{"id":29,"date":"2021-07-22T20:54:42","date_gmt":"2021-07-22T11:54:42","guid":{"rendered":"https:\/\/www-p.sci.ocha.ac.jp\/ohganelab_test\/?page_id=29"},"modified":"2025-04-12T11:42:37","modified_gmt":"2025-04-12T02:42:37","slug":"publications","status":"publish","type":"page","link":"https:\/\/www-p.sci.ocha.ac.jp\/ohganelab\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"<h2>\u8ad6\u6587\u30fb\u7dcf\u8aac | Articles &amp; Reviews<\/h2>\n<h3>2025<\/h3>\n<div class=\"rm-cv-list-content\">\n<ul>\n<li><strong><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0003269725000995\">In-gel refolding allows fluorescence detection of fully denatured GFPs after SDS-PAGE<\/a>.<\/strong><br \/>\n<span style=\"text-decoration: underline\">Misa Shiratori<\/span>, <span style=\"text-decoration: underline\">Rio Tsuyuki<\/span>, <span style=\"text-decoration: underline\">Miwako Asanuma<\/span>, <span style=\"text-decoration: underline\">Saki Kawabata<\/span>, Hiromasa Yoshioka, <span style=\"text-decoration: underline\">Kenji Ohgane*<\/span> (2025\u5e744\u67085\u65e5)<br \/>\nAnalytical Biochemistry 702, 115861 (2025)<br \/>\n<a href=\"https:\/\/doi.org\/10.1016\/j.ab.2025.115861\">https:\/\/doi.org\/10.1016\/j.ab.2025.115861\u00a0<\/a><br \/>\n<img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-large wp-image-436\" src=\"https:\/\/www-p.sci.ocha.ac.jp\/ohganelab\/wp-content\/uploads\/sites\/31\/2024\/11\/GraphicalAbstract_Shiratori2024-1024x445.jpg\" alt=\"\" width=\"640\" height=\"278\" srcset=\"https:\/\/www-p.sci.ocha.ac.jp\/ohganelab\/wp-content\/uploads\/sites\/31\/2024\/11\/GraphicalAbstract_Shiratori2024-1024x445.jpg 1024w, https:\/\/www-p.sci.ocha.ac.jp\/ohganelab\/wp-content\/uploads\/sites\/31\/2024\/11\/GraphicalAbstract_Shiratori2024-300x130.jpg 300w, https:\/\/www-p.sci.ocha.ac.jp\/ohganelab\/wp-content\/uploads\/sites\/31\/2024\/11\/GraphicalAbstract_Shiratori2024-768x334.jpg 768w, https:\/\/www-p.sci.ocha.ac.jp\/ohganelab\/wp-content\/uploads\/sites\/31\/2024\/11\/GraphicalAbstract_Shiratori2024-24x10.jpg 24w, https:\/\/www-p.sci.ocha.ac.jp\/ohganelab\/wp-content\/uploads\/sites\/31\/2024\/11\/GraphicalAbstract_Shiratori2024-36x16.jpg 36w, https:\/\/www-p.sci.ocha.ac.jp\/ohganelab\/wp-content\/uploads\/sites\/31\/2024\/11\/GraphicalAbstract_Shiratori2024-48x21.jpg 48w, https:\/\/www-p.sci.ocha.ac.jp\/ohganelab\/wp-content\/uploads\/sites\/31\/2024\/11\/GraphicalAbstract_Shiratori2024.jpg 1190w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/>&gt; <a href=\"https:\/\/www-p.sci.ocha.ac.jp\/ohganelab\/2025\/04\/11\/gfp\u306e\u30b2\u30eb\u5185\u30ea\u30d5\u30a9\u30fc\u30eb\u30c7\u30a3\u30f3\u30b0\u8ad6\u6587\u304canalytical-biochemistry\u8a8c\u306b\u63b2\/\">\u30cb\u30e5\u30fc\u30b9<\/a><\/li>\n<li><strong><a href=\"https:\/\/www.mdpi.com\/1422-0067\/26\/7\/3391\">Synthesis and Biological Assessment of Eucalyptin: Magic Methyl Effects<\/a><\/strong><br \/>\nKanta Fuchiyama, Yuka Yabuki, Yuzu Yamamoto, Ryuki Asakawa, Saki Matsumoto, Yuuka Ibayashi, Yuuki Furuyama, <span style=\"text-decoration: underline\">Kenji Ohgane<\/span>, Shinji Kamisuki, Koichi Watashi, Makoto Matsubayashi, Kouji Kuramochi* (2025\u5e744\u67084\u65e5)<br \/>\nInt. J. Mo. Sci. 26(7), 3391 (2025)<\/li>\n<li><strong><a href=\"https:\/\/pubs.acs.org\/doi\/full\/10.1021\/acsmedchemlett.4c00500\">Clozapine as an E3 Ligand for PROTAC Technology<\/a><\/strong><br \/>\nReina Takano, Nobumichi Ohoka*, Takashi Kurohara, Noriaki Arakawa, <span style=\"text-decoration: underline\">Kenji Ohgane<\/span>, Takao Inoue, Hidetomo Yokoo*, Yosuke Demizu* (2025\u5e741\u67088\u65e5)<br \/>\nACS Medicinal Chemistry Letters 16 (2), 258-262 (2025)<\/li>\n<\/ul>\n<h3>2024<\/h3>\n<ul>\n<li>[Preprint] <strong><a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2024.10.02.615947v1\">In-gel refolding allows fluorescence detection of fully denatured GFPs after SDS-PAGE<\/a>.<\/strong><br \/>\n<span style=\"text-decoration: underline\">Misa Shiratori<\/span>, <span style=\"text-decoration: underline\">Rio Tsuyuki<\/span>, <span style=\"text-decoration: underline\">Miwako Asanuma<\/span>, <span style=\"text-decoration: underline\">Saki Kawabata<\/span>, Hiromasa Yoshioka, <span style=\"text-decoration: underline\">Kenji Ohgane*<\/span><br \/>\nbioRxiv, <span class=\"label\">doi:<\/span> https:\/\/doi.org\/10.1101\/2024.10.02.615947<br \/>\n&gt; <a href=\"https:\/\/www-p.sci.ocha.ac.jp\/ohganelab\/2024\/10\/06\/gfp\u306e\u30b2\u30eb\u5185\u30ea\u30d5\u30a9\u30fc\u30eb\u30c7\u30a3\u30f3\u30b0\u306e\u8ad6\u6587\u304cbiorxiv\u3067\u516c\u958b\/\">\u30cb\u30e5\u30fc\u30b9<\/a><\/li>\n<li><strong>Plakevulin A induces apoptosis and suppresses IL-6-induced STAT3 activation in HL60 cells.<\/strong><br \/>\nMisaki Kabasawa, Masateru Furuta, Yuuka Ibayashi, Kaori Kanemaru, Haruki Kohatsu, Fumiyo Kuramochi, Kenji Yamatoya, Kazuya Nakata, Yoshikazu Nakamura, Shusuke Tomoshige, <span style=\"text-decoration: underline\">Kenji Ohgane<\/span>, Yuuki Furuyama, Ryoko Takasawa, Susumu Kobayashi, Fumio Sugawara, Masahiko Ikekita, Kouji Kuramochi* (2024\u5e749\u670815\u65e5)<br \/>\nBioorganic &amp; medicinal chemistry letters 110, 129886<\/li>\n<li><strong><a class=\"rm-cv-list-title\" href=\"https:\/\/doi.org\/10.1172\/jci.insight.179525\">Mutant induced neurons and humanized mice enable identification of Niemann-Pick C1 proteostatic therapies.<\/a> <\/strong><br \/>\nRuth D Azaria, Adele B Correia, Kylie J Schache, Manuela Zapata, Koralege C Pathmasiri, Varshasnata Mohanty, Dharma T Nannapaneni, Brandon L Ashfeld, Paul Helquist, Olaf Wiest, <span style=\"text-decoration: underline\">Kenji Ohgane<\/span>, Qingqing Li, Ross A Fredenburg, Brian Sj Blagg, Stephanie M Cologna, Mark L Schultz*, Andrew P Lieberman*<br \/>\nJCI insight (Open Access) (2024\u5e748\u670829\u65e5)<br \/>\n&gt; <a href=\"https:\/\/www-p.sci.ocha.ac.jp\/ohganelab\/2024\/10\/24\/\u5927\u91d1\u304c\u5171\u8457\u306e\u8ad6\u6587\u304cjci-insight\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\/\">\u30cb\u30e5\u30fc\u30b9<\/a><\/li>\n<\/ul>\n<\/div>\n<ul>\n<li>\n<div><strong><a class=\"rm-cv-list-title\" href=\"https:\/\/doi.org\/10.1016\/j.bmc.2024.117789\">A small-molecule degron with a phenylpropionic acid scaffold<\/a>\u00a0<\/strong><\/div>\n<div class=\"rm-cv-list-author\">Shusuke Tomoshige*, Fumiko Komatsu, Tomoko Kikuchi, Miku Sugiyama, Yushi Kawasaki, <span style=\"text-decoration: underline\">Kenji Ohgane<\/span>, Yuuki Furuyama, Shinichi Sato, Minoru Ishikawa, Kouji Kuramochi<\/div>\n<div>Bioorganic &amp; Medicinal Chemistry 109, 117789-117789 2024\u5e746\u6708<\/div>\n<\/li>\n<\/ul>\n<h3>2023<\/h3>\n<ul>\n<li><span class=\"csl-entry\"><strong><a href=\"https:\/\/www.cell.com\/cell-reports\/fulltext\/S2211-1247(23)00399-6?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2211124723003996%3Fshowall%3Dtrue\">Lysine long-chain fatty acylation regulates the TEAD transcription factor<\/a><\/strong><br \/>\n<\/span><span class=\"csl-entry\">Kota Noritsugu, Takehiro Suzuki, Kosuke Dodo, <span style=\"text-decoration: underline\">Kenji Ohgane<\/span>, Yasue Ichikawa, Kota Koike, Satoshi Morita, Takashi Umehara, Kenji Ogawa, Mikiko Sodeoka, Naoshi Dohmae, Minoru Yoshida*, Akihiro Ito*<br \/>\n<\/span><span class=\"csl-entry\"><i>Cell Reports<\/i> 42, 112388, 2023\u5e744\u6708 (Open Access)<br \/>\nDOI: <a href=\"https:\/\/doi.org\/10.1016\/j.celrep.2023.112388\">10.1016\/j.celrep.2023.112388<\/a><br \/>\n<img loading=\"lazy\" decoding=\"async\" class=\"aligncenter\" src=\"https:\/\/ars.els-cdn.com\/content\/image\/1-s2.0-S2211124723003996-fx1_lrg.jpg\" width=\"335\" height=\"335\" \/><br \/>\n<\/span><\/li>\n<\/ul>\n<h3>2022<\/h3>\n<ul>\n<li>\n<div class=\"csl-entry\"><strong><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0968089622005387\">Fine-tuning of nitrogen-containing bisphosphonate esters that potently induce degradation of HMG-CoA reductase<\/a><\/strong><br \/>\nKota Kawamura, Hiromasa Yoshioka, Chikako Sato, Tomoko Yajima, Yuuki Furuyama, Kouji Kuramochi, Kenji Ohgane*<br \/>\n<i>Bioorg Med Chem <\/i><strong>78<\/strong>, 117145, 2022\u5e7412\u6708<br \/>\nDOI:\u00a010.1016\/j.bmc.2022.117145<br \/>\nPreprint (SSRN): <a href=\"https:\/\/ssrn.com\/abstract=4285357\">https:\/\/ssrn.com\/abstract=4285357<\/a><br \/>\n<a href=\"https:\/\/www-p.sci.ocha.ac.jp\/ohganelab\/wp-content\/uploads\/sites\/31\/2022\/12\/Kawamura2022_BMC_GraphicalAbstract_Kawamura.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-289 size-large\" src=\"https:\/\/www-p.sci.ocha.ac.jp\/ohganelab\/wp-content\/uploads\/sites\/31\/2022\/12\/Kawamura2022_BMC_GraphicalAbstract_Kawamura-1024x255.jpg\" alt=\"\" width=\"640\" height=\"159\" srcset=\"https:\/\/www-p.sci.ocha.ac.jp\/ohganelab\/wp-content\/uploads\/sites\/31\/2022\/12\/Kawamura2022_BMC_GraphicalAbstract_Kawamura-1024x255.jpg 1024w, https:\/\/www-p.sci.ocha.ac.jp\/ohganelab\/wp-content\/uploads\/sites\/31\/2022\/12\/Kawamura2022_BMC_GraphicalAbstract_Kawamura-300x75.jpg 300w, https:\/\/www-p.sci.ocha.ac.jp\/ohganelab\/wp-content\/uploads\/sites\/31\/2022\/12\/Kawamura2022_BMC_GraphicalAbstract_Kawamura-768x191.jpg 768w, https:\/\/www-p.sci.ocha.ac.jp\/ohganelab\/wp-content\/uploads\/sites\/31\/2022\/12\/Kawamura2022_BMC_GraphicalAbstract_Kawamura-24x6.jpg 24w, https:\/\/www-p.sci.ocha.ac.jp\/ohganelab\/wp-content\/uploads\/sites\/31\/2022\/12\/Kawamura2022_BMC_GraphicalAbstract_Kawamura-36x9.jpg 36w, https:\/\/www-p.sci.ocha.ac.jp\/ohganelab\/wp-content\/uploads\/sites\/31\/2022\/12\/Kawamura2022_BMC_GraphicalAbstract_Kawamura-48x12.jpg 48w, https:\/\/www-p.sci.ocha.ac.jp\/ohganelab\/wp-content\/uploads\/sites\/31\/2022\/12\/Kawamura2022_BMC_GraphicalAbstract_Kawamura.jpg 1321w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/a><\/div>\n<\/li>\n<li class=\"list-group-item rm-cv-disclosed rm-cv-type-myself rm-cv-modified\">\n<div class=\"rm-cv-list-content\">\n<div><strong><a class=\"rm-cv-list-title\" href=\"https:\/\/researchmap.jp\/k_ohgane\/published_papers\/39888262\">Synthesis and cytotoxic activities of 8-and 6-demethyleucalyptins<\/a><\/strong><\/div>\n<div class=\"rm-cv-list-author\">Ryuki Asakawa, Kanta Fuchiyama, Yunosuke Ishii, Keisuke Hosaka, Atsushi Kobayashi, Kei Shimazaki, Junki Nagasawa, Sayaka Tsuchida, Kazunari Ushida, Makoto Matsubayashi, Yuuki Furuyama, Kenji Ohgane, Kouji Kuramochi*<\/div>\n<div>BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY\u00a086(9) 1200-1206\u00a02022\u5e748\u670824\u65e5<\/div>\n<\/div>\n<\/li>\n<li><strong><span style=\"text-decoration: underline\"><a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acsmedchemlett.1c00500\">Conversion of a PROTAC Mutant Huntingtin Degrader into Small-Molecule Hydrophobic Tags Focusing on Drug-like Properties<\/a><\/span><\/strong><br \/>\nKeigo Hirai, Hiroko Yamashita, Shusuke Tomoshige*, Yugo Mishima, Tatsuya Niwa, Kenji Ohgane, Mayumi Ishii, Kayoko Kanamitsu, Yui Ikemi, Shinsaku Nakagawa, Hideki Taguchi, Shinichi Sato, Yuichi Hashimoto, and Minoru Ishikawa*<br \/>\n<cite>ACS Medicinal Chemistry Letters <\/cite><strong>13(3)<\/strong>, 396-402, 2022\u5e742\u6708<br \/>\nDOI: 10.1021\/acsmedchemlett.1c00500<br \/>\n<a href=\"https:\/\/www-p.sci.ocha.ac.jp\/ohganelab\/wp-content\/uploads\/sites\/31\/2022\/12\/Hirai_2022_ACSMedChemLett.jpeg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-medium wp-image-291\" src=\"https:\/\/www-p.sci.ocha.ac.jp\/ohganelab\/wp-content\/uploads\/sites\/31\/2022\/12\/Hirai_2022_ACSMedChemLett-300x164.jpeg\" alt=\"\" width=\"300\" height=\"164\" srcset=\"https:\/\/www-p.sci.ocha.ac.jp\/ohganelab\/wp-content\/uploads\/sites\/31\/2022\/12\/Hirai_2022_ACSMedChemLett-300x164.jpeg 300w, https:\/\/www-p.sci.ocha.ac.jp\/ohganelab\/wp-content\/uploads\/sites\/31\/2022\/12\/Hirai_2022_ACSMedChemLett-768x419.jpeg 768w, https:\/\/www-p.sci.ocha.ac.jp\/ohganelab\/wp-content\/uploads\/sites\/31\/2022\/12\/Hirai_2022_ACSMedChemLett-24x13.jpeg 24w, https:\/\/www-p.sci.ocha.ac.jp\/ohganelab\/wp-content\/uploads\/sites\/31\/2022\/12\/Hirai_2022_ACSMedChemLett-36x20.jpeg 36w, https:\/\/www-p.sci.ocha.ac.jp\/ohganelab\/wp-content\/uploads\/sites\/31\/2022\/12\/Hirai_2022_ACSMedChemLett-48x26.jpeg 48w, https:\/\/www-p.sci.ocha.ac.jp\/ohganelab\/wp-content\/uploads\/sites\/31\/2022\/12\/Hirai_2022_ACSMedChemLett.jpeg 1000w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/li>\n<li><strong><a href=\"https:\/\/doi.org\/10.1021\/acs.jnatprod.1c01120\">Synthesis and Antiviral Activities of Neoechinulin B and Its Derivatives.<\/a><\/strong><br \/>\nKota Nishiuchi, Hirofumi Ohashi, Kazane Nishioka, Masako Yamasaki, Masateru Furuta, Takumi Mashiko, Shusuke Tomoshige, Kenji Ohgane, Shinji Kamisuki, Koichi Watashi, Kouji Kuramochi*<br \/>\nJournal of Natural Products <i>85<\/i>, 284\u2013291,\u00a02022\u5e741\u670828\u65e5<\/li>\n<\/ul>\n<h3>2021<\/h3>\n<ul>\n<li><strong><a href=\"https:\/\/doi.org\/10.1039\/d1ob01479j\">Deuteration of terminal alkynes realizes simultaneous live cell Raman imaging of similar alkyne-tagged biomolecules.<\/a><\/strong><br \/>\nSyusuke Egoshi, Kosuke Dodo, Kenji Ohgane, Mikiko Sodeoka<br \/>\nOrganic &amp; Biomolecular Chemistry 19(38) 8232-8236 2021\u5e749\u6708<\/li>\n<li><strong><a href=\"https:\/\/doi.org\/10.1016\/j.tetlet.2021.153519\">Deoxygenation of tertiary and secondary alcohols with sodium borohydride, trimethylsilyl chloride, and potassium iodide in acetonitrile<\/a><\/strong><br \/>\nYuichi Kato, Tomoka Inoue, Yuuki Furuyama, Kenji Ohgane, Mahito Sadaie, Kouji Kuramochi<br \/>\nTETRAHEDRON LETTERS 86 2021\u5e7412\u6708<\/li>\n<li><strong><a href=\"https:\/\/doi.org\/10.1016\/j.bmc.2021.116203\">Epo-C12 inhibits peroxiredoxin 1 peroxidase activity.<\/a><\/strong><br \/>\nTomoka Yoda, Masateru Furuta, Tomohiko Tsutsumi, Seiki Ikeda, Shunsuke Yukizawa, Satoshi Arai, Akinori Morita, Kenji Yamatoya, Kazuya Nakata, Shusuke Tomoshige, Kenji Ohgane, Yuuki Furuyama, Kengo Sakaguchi, Fumio Sugawara, Susumu Kobayashi, Masahiko Ikekita, Kouji Kuramochi<br \/>\nBioorganic &amp; medicinal chemistry 41 116203-116203 2021\u5e747\u67081\u65e5<\/li>\n<\/ul>\n<h3>2020<\/h3>\n<ul>\n<li><strong><a href=\"https:\/\/doi.org\/10.1371\/journal.pone.0243746\">Image-based screen capturing misfolding status of Niemann-Pick type C1 identifies potential candidates for chaperone drugs<\/a><\/strong><br \/>\nRyuta Shioi, Fumika Karaki, Hiromasa Yoshioka, Tomomi Noguchi-Yachide, Minoru Ishikawa, Kosuke Dodo, Yuichi Hashimoto, Mikiko Sodeoka, Kenji Ohgane*<br \/>\nPLOS ONE 15(12) e0243746-e0243746 2020\u5e7412\u670814\u65e5<\/li>\n<li><strong><a href=\"https:\/\/doi.org\/10.1016\/j.bmc.2020.115576\">Bisphosphonate esters interact with HMG-CoA reductase membrane domain to induce its degradation<\/a><\/strong><br \/>\nYosuke Toyota, Hiromasa Yoshioka, Ikuya Sagimori, Yuichi Hashimoto, Kenji Ohgane*<br \/>\nBioorganic &amp; Medicinal Chemistry 28(14) 115576-115576 2020\u5e745\u6708<\/li>\n<li><strong><a href=\"https:\/\/doi.org\/10.1073\/pnas.1915923117\">A key mammalian cholesterol synthesis enzyme, squalene monooxygenase, is allosterically stabilized by its substrate<\/a><\/strong><br \/>\nHiromasa Yoshioka, Hudson W. Coates, Ngee Kiat Chua, Yuichi Hashimoto, Andrew J. Brown*, Kenji Ohgane*<br \/>\nProceedings of the National Academy of Sciences 117(13) 7150-7158 2020\u5e743\u670831\u65e5<\/li>\n<li><strong><a href=\"https:\/\/doi.org\/10.1016\/j.bmc.2019.115298\">Luciferase-based HMG-CoA reductase degradation assay for activity and selectivity profiling of oxy(lano)sterols<\/a><\/strong><br \/>\nIkuya Sagimori, Hiromasa Yoshioka, Yuichi Hashimoto, Kenji Ohgane*<br \/>\nBioorganic &amp; Medicinal Chemistry 28(3) 115298-115298 2020\u5e742\u6708<\/li>\n<\/ul>\n<h3>2019<\/h3>\n<ul>\n<li><strong>Application of Protein Knockdown Strategy Targeting \u03b2-Sheet Structure to Multiple Disease-associated Polyglutamine Proteins<\/strong><br \/>\nHiroko Yamashita, Shusuke Tomoshige, Sayaka Nomura, Kenji Ohgane, Yuichi Hashimoto, Minoru Ishikawa*<br \/>\nBioorganic &amp; Medicinal Chemistry 28(1) 115175 2019\u5e7410\u6708<\/li>\n<li><strong>Structure-activity relationship study of estrogen receptor down-regulators with a diphenylmethane skeleton.<\/strong><br \/>\nNanjyo S, Ohgane K, Yoshioka H, Makishima M, Hashimoto Y, Noguchi-Yachide T*<br \/>\nBioorganic &amp; medicinal chemistry 27(10) 1952-1961 2019\u5e745\u6708<\/li>\n<li><strong>Multiplexing fluorogenic esterase-based viability assay with luciferase assays<\/strong><br \/>\nKenji Ohgane*, Hiromasa Yoshioka, Yuichi Hashimoto<br \/>\nMethodsX 6 2013-2020 2019\u5e74<\/li>\n<\/ul>\n<h3>2018<\/h3>\n<ul>\n<li><strong>Degradation of huntingtin mediated by a hybrid molecule composed of IAP antagonist linked to phenyldiazenyl benzothiazole derivative<\/strong><br \/>\nShusuke Tomoshige, Sayaka Nomura, Kenji Ohgane, Yuichi Hashimoto, Minoru Ishikawa*<br \/>\nBioorganic and Medicinal Chemistry Letters 28(4) 707-710 2018\u5e742\u670815\u65e5<\/li>\n<li><strong>Unexpected emergence of luciferase-inhibitory activity during structural development study of phenyloxadiazole-based PPAR ligands<\/strong><br \/>\nShioi R, Toyota Y, Noguchi-Yachide T, Ishikawa M, Yamaguchi T, Makishima M, Hashimoto Y, Ohgane K*<br \/>\nHeterocycles 97(2) 854-864 2018\u5e74<\/li>\n<\/ul>\n<h3>2017<\/h3>\n<ul>\n<li><strong>Discovery of Small Molecules that Induce the Degradation of Huntingtin<\/strong><br \/>\nShusuke Tomoshige, Sayaka Nomura, Kenji Ohgane, Yuichi Hashimoto, Minoru Ishikawa<br \/>\nANGEWANDTE CHEMIE-INTERNATIONAL EDITION 56(38) 11530-11533 2017\u5e749\u6708<\/li>\n<li><strong>Reactivity of 7-Azanorbornenes in Bioorthogonal Inverse Electron-Demand Diels-Alder Reactions<\/strong><br \/>\nFumika Karaki, Kenji Ohgane, Hirotaka Imai, Kennosuke Itoh, Hideaki Fujii<br \/>\nEUROPEAN JOURNAL OF ORGANIC CHEMISTRY 2017(26) 3815-3829 2017\u5e747\u6708<\/li>\n<li><strong>Phenanthridin-6-one derivatives as the first class of non-steroidal pharmacological chaperones for Niemann-Pick disease type C1 protein<\/strong><br \/>\nHiromitsu Fukuda, Fumika Karaki, Kosuke Dodo, Tomomi Noguchi-Yachide, Minoru Ishikawa, Yuichi Hashimoto, Kenji Ohgane<br \/>\nBIOORGANIC &amp; MEDICINAL CHEMISTRY LETTERS 27(12) 2781-2787 2017\u5e746\u6708<\/li>\n<\/ul>\n<h3>2014<\/h3>\n<ul>\n<li><strong>Structure-activity relationships of oxysterol-derived pharmacological chaperones for Niemann-Pick type C1 protein<\/strong><br \/>\nKenji Ohgane, Fumika Karaki, Tomomi Noguchi-Yachide, Kosuke Dodo, Yuichi Hashimoto<br \/>\nBIOORGANIC &amp; MEDICINAL CHEMISTRY LETTERS 24(15) 3480-3485 2014\u5e748\u6708<\/li>\n<li><strong>Structure-activity relationship study of non-steroidal NPC1L1 ligands identified through cell-based assay using pharmacological chaperone effect as a readout<\/strong><br \/>\nFumika Karaki, Kenji Ohgane, Hiromitsu Fukuda, Masahiko Nakamura, Kosuke Dodo, Yuichi Hashimoto<br \/>\nBIOORGANIC &amp; MEDICINAL CHEMISTRY 22(14) 3587-3609 2014\u5e747\u6708<\/li>\n<\/ul>\n<h3>~2013<\/h3>\n<ul>\n<li><strong>Structure-activity relationship studies of Niemann-Pick type C1-like 1 (NPC1L1) ligands identified by screening assay monitoring pharmacological chaperone effect<\/strong><br \/>\nFumika Karaki, Kenji Ohgane, Kosuke Dodo, Yuichi Hashimoto<br \/>\nBIOORGANIC &amp; MEDICINAL CHEMISTRY 21(17) 5297-5309 2013\u5e749\u6708<\/li>\n<li><strong>Discovery of Oxysterol-Derived Pharmacological Chaperones for NPC1: Implication for the Existence of Second Sterol-Binding Site<\/strong><br \/>\nKenji Ohgane, Fumika Karaki, Kosuke Dodo, Yuichi Hashimoto<br \/>\nCHEMISTRY &amp; BIOLOGY 20(3) 391-402 2013\u5e743\u6708<\/li>\n<li><strong>Design, Synthesis, and Biological Evaluation of Novel Transrepression-Selective Liver X Receptor (LXR) Ligands with 5,11-Dihydro-5-methyl-11-methylene-6H-dibenz[b,e]azepin-6-one Skeleton<\/strong><br \/>\nAtsushi Aoyama, Kaori Endo-Umeda, Kenji Kishida, Kenji Ohgane, Tomomi Noguchi-Yachide, Hiroshi Aoyama, Minoru Ishikawa, Hiroyuki Miyachi, Makoto Makishima, Yuichi Hashimoto<br \/>\nJOURNAL OF MEDICINAL CHEMISTRY 55(17) 7360-7377 2012\u5e749\u6708<\/li>\n<li><strong>Bidirectional fluorescence properties of pyrene-based peroxisome proliferator-activated receptor (PPAR) \u03b1\/\u03b4 dual agonist.<\/strong><br \/>\nBan Shintaro, Oyama Takuji, Kasuga Jun-ichi, Ohgane Kenji, Nishio Yoshino, Morikawa Kosuke, Hashimoto Yuichi, Miyachi Hiroyuki<br \/>\nBioorganic &amp; medicinal chemistry 20(11) 3460-3464 2012\u5e746\u6708<\/li>\n<li><strong>Structural Development Study of a Novel Pharmacological Chaperone for Folding-defective Rhodopsin Mutants Responsible for Retinitis Pigmentosa<\/strong><br \/>\nKenji Ohgane, Kosuke Dodo, Yuichi Hashimoto<br \/>\nYAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN 131(3) 325-334 2011\u5e743\u6708<\/li>\n<li><strong>Retinobenzaldehydes as proper-trafficking inducers of folding-defective P23H rhodopsin mutant responsible for Retinitis Pigmentosa<\/strong><br \/>\nKenji Ohgane, Kosuke Dodo, Yuichi Hashimoto<br \/>\nBIOORGANIC &amp; MEDICINAL CHEMISTRY 18(19) 7022-7028 2010\u5e7410\u6708<\/li>\n<li><strong>Peroxisome proliferator-activated receptor (PPAR) agonists with 3,4-dihydro-2H-benzo[e][1,3]oxazine and 2,3,4,5-tetrahydrobenzo[f][1,4]oxazepine skeletons: Effects of cyclization of linker moiety on PPAR-agonistic activity<\/strong><br \/>\nKenji Ohgane, Jyun-ichi Kasuga, Takuji Ohyama, Yuko Hirakawa, Kosuke Morikawa, Makoto Makishima, Yuichi Hashimoto, Hiroyuki Miyachi<br \/>\nHETEROCYCLES 75(9) 2187-2192 2008\u5e749\u6708<\/li>\n<\/ul>\n<h2>\u66f8\u7c4d\u30fb\u4e00\u822c\u8a8c\u30fb\u5b66\u4f1a\u8a8c | Books<\/h2>\n<h3>2021~<\/h3>\n<ul>\n<li>\u751f\u4f53\u5206\u5b50\u3068\u75be\u60a3 : \u30d8\u30eb\u30b9\u30b5\u30a4\u30a8\u30f3\u30b9\u306e\u5207\u308a\u672d\u3068\u3057\u3066\u306e\u5316\u5b66 (\u65e5\u672c\u5316\u5b66\u4f1a\u7de8), \u5206\u62c5\u57f7\u7b46 (\u5927\u91d1\u8ce2\u53f8, \u6a4b\u672c\u7950\u4e00), Part II \u7b2c5\u7ae0\u300c\u5909\u7570\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u907a\u4f1d\u6027\u30d5\u30a9\u30fc\u30eb\u30c7\u30a3\u30f3\u30b0\u7570\u5e38\u75c7,\u00a0\u5316\u5b66\u540c\u4eba, ISBN:9784759813999<\/li>\n<li>\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u751f\u5408\u6210\u306e\u65b0\u305f\u306a\u5236\u5fa1\u30dd\u30a4\u30f3\u30c8\u2015\u30b9\u30af\u30a2\u30ec\u30f3\u30e2\u30ce\u30aa\u30ad\u30b7\u30b2\u30ca\u30fc\u30bc\u306e\u57fa\u8cea\u306b\u3088\u308b\u30a2\u30ed\u30b9\u30c6\u30ea\u30c3\u30af\u306a\u5b89\u5b9a\u5316\u2015,\u00a0\u5927\u91d1 \u8ce2\u53f8, \u5409\u5ca1 \u5e83\u5927,\u00a0\u751f\u5316\u5b66 93 147-151 2021\u5e742\u6708<\/li>\n<\/ul>\n<h3>~2020<\/h3>\n<ul>\n<li>\u819c\u30bf\u30f3\u30d1\u30af\u8cea\u5de5\u5b66\u30cf\u30f3\u30c9\u30d6\u30c3\u30af (\u76e3\u4fee: \u6d25\u672c\u6d69\u5e73\u3001\u6d5c\u7aaa\u9686\u96c4), \u5206\u62c5\u57f7\u7b46 (\u5927\u91d1\u8ce2\u53f8), \u7b2c2\u7de8-\u7b2c2\u7ae0-\u7b2c2\u7bc0\u300c\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u8f38\u9001\u4f53NPC1\u306e\u6a5f\u80fd\u30fb\u69cb\u9020\u30fb\u533b\u85ac\u6a19\u7684\u3068\u3057\u3066\u306e\u53ef\u80fd\u6027\u300d,\u00a0\u30a8\u30cc\u30fb\u30c6\u30a3\u30fc\u30fb\u30a8\u30b9, ISBN:9784860435370, 2020\u5e74<\/li>\n<li>\u30bf\u30ad\u30bd\u30fc\u30eb\u8a98\u5c0e\u4f53\u306e\u65b0\u305f\u306a\u6709\u7528\u6027:\u307b\u4e73\u985e\u7d30\u80de\u306b\u304a\u3051\u308b\u534a\u6570\u4f53\u7d30\u80de\u306e\u7dad\u6301,\u00a0\u5927\u91d1 \u8ce2\u53f8,\u00a0\u30d5\u30a1\u30eb\u30de\u30b7\u30a2 56(4) 345-345, 2020\u5e74<\/li>\n<li>\u7279\u96c6: \u6a19\u7684\u86cb\u767d\u8cea\u306e\u69cb\u9020\u3092\u5b89\u5b9a\u5316\u3059\u308b\u30b7\u30e3\u30da\u30ed\u30f3\u85ac (\u53d6\u6750\u5354\u529b\u30fb\u30a4\u30f3\u30bf\u30d3\u30e5\u30fc),\u00a0\u65e5\u7d4c\u30d0\u30a4\u30aa\u30c6\u30af 2019.4.22 4-8 2019\u5e744\u6708<\/li>\n<li>\u795e\u7d4c\u5909\u6027\u75be\u60a3\u539f\u56e0\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u30b1\u30df\u30ab\u30eb\u30ce\u30c3\u30af\u30c0\u30a6\u30f3,\u00a0\u77f3\u5ddd\u7a14, \u53cb\u91cd\u79c0\u4ecb, \u91ce\u6751\u3055\u3084\u304b, \u5c71\u4e0b\u535a\u5b50, \u5927\u91d1 \u8ce2\u53f8,\u00a0MEDCHEM NEWS 28(2) 88-92, 2018\u5e74<\/li>\n<li>\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u6298\u308a\u7573\u307f\u306e\u7570\u5e38\u3092\u76f4\u3059 \u30d5\u30a1\u30fc\u30de\u30b3\u30ed\u30b8\u30ab\u30eb\u30b7\u30e3\u30da\u30ed\u30f3\u2015\u30cb\u30fc\u30de\u30f3\u30d4\u30c3\u30af\u75c5C\u578b\u6cbb\u7642\u85ac\u3092\u76ee\u6307\u3057\u305f\u53d6\u7d44\u307f\u2015,\u00a0\u5927\u91d1\u8ce2\u53f8, \u5510\u6728\u6587\u971e, \u3069\u3069\u5b5d\u4ecb, \u6a4b\u672c\u7950\u4e00,\u00a0\u73fe\u4ee3\u5316\u5b66 (512) 48-54, 2013\u5e7411\u6708<\/li>\n<\/ul>\n<h2>\u7279\u8a31 | Patents<\/h2>\n<ul>\n<li>\u30a2\u30eb\u30ad\u30f3\u542b\u6709\u5206\u5b50\u306e\u6fc3\u7e2e\u7cbe\u88fd\u65b9\u6cd5,\u00a0\u8896\u5ca1\u5e79\u5b50, \u5927\u91d1 \u8ce2\u53f8, \u3069\u3069\u5b5d\u4ecb, \u6dfa\u6cbc\u4e09\u548c\u5b50,\u00a0\u7279\u98582016-193807 2016\u5e749\u670830\u65e5<\/li>\n<li>\u30cb\u30fc\u30de\u30f3\u30d4\u30c3\u30af\u75c5C\u578b\u4e88\u9632\u53ca\u3073\/\u53c8\u306f\u6cbb\u7642\u5264,\u00a0\u5927\u91d1 \u8ce2\u53f8, \u8896\u5ca1 \u5e79\u5b50,\u00a0\u7279\u98582015-242513, 2015\u5e7412\u670811\u65e5<\/li>\n<li>\u30d9\u30f3\u30ba\u30a2\u30eb\u30c7\u30d2\u30c9\u5316\u5408\u7269,\u00a0\u6a4b\u672c \u7950\u4e00, \u5927\u91d1 \u8ce2\u53f8,\u00a0\u7279\u98582009-148965 2009\u5e746\u670823\u65e5<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>\u8ad6\u6587\u30fb\u7dcf\u8aac | Articles &amp; Reviews 2025 In-gel refolding allows fluorescence detection of fully denatured GFPs aft &hellip; <a href=\"https:\/\/www-p.sci.ocha.ac.jp\/ohganelab\/publications\/\">\u7d9a\u304d\u3092\u8aad\u3080 <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":43,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-29","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www-p.sci.ocha.ac.jp\/ohganelab\/wp-json\/wp\/v2\/pages\/29","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www-p.sci.ocha.ac.jp\/ohganelab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www-p.sci.ocha.ac.jp\/ohganelab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www-p.sci.ocha.ac.jp\/ohganelab\/wp-json\/wp\/v2\/users\/43"}],"replies":[{"embeddable":true,"href":"https:\/\/www-p.sci.ocha.ac.jp\/ohganelab\/wp-json\/wp\/v2\/comments?post=29"}],"version-history":[{"count":13,"href":"https:\/\/www-p.sci.ocha.ac.jp\/ohganelab\/wp-json\/wp\/v2\/pages\/29\/revisions"}],"predecessor-version":[{"id":450,"href":"https:\/\/www-p.sci.ocha.ac.jp\/ohganelab\/wp-json\/wp\/v2\/pages\/29\/revisions\/450"}],"wp:attachment":[{"href":"https:\/\/www-p.sci.ocha.ac.jp\/ohganelab\/wp-json\/wp\/v2\/media?parent=29"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}