u3002\u66f4\u306b\u3001\u30a2\u30df\u30c9\u3092\u30b9\u30eb\u30d5\u30a9\u30f3\u30a2\u30df\u30c9\u306b\u4ee3\u66ff\u3059\u308b\u3053\u3068\u3067\u3001\u518d\u3073\u30d7\u30ed\u30b2\u30b9\u30c6\u30ed\u30f3\u53d7\u5bb9\u4f53(PR)\u30a2\u30f3\u30bf\u30b4\u30cb\u30b9\u30c8<strong>10<\/strong>\u306b\u30b9\u30a4\u30c3\u30c1\u3059\u308b\u3053\u3068\u3092\u898b\u3044\u3060\u3057\u307e\u3057\u305f\u3002\u6700\u8fd1\u3067\u306f\u3001\u30af\u30de\u30ea\u30f3\u74b0\u304b\u3089\u30ad\u30ce\u30ed\u30f3\u74b0\u3078\u5909\u63db\u3059\u308b\u3053\u3068\u3067\u6d3b\u6027\u5897\u5f37\u304c\u898b\u3089\u308c\u308b\u3053\u3068\u3082\u308f\u304b\u308a\u3001\u975e\u30b9\u30c6\u30ed\u30a4\u30c9\u578b\u30ea\u30ac\u30f3\u30c9\u3068\u3057\u3066\u3001\u72ec\u81ea\u306e\u69cb\u9020\u30e9\u30a4\u30d6\u30e9\u30ea\u30fc\u3092\u69cb\u7bc9\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" src=\"https:\/\/www-p.sci.ocha.ac.jp\/tanatanilab-test\/wp-content\/uploads\/sites\/44\/2022\/06\/7d2a8a5d380f463388d1c8d4512bef57-1024x709.png\" alt=\"\" class=\"wp-image-67\"\/><figcaption>\u56f39.\u30a2\u30df\u30c9\u306e\u7acb\u4f53\u7279\u6027\u306b\u57fa\u3065\u304d\u3001\u6a19\u7684\u53d7\u5bb9\u4f53\u304c\u7570\u306a\u308b\u30af\u30de\u30ea\u30f3\u30fb\u30ad\u30ce\u30ed\u30f3\u8a98\u5c0e\u4f53<br>10)  Sakai, H. et al. <em>J. Med. Chem., <strong>2011<\/strong>, 54, 7055-7065.<\/em><br>11) Koga, H. et al. <em>Int. J. Mol. Sci.<\/em>, <strong>2020<\/strong>, <em>21<\/em>, 5584.<\/figcaption><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\">2)\u80c6\u6c41\u9178\u3092\u30ea\u30fc\u30c9\u3068\u3057\u305f\u9ad8\u6d3b\u6027\u975e\u30bb\u30b3\u30b9\u30c6\u30ed\u30a4\u30c9\u578b\u30d3\u30bf\u30df\u30f3D\u8a98\u5c0e\u4f53\u306e\u5275\u88fd<\/h3>\n\n\n\n<p>\u3000\u30d3\u30bf\u30df\u30f3D\u306f\u3001\u751f\u4f53\u5185\u3067\u4ee3\u8b1d\u3055\u308c\u3066\u6d3b\u6027\u672c\u4f53\u3067\u3042\u308b1a,25(OH)<sub>2<\/sub>D<sub>3<\/sub>\u3068\u306a\u308a\u3001\u30d3\u30bf\u30df\u30f3D\u306e\u6838\u5185\u53d7\u5bb9\u4f53(VDR)\u306b\u7d50\u5408\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u7279\u7570\u7684\u306a\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3092\u5236\u5fa1\u3057\u3066\u3001\u8840\u4e2d\u306e\u30ab\u30eb\u30b7\u30a6\u30e0\u6fc3\u5ea6\u7dad\u6301\u3084\u9aa8\u5f62\u6210\u3001\u514d\u75ab\u6a5f\u80fd\u3001\u7d30\u80de\u306e\u5206\u5316\u30fb\u5897\u6b96\u5236\u5fa1\u306a\u3069\u306e\u91cd\u8981\u306a\u751f\u7406\u4f5c\u7528\u3092\u62c5\u3063\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u307e\u3067\u306b\u3001\u304c\u3093\u3001\u9aa8\u7c97\u9b06\u75c7\u306a\u3069\u306e\u75be\u60a3\u6cbb\u7642\u85ac\u3078\u306e\u5fdc\u7528\u3092\u76ee\u7684\u306b\u591a\u304f\u306e\u30d3\u30bf\u30df\u30f3D\u8a98\u5c0e\u4f53\u304c\u5275\u88fd\u3055\u308c\u3066\u304d\u307e\u3057\u305f\u304c\u3001\u533b\u85ac\u54c1\u306b\u306a\u3063\u305f\u5316\u5408\u7269\u3082\u542b\u3081\u3001\u9ad8\u6d3b\u6027\u306a\u8a98\u5c0e\u4f53\u306f\u3044\u305a\u308c\u3082\u5929\u7136\u578b\u30d3\u30bf\u30df\u30f3D\u3068\u540c\u3058\u30bb\u30b3\u30b9\u30c6\u30ed\u30a4\u30c9\u3068\u3088\u3070\u308c\u308b\u69cb\u9020\u3092\u6301\u3063\u3066\u3044\u307e\u3057\u305f\u3002\u8fd1\u5e74\u3001\u30bb\u30b3\u30b9\u30c6\u30ed\u30a4\u30c9\u69cb\u9020\u3092\u6301\u305f\u306a\u3044\u9ad8\u6d3b\u6027\u30d3\u30bf\u30df\u30f3D\u8a98\u5c0e\u4f53\u304c\u5831\u544a\u3055\u308c\u307e\u3057\u305f\u304c\u3001\u305d\u306e\u6570\u306f\u9650\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>2002\u5e74\u306bVDR\u306e\u7b2c2\u306e\u5185\u56e0\u6027\u30a2\u30b4\u30cb\u30b9\u30c8\u3068\u3057\u3066\u30ea\u30c8\u30b3\u30fc\u30eb\u9178\u304c\u898b\u3044\u3060\u3055\u308c\u307e\u3057\u305f\u304c\u3001\u305d\u306e\u6d3b\u6027\u306f1a,25(OH)<sub>2<\/sub>D<sub>3<\/sub>\u3068\u6bd4\u3079\u308b\u3068\u975e\u5e38\u306b\u5f31\u3044\u3082\u306e\u3067\u3057\u305f\u3002\u79c1\u305f\u3061\u306f\u3001\u30ea\u30c8\u30b3\u30fc\u30eb\u9178\u3068VDR\u306e\u8907\u5408\u4f53\u306e\u7d50\u6676\u69cb\u9020\u3092\u3082\u3068\u306b\u9ad8\u3044\u30d3\u30bf\u30df\u30f3D\u6d3b\u6027\u3092\u6301\u3064\u30ea\u30c8\u30b3\u30fc\u30eb\u3055\u3093\u8a98\u5c0e\u4f53<strong>Dcha-20<\/strong>\u306e\u5275\u88fd\u306b\u6210\u529f\u3057\u307e\u3057\u305f(\u56f310)<sup>12)<\/sup>\u3002\u73fe\u5728\u3001<strong>Dcha-20<\/strong>\u306e\u533b\u85ac\u5fdc\u7528\u3092\u56f3\u308b\u3068\u3068\u3082\u306b\u3001\u3055\u3089\u306a\u308b\u69cb\u9020\u5c55\u958b\u3092\u884c\u3063\u3066\u3044\u307e\u3059<sup>13)<\/sup>\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"709\" src=\"https:\/\/www-p.sci.ocha.ac.jp\/tanatanilab-test\/wp-content\/uploads\/sites\/44\/2022\/06\/40dcbe9d88c96297b642179a653642d8-1024x709.png\" alt=\"\" class=\"wp-image-68\" srcset=\"https:\/\/www-p.sci.ocha.ac.jp\/tanatanilab\/wp-content\/uploads\/sites\/44\/2022\/06\/40dcbe9d88c96297b642179a653642d8-1024x709.png 1024w, https:\/\/www-p.sci.ocha.ac.jp\/tanatanilab\/wp-content\/uploads\/sites\/44\/2022\/06\/40dcbe9d88c96297b642179a653642d8-300x208.png 300w, https:\/\/www-p.sci.ocha.ac.jp\/tanatanilab\/wp-content\/uploads\/sites\/44\/2022\/06\/40dcbe9d88c96297b642179a653642d8-768x532.png 768w, https:\/\/www-p.sci.ocha.ac.jp\/tanatanilab\/wp-content\/uploads\/sites\/44\/2022\/06\/40dcbe9d88c96297b642179a653642d8-24x17.png 24w, https:\/\/www-p.sci.ocha.ac.jp\/tanatanilab\/wp-content\/uploads\/sites\/44\/2022\/06\/40dcbe9d88c96297b642179a653642d8-36x25.png 36w, https:\/\/www-p.sci.ocha.ac.jp\/tanatanilab\/wp-content\/uploads\/sites\/44\/2022\/06\/40dcbe9d88c96297b642179a653642d8-48x33.png 48w, https:\/\/www-p.sci.ocha.ac.jp\/tanatanilab\/wp-content\/uploads\/sites\/44\/2022\/06\/40dcbe9d88c96297b642179a653642d8.png 1040w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><figcaption>\u56f310.\u9ad8\u3044\u30d3\u30bf\u30df\u30f3D\u6d3b\u6027\u3092\u6709\u3059\u308b\u30ea\u30c8\u30b3\u30fc\u30eb\u9178\u8a98\u5c0e\u4f53<strong>Dcha-20<\/strong><br>12)  Sasaki, H. et al. <em>J. Med. Chem. <\/em><strong>2021<\/strong><em>, 64<\/em>, 516-526.<br>13) Yoshihara, A. et al. <em>Biomol. <\/em><strong>2022<\/strong>, <em>12<\/em>, 130.<\/figcaption><\/figure>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u3000\u69cb\u9020\u6709\u6a5f\u5316\u5b66\u3068\u533b\u85ac\u5316\u5b66\u306e\u4e21\u8005\u306b\u643a\u308f\u308b\u7814\u7a76\u5ba4\u3067\u3059\u3002\u4e00\u898b\u3001\u5225\u306e\u5206\u91ce\u306b\u898b\u3048\u308b2\u3064\u306e\u7814\u7a76\u5206\u91ce\u3067\u3059\u304c\u3001\u5206\u5b50\u306e\u7acb\u4f53\u69cb\u9020\u3001\u7279\u6027\u3092\u8a73\u7d30\u306b\u89e3\u6790\u3057\u3001\u305d\u306e\u77e5\u898b\u3092\u3082\u3068\u306b\u3001\u65b0\u898f\u306a\u751f\u7406\u6d3b\u6027\u7269\u8cea\u306e\u8a2d\u8a08\u30fb\u5408\u6210\u3092\u884c\u3046\u3068\u3044\u3046\u70b9\u3067\u30012\u3064\u306e\u7814\u7a76\u30c6\u30fc\u30de\u306f\u6839\u5e95\u3067 &hellip; <a href=\"https:\/\/www-p.sci.ocha.ac.jp\/tanatanilab\/research\/\">\u7d9a\u304d\u3092\u8aad\u3080 <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":43,"featured_media":0,"parent":0,"menu_order":2,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-44","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www-p.sci.ocha.ac.jp\/tanatanilab\/wp-json\/wp\/v2\/pages\/44","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www-p.sci.ocha.ac.jp\/tanatanilab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www-p.sci.ocha.ac.jp\/tanatanilab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www-p.sci.ocha.ac.jp\/tanatanilab\/wp-json\/wp\/v2\/users\/43"}],"replies":[{"embeddable":true,"href":"https:\/\/www-p.sci.ocha.ac.jp\/tanatanilab\/wp-json\/wp\/v2\/comments?post=44"}],"version-history":[{"count":12,"href":"https:\/\/www-p.sci.ocha.ac.jp\/tanatanilab\/wp-json\/wp\/v2\/pages\/44\/revisions"}],"predecessor-version":[{"id":173,"href":"https:\/\/www-p.sci.ocha.ac.jp\/tanatanilab\/wp-json\/wp\/v2\/pages\/44\/revisions\/173"}],"wp:attachment":[{"href":"https:\/\/www-p.sci.ocha.ac.jp\/tanatanilab\/wp-json\/wp\/v2\/media?parent=44"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}