{"id":414,"date":"2024-10-24T13:06:21","date_gmt":"2024-10-24T04:06:21","guid":{"rendered":"https:\/\/www-p.sci.ocha.ac.jp\/ohganelab\/?p=414"},"modified":"2024-10-26T14:55:25","modified_gmt":"2024-10-26T05:55:25","slug":"%e5%a4%a7%e9%87%91%e3%81%8c%e5%85%b1%e8%91%97%e3%81%ae%e8%ab%96%e6%96%87%e3%81%8cjci-insight%e3%81%ab%e6%8e%b2%e8%bc%89%e3%81%95%e3%82%8c%e3%81%be%e3%81%97%e3%81%9f","status":"publish","type":"post","link":"https:\/\/www-p.sci.ocha.ac.jp\/ohganelab\/2024\/10\/24\/%e5%a4%a7%e9%87%91%e3%81%8c%e5%85%b1%e8%91%97%e3%81%ae%e8%ab%96%e6%96%87%e3%81%8cjci-insight%e3%81%ab%e6%8e%b2%e8%bc%89%e3%81%95%e3%82%8c%e3%81%be%e3%81%97%e3%81%9f\/","title":{"rendered":"\u5927\u91d1\u304c\u5171\u8457\u306e\u8ad6\u6587\u304cJCI Insight\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f"},"content":{"rendered":"

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Azaria, R. D.; Correia, A. B.; Schache, K. J.; Zapata, M.; Pathmasiri, K. C.; Mohanty, V.; Nannapaneni, D. T.; Ashfeld, B. L.; Helquist, P.; Wiest, O.; Ohgane, K.<\/span>; Li, Q.; Fredenburg, R. A.; Blagg, B. S. J.; Cologna, S. M.; Schultz, M. L.*; Lieberman, A. P.*
\nMutant Induced Neurons and Humanized Mice Enable Identification of Niemann-Pick C1 Proteostatic Therapies.
\nJCI Insight <\/i>2024<\/b>, 9<\/i> (20), e179525. (\u30aa\u30fc\u30d7\u30f3\u30a2\u30af\u30bb\u30b9) https:\/\/doi.org\/10.1172\/jci.insight.179525.\u00a0<\/a><\/span><\/span><\/p><\/blockquote>\n

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\"\"<\/p><\/blockquote>\n

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\u307e\u305f\u3001\u65b0\u3057\u3044\u30e2\u30c7\u30eb\u30de\u30a6\u30b9\u306b\u3064\u3044\u3066\u3082\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002\u30cb\u30fc\u30de\u30f3\u30d4\u30c3\u30af\u75c5C\u578b\u306e\u30e2\u30c7\u30eb\u30de\u30a6\u30b9\u306f\u3059\u3067\u306b\u5b58\u5728\u3057\u3066\u3044\u307e\u3057\u305f\u304c\u3001\u30de\u30a6\u30b9\u306eNPC1\u3068\u30d2\u30c8\u306eNPC1\u306f\u914d\u5217\u304c\u7570\u306a\u308b\u305f\u3081 (86%\u306f\u540c\u4e00)\u3001\u30d2\u30c8\u3067\u983b\u5ea6\u306e\u9ad8\u3044I1061T\u5909\u7570\u4f53 (1061\u756a\u76ee\u306e\u30a4\u30bd\u30ed\u30a4\u30b7\u30f3\u304c\u30b9\u30ec\u30aa\u30cb\u30f3\u306b\u5909\u308f\u3063\u305f\u5909\u7570\u4f53)\u306b\u304a\u3044\u3066\u3001\u30d2\u30c8NPC1\u3067\u898b\u3089\u308c\u308b\u30d5\u30a9\u30fc\u30eb\u30c7\u30a3\u30f3\u30b0\u7570\u5e38\u304c\u898b\u3089\u308c\u305a\u3001\u85ac\u7406\u5b66\u7684\u30b7\u30e3\u30da\u30ed\u30f3\u7b49\u306e\u8a55\u4fa1\u304c\u3067\u304d\u306a\u3044\u3068\u3044\u3046\u8ab2\u984c\u304c\u3042\u308a\u307e\u3057\u305f\u3002<\/p>\n

\"\"<\/p><\/blockquote>\n

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\"\"<\/p><\/blockquote>\n

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\u5927\u91d1<\/p>\n","protected":false},"excerpt":{"rendered":"

\u5927\u91d1\u304c\u5171\u8457\u306b\u5165\u3063\u305f\u8ad6\u6587\u304c\u3001JCI Insight\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002\u57fa\u672c\u7684\u306b\u306f\u5171\u540c\u7814\u7a76\u8005\u306e\u7814\u7a76\u3067\u3059\u304c\u3001\u5316\u5408\u7269\u9762\u3067\u5bc4\u4e0e\u3057\u3066\u3044\u308b\u7814\u7a76\u3067\u3059\u3002 Azaria, R. D.; Correia, A. B.; Schache, K. … \u7d9a\u304d\u3092\u8aad\u3080 →<\/span><\/a><\/p>\n","protected":false},"author":48,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-414","post","type-post","status-publish","format-standard","hentry","category-ohganelabnews"],"_links":{"self":[{"href":"https:\/\/www-p.sci.ocha.ac.jp\/ohganelab\/wp-json\/wp\/v2\/posts\/414","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www-p.sci.ocha.ac.jp\/ohganelab\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www-p.sci.ocha.ac.jp\/ohganelab\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www-p.sci.ocha.ac.jp\/ohganelab\/wp-json\/wp\/v2\/users\/48"}],"replies":[{"embeddable":true,"href":"https:\/\/www-p.sci.ocha.ac.jp\/ohganelab\/wp-json\/wp\/v2\/comments?post=414"}],"version-history":[{"count":5,"href":"https:\/\/www-p.sci.ocha.ac.jp\/ohganelab\/wp-json\/wp\/v2\/posts\/414\/revisions"}],"predecessor-version":[{"id":424,"href":"https:\/\/www-p.sci.ocha.ac.jp\/ohganelab\/wp-json\/wp\/v2\/posts\/414\/revisions\/424"}],"wp:attachment":[{"href":"https:\/\/www-p.sci.ocha.ac.jp\/ohganelab\/wp-json\/wp\/v2\/media?parent=414"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www-p.sci.ocha.ac.jp\/ohganelab\/wp-json\/wp\/v2\/categories?post=414"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www-p.sci.ocha.ac.jp\/ohganelab\/wp-json\/wp\/v2\/tags?post=414"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}