{"id":287,"date":"2022-12-26T12:18:38","date_gmt":"2022-12-26T03:18:38","guid":{"rendered":"https:\/\/www-p.sci.ocha.ac.jp\/ohganelab\/?p=287"},"modified":"2022-12-28T14:03:52","modified_gmt":"2022-12-28T05:03:52","slug":"%e7%a0%94%e7%a9%b6%e6%88%90%e6%9e%9c%e3%81%8cbioorg-med-chem%e8%aa%8c%e3%81%ab%e6%8e%b2%e8%bc%89%e3%81%95%e3%82%8c%e3%81%be%e3%81%97%e3%81%9f-%e7%90%86%e7%a7%91%e5%a4%a7%e3%83%bb%e6%b2%b3%e6%9d%91","status":"publish","type":"post","link":"https:\/\/www-p.sci.ocha.ac.jp\/ohganelab\/2022\/12\/26\/%e7%a0%94%e7%a9%b6%e6%88%90%e6%9e%9c%e3%81%8cbioorg-med-chem%e8%aa%8c%e3%81%ab%e6%8e%b2%e8%bc%89%e3%81%95%e3%82%8c%e3%81%be%e3%81%97%e3%81%9f-%e7%90%86%e7%a7%91%e5%a4%a7%e3%83%bb%e6%b2%b3%e6%9d%91\/","title":{"rendered":"\u7814\u7a76\u6210\u679c\u304cBioorg Med Chem\u8a8c\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f (\u7406\u79d1\u5927\u30fb\u6cb3\u6751\u304f\u3093)"},"content":{"rendered":"

HMG-CoA\u9084\u5143\u9175\u7d20\u306e\u5206\u89e3\u3092\u8a98\u5c0e\u3059\u308b\u4f4e\u5206\u5b50\u5316\u5408\u7269\u306b\u95a2\u3059\u308b\u7814\u7a76\u6210\u679c\u304cBioorg Med Chem\u8a8c\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002\u6771\u4eac\u7406\u79d1\u5927\u5b66\u7406\u5de5\u5b66\u90e8\u5fdc\u7528\u751f\u7269\u79d1\u5b66\u79d1(\u5009\u6301\u7814\u7a76\u5ba4)\u306e\u4fee\u58eb2\u5e74 \u6cb3\u6751\u5e78\u6c70\u304f\u3093\u306e\u7814\u7a76\u6210\u679c\u3067\u3059\u3002\u3053\u306e\u8ad6\u6587\u306b\u51fa\u3066\u3044\u308b\u5316\u5408\u7269\u3060\u3051\u3067\u3001\u5b66\u90e84\u5e74\u304b\u3089\u4fee\u58eb2\u5e74\u307e\u3067\u306e3\u5e74\u9593\u3067\u5408\u6210\u3057\u305f26\u5316\u5408\u7269 (\u8a0885\u53cd\u5fdc)\u3042\u308a\u307e\u3059\u3002\u6cb3\u6751\u304f\u3093\u306f\u305d\u306e\u307b\u307c\u5168\u3066\u306e\u5316\u5408\u7269\u306e\u5408\u6210\u3068\u57f9\u990a\u7d30\u80de\u3092\u7528\u3044\u305f\u6d3b\u6027\u8a55\u4fa1\u3092\u884c\u306a\u3063\u3066\u304f\u308c\u307e\u3057\u305f\u3002\u304a\u75b2\u308c\u3055\u307e\u3067\u3057\u305f\u3002<\/p>\n

HMG-CoA\u9084\u5143\u9175\u7d20\u306f\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5408\u6210\u7d4c\u8def\u306e\u91cd\u8981\u306a1\u53cd\u5fdc\u3092\u62c5\u3046\u9175\u7d20\u3067\u3001\u30b9\u30bf\u30c1\u30f3\u3068\u7dcf\u79f0\u3055\u308c\u308b\u85ac\u5264\u306f\u305d\u306e\u89e6\u5a92\u6d3b\u6027\u3092\u963b\u5bb3\u3057\u3001\u8840\u4e2d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u4f4e\u4e0b\u4f5c\u7528\u3092\u793a\u3057\u307e\u3059\u3002\u3053\u306e\u7814\u7a76\u3067\u6271\u3063\u3066\u3044\u308b\u5316\u5408\u7269\u306f\u3001\u3053\u306e\u9175\u7d20\u81ea\u4f53\u306e\u91cf\u3092\u6e1b\u3089\u3059(=\u9175\u7d20\u306e\u5206\u89e3\u3092\u8a98\u5c0e\u3059\u308b)\u3068\u3044\u3046\u5909\u308f\u3063\u305f\u4f5c\u7528\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002\u7814\u7a76\u5ba4\u3068\u3057\u3066\u3053\u306e\u3088\u3046\u306a\u5909\u308f\u3063\u305f\u6d3b\u6027\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306a\u3069\u306b\u3082\u8208\u5473\u3092\u6301\u3063\u3066\u3044\u308b\u308f\u3051\u3067\u3059\u304c\u3001\u4eca\u56de\u306e\u7814\u7a76\u3067\u306f\u3053\u306e\u3088\u3046\u306a\u5909\u308f\u3063\u305f\u6d3b\u6027\u3092\u6301\u3064\u3088\u308a\u512a\u308c\u305f\u5316\u5408\u7269\u306e\u63a2\u7d22\u3092\u9032\u3081\u307e\u3057\u305f\u3002<\/p>\n

\u30d4\u30ea\u30b8\u30f3\u74b0(\u3084\u4ed6\u306e\u542b\u7a92\u7d20\u30d8\u30c6\u30ed\u74b0)\u306b\u5bfe\u3057\u3066\u7cfb\u7d71\u7684\u306b\u7f6e\u63db\u57fa\u3092\u5c0e\u5165\u3057\u3066\u69cb\u9020\u6d3b\u6027\u76f8\u95a2\u3092\u8abf\u3079\u308b\u306e\u306f\u306a\u304b\u306a\u304b\u5927\u5909\u3067\u3059\u304c\u3001\u6539\u826f\u578bMinisci\u53cd\u5fdc(\u30e9\u30b8\u30ab\u30eb\u53cd\u5fdc\u306e\u4e00\u7a2e\u3067\u30d8\u30c6\u30ed\u74b0\u306eC-H\u7d50\u5408\u306b\u30a2\u30eb\u30ad\u30eb\u57fa\u3092\u5c0e\u5165\u3067\u304d\u308b\u53cd\u5fdc)\u3092\u3046\u307e\u304f\u6d3b\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u52b9\u7387\u7684\u306b\u8a98\u5c0e\u4f53\u306e\u5408\u6210\u3092\u9032\u3081\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u307e\u305f\u8a98\u5c0e\u4f53\u5408\u6210\u306e\u904e\u7a0b\u3067\u3001(\u30da\u30eb)\u30d5\u30eb\u30aa\u30ed\u30a2\u30eb\u30ad\u30eb\u57fa\u306e\u30d4\u30ea\u30b8\u30f3\u74b0\u3078\u306e\u30e9\u30b8\u30ab\u30eb\u53cd\u5fdc\u306b\u3088\u308b\u5c0e\u5165\u306b\u3064\u3044\u3066\u3001\u304a\u8336\u5927\u5316\u5b66\u79d1\u306e\u77e2\u5cf6\u7814\u30fb\u4f50\u85e4\u5343\u82b1\u5b50\u3055\u3093\u304c\u691c\u8a0e\u3092\u304a\u3053\u306a\u3063\u3066\u304f\u308c\u307e\u3057\u305f\u3002\u3042\u308a\u304c\u3068\u3046\u3054\u3056\u3044\u307e\u3057\u305f\u3002\u7d50\u679c\u7684\u306b\u306f\u3001\u96fb\u5b50\u4e0d\u8db3\u306a\u30d8\u30c6\u30ed\u74b0\u306b\u5bfe\u3057\u3066\u96fb\u5b50\u4e0d\u8db3\u306a\u30da\u30eb\u30d5\u30eb\u30aa\u30ed\u30a2\u30eb\u30ad\u30eb\u30e9\u30b8\u30ab\u30eb\u3092\u76f4\u63a5\u5c0e\u5165\u3059\u308b\u306e\u306f\u7c21\u5358\u3067\u306f\u306a\u304f\u3001\u3053\u306e\u7814\u7a76\u3067\u306f\u30d2\u30c9\u30ed\u30ad\u30b7\u30eb\u57fa\u3092\u5f8c\u304b\u3089\u30d5\u30c3\u7d20\u306b\u7f6e\u63db\u3059\u308b\u3068\u3044\u3046\u5408\u6210\u7d4c\u8def\u3092\u63a1\u7528\u3057\u307e\u3057\u305f\u3002<\/p>\n

\u8ad6\u6587\u306f\u4e0b\u8a18\u30ea\u30f3\u30af\u304b\u3089\u8aad\u3081\u307e\u3059\u306e\u3067\u3001\u305c\u3072\u3054\u89a7\u304f\u3060\u3055\u3044\u3002<\/p>\n

\u5927\u91d1<\/p>\n

———–<\/p>\n

Bioorg Med Chem\u8a8c\u306e\u30da\u30fc\u30b8 (\u6709\u6599 \/ \u6240\u5c5e\u6a5f\u95a2\u306e\u5951\u7d04\u304c\u5fc5\u8981\u3067\u3059): https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0968089622005387<\/a><\/p>\n

Bioorg Med Chem\u8a8cShareLink (2023.2.16\u307e\u3067\u306f\u7121\u6599\u3067\u6700\u7d42\u7248\u306b\u30a2\u30af\u30bb\u30b9\u53ef\u80fd) https:\/\/authors.elsevier.com\/a\/1gKCd3S7Zk1yQB<\/a><\/p>\n

\u30d7\u30ec\u30d7\u30ea\u30f3\u30c8\u7248 (\u7121\u6599\u3067\u898b\u308c\u308b\u8457\u8005\u539f\u7a3f\u3067\u3059): https:\/\/ssrn.com\/abstract=4285357<\/a><\/p>\n

\"\"<\/a>

\u30b0\u30e9\u30d5\u30a3\u30ab\u30eb\u30a2\u30d6\u30b9\u30c8\u30e9\u30af\u30c8 (Kawamura et al., 2022 Bioorg. Med. Chem.)<\/p><\/div>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

HMG-CoA\u9084\u5143\u9175\u7d20\u306e\u5206\u89e3\u3092\u8a98\u5c0e\u3059\u308b\u4f4e\u5206\u5b50\u5316\u5408\u7269\u306b\u95a2\u3059\u308b\u7814\u7a76\u6210\u679c\u304cBioorg Med Chem\u8a8c\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002\u6771\u4eac\u7406\u79d1\u5927\u5b66\u7406\u5de5\u5b66\u90e8\u5fdc\u7528\u751f\u7269\u79d1\u5b66\u79d1(\u5009\u6301\u7814\u7a76\u5ba4)\u306e\u4fee\u58eb2\u5e74 \u6cb3\u6751\u5e78\u6c70\u304f\u3093\u306e\u7814\u7a76\u6210\u679c\u3067\u3059\u3002\u3053\u306e\u8ad6\u6587\u306b\u51fa\u3066 … \u7d9a\u304d\u3092\u8aad\u3080 →<\/span><\/a><\/p>\n","protected":false},"author":48,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-287","post","type-post","status-publish","format-standard","hentry","category-ohganelabnews"],"_links":{"self":[{"href":"https:\/\/www-p.sci.ocha.ac.jp\/ohganelab\/wp-json\/wp\/v2\/posts\/287","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www-p.sci.ocha.ac.jp\/ohganelab\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www-p.sci.ocha.ac.jp\/ohganelab\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www-p.sci.ocha.ac.jp\/ohganelab\/wp-json\/wp\/v2\/users\/48"}],"replies":[{"embeddable":true,"href":"https:\/\/www-p.sci.ocha.ac.jp\/ohganelab\/wp-json\/wp\/v2\/comments?post=287"}],"version-history":[{"count":4,"href":"https:\/\/www-p.sci.ocha.ac.jp\/ohganelab\/wp-json\/wp\/v2\/posts\/287\/revisions"}],"predecessor-version":[{"id":294,"href":"https:\/\/www-p.sci.ocha.ac.jp\/ohganelab\/wp-json\/wp\/v2\/posts\/287\/revisions\/294"}],"wp:attachment":[{"href":"https:\/\/www-p.sci.ocha.ac.jp\/ohganelab\/wp-json\/wp\/v2\/media?parent=287"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www-p.sci.ocha.ac.jp\/ohganelab\/wp-json\/wp\/v2\/categories?post=287"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www-p.sci.ocha.ac.jp\/ohganelab\/wp-json\/wp\/v2\/tags?post=287"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}