{"id":195,"date":"2022-02-18T12:12:46","date_gmt":"2022-02-18T03:12:46","guid":{"rendered":"https:\/\/www-p.sci.ocha.ac.jp\/ohganelab\/?p=195"},"modified":"2022-02-18T12:12:46","modified_gmt":"2022-02-18T03:12:46","slug":"%e7%a0%94%e7%a9%b6%e6%88%90%e6%9e%9c%e3%81%8cacs-med-chem-lett%e8%aa%8c%e3%81%ab%e6%8e%b2%e8%bc%89%e3%81%95%e3%82%8c%e3%81%be%e3%81%97%e3%81%9f-%e5%a4%a7%e9%87%91%e3%81%8c%e5%85%b1%e8%91%97","status":"publish","type":"post","link":"https:\/\/www-p.sci.ocha.ac.jp\/ohganelab\/2022\/02\/18\/%e7%a0%94%e7%a9%b6%e6%88%90%e6%9e%9c%e3%81%8cacs-med-chem-lett%e8%aa%8c%e3%81%ab%e6%8e%b2%e8%bc%89%e3%81%95%e3%82%8c%e3%81%be%e3%81%97%e3%81%9f-%e5%a4%a7%e9%87%91%e3%81%8c%e5%85%b1%e8%91%97\/","title":{"rendered":"\u7814\u7a76\u6210\u679c\u304cACS Med Chem Lett\u8a8c\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f (\u5927\u91d1\u304c\u5171\u8457)"},"content":{"rendered":"<p><a href=\"https:\/\/www.agri.tohoku.ac.jp\/ishikawa-lab\/index.html\">\u6771\u5317\u5927\u5b66\u5927\u5b66\u9662\u751f\u547d\u79d1\u5b66\u7814\u7a76\u79d1\u30fb\u6d3b\u6027\u5206\u5b50\u52d5\u614b\u5206\u91ce<\/a>\u306e\u77f3\u5ddd\u7a14\u5148\u751f\u30fb\u53cb\u91cd\u79c0\u4ecb\u5148\u751f\u3089\u304c\u4e3b\u5c0e\u3057\u305f\u7814\u7a76\u6210\u679c\u304cACS Medicinal Chemistry Letters\u8a8c\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f (\u5927\u91d1\u304c\u5171\u8457\u306b\u5165\u3063\u3066\u3044\u307e\u3059)\u3002<\/p>\n<p>\u30dd\u30ea\u30b0\u30eb\u30bf\u30df\u30f3\u75c5\u306f\u7279\u5b9a\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u4e2d\u306b\u542b\u307e\u308c\u308b\u30b0\u30eb\u30bf\u30df\u30f3\u304c\u9023\u7d9a\u3057\u305f\u914d\u5217\u304c\u539f\u56e0\u3068\u306a\u308b\u96e3\u75c5\u3067\u3001\u30dd\u30ea\u30b0\u30eb\u30bf\u30df\u30f3\u9396\u304c\u30d9\u30fc\u30bf\u30b7\u30fc\u30c8\u69cb\u9020\u306b\u5bcc\u3093\u3060\u30aa\u30ea\u30b4\u30de\u30fc\u3084\u51dd\u96c6\u4f53\u3092\u5f62\u6210\u3059\u308b\u3053\u3068\u304c\u75c5\u56e0\u3068\u8003\u3048\u3089\u308c\u3066\u304a\u308a\u3001\u30cf\u30f3\u30c1\u30f3\u30c8\u30f3\u75c5\u306f\u305d\u306e\u4e00\u3064\u3067\u3059\u3002\u3053\u306e\u7814\u7a76\u306f\u3001\u30d9\u30fc\u30bf\u30b7\u30fc\u30c8\u69cb\u9020\u306b\u5bcc\u3093\u3060\u51dd\u96c6\u4f53\u306e\u5206\u89e3\u3092\u8a98\u5c0e\u3059\u308b\u4f4e\u5206\u5b50\u5316\u5408\u7269\u306b\u3064\u3044\u3066\u3001\u4e2d\u67a2\u79fb\u884c\u6027\u306a\u3069\u306e\u300c\u85ac\u3089\u3057\u3055\u300d\u306b\u7740\u76ee\u3057\u305f\u6539\u826f\u3092\u52a0\u3048\u305f\u7814\u7a76\u3067\u3059\u3002\u30dd\u30ea\u30b0\u30eb\u30bf\u30df\u30f3\u75c5\u3067\u306f\u4e2d\u67a2\u795e\u7d4c\u75c7\u72b6\u304c\u3042\u308b\u305f\u3081\u3001\u8133\u306a\u3069\u306e\u4e2d\u67a2\u795e\u7d4c\u7cfb\u307e\u3067\u5316\u5408\u7269\u304c\u5c4a\u304f\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u304c\u3001\u5206\u89e3\u8a98\u5c0e\u5264\u3068\u3057\u3066\u8fd1\u5e74\u76db\u3093\u306b\u7814\u7a76\u3055\u308c\u3066\u3044\u308bPROTAC\u3084SNIPER (\u6ce8\u91c8)\u3068\u3044\u3063\u305f\u5316\u5408\u7269\u306f\u6bd4\u8f03\u7684\u30b5\u30a4\u30ba\u304c\u5927\u304d\u304f\u3001\u4e2d\u67a2\u795e\u7d4c\u7cfb\u307e\u3067\u5c4a\u304d\u306b\u304f\u3044\u3068\u3044\u3046\u554f\u984c\u304c\u3042\u308a\u307e\u3057\u305f\u3002\u3053\u306e\u7814\u7a76\u3067\u306f\u3001\u5206\u89e3\u306e\u76ee\u5370\u3068\u306a\u308b\u30bf\u30b0\u3068\u3057\u3066\u3001\u30b5\u30a4\u30ba\u304c\u5927\u304d\u304f\u4e2d\u67a2\u79fb\u884c\u6027\u306b\u96e3\u306e\u3042\u308b\u30e6\u30d3\u30ad\u30c1\u30f3\u5316\u9175\u7d20\u30ea\u30ac\u30f3\u30c9\u3067\u306f\u306a\u304f\u3001\u758e\u6c34\u6027\u30bf\u30b0\u3092\u5229\u7528\u3057\u3066\u3044\u307e\u3059\u3002\u6c34\u7d20\u7d50\u5408\u6027\u3084\u5206\u5b50\u91cf\u7b49\u3092\u8003\u616e\u3057\u305f\u8a2d\u8a08\u3068\u758e\u6c34\u6027\u30bf\u30b0\u306e\u5229\u7528\u306b\u3088\u308a\u3001\u4e2d\u67a2\u79fb\u884c\u6027\u306e\u6bd4\u8f03\u7684\u9ad8\u3044\u5206\u89e3\u8a98\u5c0e\u5264\u3092\u4f5c\u308c\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>Keigo Hirai, Hiroko Yamashita, Shusuke Tomoshige*, Yugo Mishima, Tatsuya Niwa, Kenji Ohgane, Mayumi Ishii, Kayoko Kanamitsu, Yui Ikemi, Shinsaku Nakagawa, Hideki Taguchi, Shinichi Sato, Yuichi Hashimoto, and Minoru Ishikawa* (2022) <a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acsmedchemlett.1c00500\">&#8220;Conversion of a PROTAC Mutant Huntingtin Degrader into Small-Molecule Hydrophobic Tags Focusing on Drug-like Properties&#8221;<\/a>\u00a0<cite>ACS Medicinal Chemistry Letters<\/cite> <strong>Article ASAP<\/strong>,\u00a0DOI: 10.1021\/acsmedchemlett.1c00500 (\u306a\u304a\u95b2\u89a7\u306b\u306f\u6240\u5c5e\u6a5f\u95a2\u306e\u5951\u7d04\u304c\u5fc5\u8981\u3067\u3059)<\/p>\n<div id=\"attachment_196\" style=\"width: 1010px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-196\" class=\"size-full wp-image-196\" src=\"https:\/\/www-p.sci.ocha.ac.jp\/ohganelab\/wp-content\/uploads\/sites\/31\/2022\/02\/ml1c00500_0008.jpeg\" alt=\"Graphical Abstract\" width=\"1000\" height=\"546\" srcset=\"https:\/\/www-p.sci.ocha.ac.jp\/ohganelab\/wp-content\/uploads\/sites\/31\/2022\/02\/ml1c00500_0008.jpeg 1000w, https:\/\/www-p.sci.ocha.ac.jp\/ohganelab\/wp-content\/uploads\/sites\/31\/2022\/02\/ml1c00500_0008-300x164.jpeg 300w, https:\/\/www-p.sci.ocha.ac.jp\/ohganelab\/wp-content\/uploads\/sites\/31\/2022\/02\/ml1c00500_0008-768x419.jpeg 768w, https:\/\/www-p.sci.ocha.ac.jp\/ohganelab\/wp-content\/uploads\/sites\/31\/2022\/02\/ml1c00500_0008-24x13.jpeg 24w, https:\/\/www-p.sci.ocha.ac.jp\/ohganelab\/wp-content\/uploads\/sites\/31\/2022\/02\/ml1c00500_0008-36x20.jpeg 36w, https:\/\/www-p.sci.ocha.ac.jp\/ohganelab\/wp-content\/uploads\/sites\/31\/2022\/02\/ml1c00500_0008-48x26.jpeg 48w\" sizes=\"auto, (max-width: 1000px) 100vw, 1000px\" \/><p id=\"caption-attachment-196\" class=\"wp-caption-text\">Reprinted with permission from ACS Med. Chem. Lett. 2022, in press (https:\/\/doi.org\/10.1021\/acsmedchemlett.1c00500). Copyright 2022 American Chemical Society.<\/p><\/div>\n<p>\u6ce8\u91c8: PROTAC \/ SNIPER\u3068\u306f\u3001\u6a19\u7684\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u7d50\u5408\u3059\u308b\u5316\u5408\u7269\u3068\u30e6\u30d3\u30ad\u30c1\u30f3\u30ea\u30ac\u30fc\u30bc\u306b\u7d50\u5408\u3059\u308b\u5316\u5408\u7269\u3092\u30ea\u30f3\u30ab\u30fc\u3067\u3064\u306a\u3044\u3060\u5316\u5408\u7269\u3067\u3001\u6a19\u7684\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u30e6\u30d3\u30ad\u30c1\u30f3\u5316\u3068\u30d7\u30ed\u30c6\u30a2\u30bd\u30fc\u30e0\u306b\u3088\u308b\u5206\u89e3\u3092\u8d77\u3053\u3059\u5316\u5408\u7269\u306e\u7dcf\u79f0\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u6771\u5317\u5927\u5b66\u5927\u5b66\u9662\u751f\u547d\u79d1\u5b66\u7814\u7a76\u79d1\u30fb\u6d3b\u6027\u5206\u5b50\u52d5\u614b\u5206\u91ce\u306e\u77f3\u5ddd\u7a14\u5148\u751f\u30fb\u53cb\u91cd\u79c0\u4ecb\u5148\u751f\u3089\u304c\u4e3b\u5c0e\u3057\u305f\u7814\u7a76\u6210\u679c\u304cACS Medicinal Chemistry Letters\u8a8c\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f (\u5927\u91d1\u304c\u5171\u8457\u306b\u5165\u3063\u3066\u3044\u307e\u3059)\u3002 \u30dd\u30ea\u30b0\u30eb\u30bf\u30df &hellip; <a href=\"https:\/\/www-p.sci.ocha.ac.jp\/ohganelab\/2022\/02\/18\/%e7%a0%94%e7%a9%b6%e6%88%90%e6%9e%9c%e3%81%8cacs-med-chem-lett%e8%aa%8c%e3%81%ab%e6%8e%b2%e8%bc%89%e3%81%95%e3%82%8c%e3%81%be%e3%81%97%e3%81%9f-%e5%a4%a7%e9%87%91%e3%81%8c%e5%85%b1%e8%91%97\/\">\u7d9a\u304d\u3092\u8aad\u3080 <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":48,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-195","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/www-p.sci.ocha.ac.jp\/ohganelab\/wp-json\/wp\/v2\/posts\/195","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www-p.sci.ocha.ac.jp\/ohganelab\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www-p.sci.ocha.ac.jp\/ohganelab\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www-p.sci.ocha.ac.jp\/ohganelab\/wp-json\/wp\/v2\/users\/48"}],"replies":[{"embeddable":true,"href":"https:\/\/www-p.sci.ocha.ac.jp\/ohganelab\/wp-json\/wp\/v2\/comments?post=195"}],"version-history":[{"count":1,"href":"https:\/\/www-p.sci.ocha.ac.jp\/ohganelab\/wp-json\/wp\/v2\/posts\/195\/revisions"}],"predecessor-version":[{"id":197,"href":"https:\/\/www-p.sci.ocha.ac.jp\/ohganelab\/wp-json\/wp\/v2\/posts\/195\/revisions\/197"}],"wp:attachment":[{"href":"https:\/\/www-p.sci.ocha.ac.jp\/ohganelab\/wp-json\/wp\/v2\/media?parent=195"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www-p.sci.ocha.ac.jp\/ohganelab\/wp-json\/wp\/v2\/categories?post=195"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www-p.sci.ocha.ac.jp\/ohganelab\/wp-json\/wp\/v2\/tags?post=195"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}