{"id":43,"date":"2015-08-11T14:55:22","date_gmt":"2015-08-11T05:55:22","guid":{"rendered":"http:\/\/www-p.cc.ocha.ac.jp\/bio-atuko\/?page_id=43"},"modified":"2025-11-03T10:24:34","modified_gmt":"2025-11-03T01:24:34","slug":"research","status":"publish","type":"page","link":"https:\/\/www-p.sci.ocha.ac.jp\/chem-aikawa-lab\/research.html","title":{"rendered":"\u7814\u7a76\u5185\u5bb9"},"content":{"rendered":"<h4><strong>\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u6d3b\u6027\u767a\u73fe\u3084\u69cb\u9020\u7279\u6027\u306b\u304a\u3051\u308b\u7cd6\u9396\u4fee\u98fe\u306e\u5f79\u5272\u3092\u3001\u751f\u5316\u5b66\u3001\u7d30\u80de\u751f\u7269\u5b66\u3001\u907a\u4f1d\u5b50\u5de5\u5b66\u306e\u624b\u6cd5\u3092\u4f7f\u3063\u3066\u8abf\u3079\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u30ec\u30af\u30c1\u30f3\u306e\u751f\u7269\u5b66\u7684\u5f79\u5272\u306e\u89e3\u660e\u3068\u305d\u306e\u5fdc\u7528\u3082\u7814\u7a76\u5bfe\u8c61\u3068\u3057\u3066\u3044\u307e\u3059\u3002\u4ee5\u4e0b\u304c\u73fe\u5728\u9032\u3081\u3066\u3044\u308b\u7814\u7a76\u30c6\u30fc\u30de\u3068\u305d\u306e\u6982\u8981\u3067\u3059\u3002<\/strong><\/h4>\n<h2 class=\"r_title\" style=\"text-align: left\">\u30ec\u30af\u30c1\u30f3ZG16p\u306e\u5927\u8178\u304c\u3093\u7d30\u80de\u306e\u5897\u6b96\u6291\u5236\u6a5f\u69cb<\/h2>\n<p style=\"text-align: left\">\u3000ZG16p\u306f\u30d8\u30d1\u30ea\u30f3\/\u3078\u30d1\u30e9\u30f3\u786b\u9178\u3084\u30de\u30f3\u30ce\u30fc\u30b9\u306b\u7d50\u5408\u3059\u308b\u30ec\u30af\u30c1\u30f3\u3067\u3001\u5927\u8178\u4e0a\u76ae\u7d30\u80de\u306b\u9ad8\u304f\u767a\u73fe\u3055\u308c\u3066\u304a\u308a\u3001\u5927\u8178\u7c98\u819c\u306e\u30e0\u30c1\u30f3\u5c64\u306b\u5c40\u5728\u3057\u3066\u3044\u308b\u3002\u79c1\u305f\u3061\u306f\u3053\u308c\u307e\u3067\u306b\u3001ZG16p\u306b\u5927\u8178\u304c\u3093\u7d30\u80de\u306e\u5897\u6b96\u6291\u5236\u4f5c\u7528\u304c\u3042\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u3066\u304a\u308a(doi: 10.1093\/glycob\/cwx088)\u3001\u73fe\u5728\u306f\u305d\u306e\u6a5f\u69cb\u306e\u89e3\u660e\u3092\u9032\u3081\u3066\u3044\u307e\u3059\u3002<\/p>\n<h2 class=\"r_title\" style=\"text-align: left\">\u00a0\u8840\u6db2\u51dd\u56faXII\u56e0\u5b50\u306e\u63a5\u89e6\u6d3b\u6027\u5316\u306b\u304a\u3051\u308b\u7cd6\u9396\u4fee\u98fe\u306e\u5f79\u5272<\/h2>\n<p style=\"text-align: left\">\u3000\u8840\u6db2\u51dd\u56faXII\u56e0\u5b50(FXII)\u306f\u5185\u56e0\u7cfb\u51dd\u56fa\u7d4c\u8def\u3067\u306f\u3058\u3081\u306b\u6d3b\u6027\u5316\u3055\u308c\u308b\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u524d\u99c6\u4f53\u3067\u3001\u8ca0\u96fb\u8377\u6027\u7269\u8cea\u3068\u7d50\u5408\u3059\u308b\u3053\u3068\u3067\u81ea\u5df1\u3092\u5207\u65ad\u3057\u3001\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u3068\u3057\u3066\u6d3b\u6027\u5316\u3059\u308b(\u63a5\u89e6\u6d3b\u6027\u5316)\u3002FXII\u306e\u6d3b\u6027\u5316\u306f\u8840\u6db2\u51dd\u56fa\u6027\u3092\u4ea2\u9032\u3059\u308b\u304c\u3001FXII\u963b\u5bb3\u306f\u751f\u7406\u7684\u306a\u6b62\u8840\u306b\u306f\u5f71\u97ff\u3057\u306a\u3044\u3053\u3068\u304b\u3089\u3001FXII\u963b\u5bb3\u5264\u306f\u6297\u8840\u6813\u85ac\u3068\u3057\u3066\u671f\u5f85\u3055\u308c\u3066\u3044\u308b\u3002\u6211\u3005\u306fFXII\u306e\u7cd6\u9396\u4fee\u98fe(<em>O-<\/em>Fuc\u3001<em>N-<\/em>\u7d50\u5408\u578b\u7cd6\u9396\u3001<em>O-<\/em>\u7d50\u5408\u578b\u7cd6\u9396)\u306b\u7740\u76ee\u3057\u3001FXII\u306e\u6d3b\u6027\u80fd\u3068\u306e\u95a2\u308f\u308a\u3084\u3001\u6d3b\u6027\u5316\u5236\u5fa1\u306e\u53ef\u80fd\u6027\u3092\u8ffd\u6c42\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<h2 class=\"r_title\" style=\"text-align: left\">\u00a0HepG2\u7d30\u80de\u306b\u898b\u51fa\u3057\u305f\u8840\u6db2\u51dd\u56faXII\u56e0\u5b50\u77ed\u9396\u30a2\u30a4\u30bd\u30d5\u30a9\u30fc\u30e0\u306e\u7279\u5b9a<\/h2>\n<p>\u7d30\u80de\u306b\u304a\u3051\u308b\u8840\u6db2\u51dd\u56faXII\u56e0\u5b50\u306e\u7cd6\u9396\u4fee\u98fe\u904e\u7a0b\u3092\u8abf\u3079\u308b\u76ee\u7684\u3067\u30d2\u30c8\u809d\u81d3\u304c\u3093\u7531\u6765\u7d30\u80deHepG2\u306e\u4e8c\u7a2e\u306e\u4e9c\u682a\u304b\u3089FXII\u3092\u691c\u51fa\u3057\u305f\u3068\u3053\u308d\u3001\u8208\u5473\u6df1\u3044\u3053\u3068\u306b\u7247\u65b9\u306e\u7d30\u80de\u682a\u304b\u3089\u306f\u77ed\u9396\u306eFXII\u304c\u4e3b\u8981\u306a\u5206\u5b50\u7a2e\u3068\u3057\u3066\u7523\u751f\u3055\u308c\u3066\u3044\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002\u3053\u306e\u77ed\u9396FXII\u306e\u7279\u5b9a\u3092\u9032\u3081\u3001\u751f\u7406\u7684\u30fb\u75c5\u7406\u7684\u610f\u7fa9\u306e\u89e3\u660e\u3092\u9032\u3081\u3066\u3044\u307e\u3059\u3002<\/p>\n<h2 class=\"r_title\" style=\"text-align: left\">\u00a0\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u306b\u3088\u308b\u553e\u6db2\u817a\u7d30\u80de\u306e\u7cd6\u9396\u4fee\u98fe\u306e\u5909\u5316\u3068\u7d30\u80de\u6a5f\u80fd\u3068\u306e\u95a2\u308f\u308a<\/h2>\n<p>\u767a\u75c7\u7387\u306b\u7537\u5973\u5dee\u304c\u3042\u308b\u3001\u3042\u308b\u3044\u306f\u767a\u75c7\u7387\u304c\u540c\u7a0b\u5ea6\u3067\u3082\u75c5\u614b\u306e\u7d4c\u904e\u306b\u7537\u5973\u3067\u9055\u3044\u304c\u898b\u3089\u308c\u308b\u75be\u60a3\u306b\u3064\u3044\u3066\u3001\u5185\u5206\u6ccc\u74b0\u5883\u306e\u5909\u52d5\u306b\u7740\u76ee\u3057\u305f\u767a\u75c7\u6a5f\u69cb\u306e\u89e3\u660e\u306f\u3001\u3088\u308a\u9069\u5207\u3067\u6709\u52b9\u306a\u6cbb\u7642\u63d0\u6848\u3084\u3001\u500b\u5225\u5316\u533b\u7642\u30fb\u7cbe\u5bc6\u533b\u7642\u306e\u5b9f\u73fe\u306b\u3064\u306a\u304c\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u3001\u793e\u4f1a\u7684\u8981\u8acb\u306e\u9ad8\u3044\u7814\u7a76\u8ab2\u984c\u3068\u8a00\u3048\u307e\u3059\u3002\u5973\u6027\u306e\u30e9\u30a4\u30d5\u30b5\u30a4\u30af\u30eb\u306b\u304a\u3044\u3066\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u306e\u4f4e\u4e0b\u304c\u8d77\u3053\u308b\u5e74\u9f62\u4ee5\u964d\u306b\u767a\u75c7\u3059\u308b\u3053\u3068\u304c\u591a\u3044\u53e3\u8154\u4e7e\u71e5\u75c7\u306a\u3069\u306e\u75be\u60a3\u3067\u306f\u3001\u553e\u6db2\u306e\u5206\u6ccc\u4e0d\u5168\u3084\u553e\u6db2\u817a\u7d30\u80de\u306e\u640d\u50b7\u304c\u539f\u56e0\u3068\u306a\u308b\u3053\u3068\u304b\u3089\u3001\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u6fc3\u5ea6\u4f4e\u4e0b\u2192\u553e\u6db2\u817a\u7d30\u80de\u306e\u7cd6\u9396\u4fee\u98fe\u5909\u5316\u2192\u7d30\u80de\u6a5f\u80fd\u5909\u5316\u3092\u4f5c\u696d\u4eee\u8aac\u3068\u3057\u3066\u691c\u8a3c\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n<h2 class=\"r_title\" style=\"text-align: left\">\u9d8f\u5375\u306e\u5375\u9ec4\u819c\u306b\u5c40\u5728\u3059\u308bVMO1\u306e\u751f\u7406\u6d3b\u6027\u306e\u63a2\u7d22<\/h2>\n<p>Vitelline membrane outer layer protein 1 \u306f\u9d8f\u5375\u306e\u5375\u9ec4\u819c\u306b\u542b\u307e\u308c\u308b\u7cd6\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3001\u03b2-\u30d7\u30ea\u30ba\u30e0\u30d5\u30a9\u30fc\u30eb\u30c9\u30ec\u30af\u30c1\u30f3\u3068\u7acb\u4f53\u69cb\u9020\u985e\u4f3c\u6027\u304c\u3042\u308a\u307e\u3059\u3002VMO1\u306e\u751f\u7406\u6d3b\u6027\u3084\u7269\u6027\u3092\u660e\u3089\u304b\u306b\u3057\u3001\u9d8f\u5375\u5f62\u6210\u3084\u9d8f\u5375\u5185\u3067\u306e\u767a\u80b2\u904e\u7a0b\u306b\u304a\u3051\u308b\u751f\u7269\u5b66\u7684\u5f79\u5272\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u3053\u3068\u304c\u76ee\u6a19\u3067\u3059\u3002<\/p>\n<h2 class=\"r_title\" style=\"text-align: left\">\u30a2\u30cd\u30ad\u30b7\u30f3\u30d5\u30a1\u30df\u30ea\u30fc\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u6a5f\u80fd\u306b\u95a2\u3059\u308b\u7814\u7a76<\/h2>\n<p class=\"r_title\" style=\"text-align: left\">\u3000\u201c\u30a2\u30cd\u30ad\u30b7\u30f3\u201d\u306f\u30ab\u30eb\u30b7\u30a6\u30e0\u7d50\u5408\u30bf\u30f3\u30d1\u30af\u8cea\u30d5\u30a1\u30df\u30ea\u30fc\u3067\u3001\u30d2\u30c8\u30b2\u30ce\u30e0\u306b\u306f12\u7a2e\u985e\u306e\u30a2\u30cd\u30ad\u30b7\u30f3\u907a\u4f1d\u5b50\u304c\u898b\u3064\u304b\u3063\u3066\u3044\u307e\u3059\u3002\u56f31\u306b\u30a2\u30cd\u30ad\u30b7\u30f3\u306e\u69cb\u9020\u306e\u7279\u5fb4\u3092\u3001\u56f32\u306b\u30d2\u30c8ANXA1\u306e\u30b3\u30a2\u30c9\u30e1\u30a4\u30f3\u306e\u7acb\u4f53\u69cb\u9020\u3092\u793a\u3057\u307e\u3057\u305f\u3002<\/p>\n<p><a href=\"https:\/\/www-p.sci.ocha.ac.jp\/chem-aikawa-lab\/wp-content\/uploads\/sites\/8\/2015\/08\/res2014_fig1.png\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-169 alignnone\" src=\"https:\/\/www-p.sci.ocha.ac.jp\/chem-aikawa-lab\/wp-content\/uploads\/sites\/8\/2015\/08\/res2014_fig1.png\" alt=\"res2014_fig1\" width=\"882\" height=\"222\" srcset=\"https:\/\/www-p.sci.ocha.ac.jp\/chem-aikawa-lab\/wp-content\/uploads\/sites\/8\/2015\/08\/res2014_fig1.png 882w, https:\/\/www-p.sci.ocha.ac.jp\/chem-aikawa-lab\/wp-content\/uploads\/sites\/8\/2015\/08\/res2014_fig1-300x76.png 300w\" sizes=\"auto, (max-width: 882px) 100vw, 882px\" \/><\/a><\/p>\n<p class=\"r_title\" style=\"text-align: left\"><a href=\"https:\/\/www-p.sci.ocha.ac.jp\/chem-aikawa-lab\/wp-content\/uploads\/sites\/8\/2015\/08\/res2014_fig2.png\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-170 alignnone\" src=\"https:\/\/www-p.sci.ocha.ac.jp\/chem-aikawa-lab\/wp-content\/uploads\/sites\/8\/2015\/08\/res2014_fig2.png\" alt=\"res2014_fig2\" width=\"810\" height=\"306\" srcset=\"https:\/\/www-p.sci.ocha.ac.jp\/chem-aikawa-lab\/wp-content\/uploads\/sites\/8\/2015\/08\/res2014_fig2.png 810w, https:\/\/www-p.sci.ocha.ac.jp\/chem-aikawa-lab\/wp-content\/uploads\/sites\/8\/2015\/08\/res2014_fig2-300x113.png 300w\" sizes=\"auto, (max-width: 810px) 100vw, 810px\" \/><\/a><\/p>\n<p>\u3000\u30a2\u30cd\u30ad\u30b7\u30f3\u306f\u59cb\u3081\u306b\u30ab\u30eb\u30b7\u30a6\u30e0\u30a4\u30aa\u30f3\u4f9d\u5b58\u7684\u306b\u7d30\u80de\u819c\u3084\u9178\u6027\u30ea\u30f3\u8102\u8cea\u30db\u30b9\u30d5\u30a1\u30c1\u30b8\u30eb\u30bb\u30ea\u30f3\u306b\u7d50\u5408\u6027\u3092\u6301\u3064\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u3057\u3066\u767a\u898b\u3055\u308c\u307e\u3057\u305f\u3002\u4e00\u65b9\u3001\u79c1\u305f\u3061\u306f \u8ca0\u96fb\u8377\u3092\u6301\u3064\u7cd6\u9396\u3067\u3042\u308b\u30b7\u30a2\u30ea\u30eb\u30aa\u30ea\u30b4\u7cd6\u3084\u30d8\u30d1\u30ea\u30f3\u306b\u7d50\u5408\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u63a2\u7d22\u3059\u308b\u7814\u7a76\u306e\u904e\u7a0b\u3067\u3001\u30a6\u30b7\u814e\u81d3\u304b\u3089p33\/41\u3092\u898b\u3044\u3060\u3057\u307e\u3057\u305f [Kojima, K <i>et al., J Chromatogr<\/i> 597(1992)323-330.]\u3002\u69cb\u9020\u89e3\u6790\u3068\u907a\u4f1d\u5b50\u30af\u30ed\u30fc\u30cb\u30f3\u30b0\u306e\u7d50\u679c\u3001p33\/41\u306f\u30a2\u30cd\u30ad\u30b7\u30f3A4(ANXA4)\u3068\u540c\u4e00\u3067\u3042\u308b\u3053\u3068\u304c\u308f\u304b\u308a[Kojima, K. <i>et al., J Biol Chem<\/i> 267(1992)20536-20539., Kojima, K. <i>et al., J Biol Chem<\/i> 271(1996)7679-7685.]\u3001\u305d\u306e\u5f8c\u3001ANXA5\u3068ANXA6\u3082\u30b0\u30ea\u30b3\u30b5\u30df\u30ce\u30b0\u30ea\u30ab\u30f3\u306b\u7d50\u5408\u6027\u304c\u3042\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f[Ishitsuka, R. <i>et al., J Biol Chem<\/i> 273(1998)9935-9941.]\u3002\u30b0\u30ea\u30b3\u30b5\u30df\u30ce\u30b0\u30ea\u30ab\u30f3\u3078\u306e\u7d50\u5408\u6d3b\u6027\u306f\u3001\u30a2\u30ab\u30d1\u30f3\u30ab\u30d3\u3084\u3001\u7dda\u866b <i>C. elegans<\/i>\u306e\u30a2\u30cd\u30ad\u30b7\u30f3\u306b\u3082\u3042\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057[Nishioka, S. <i>et al., J Biochem<\/i> 141(2007)837-848.]\u3001\u69d8\u3005\u306a\u751f\u7269\u7a2e\u306b\u767a\u73fe\u3055\u308c\u3066\u3044\u308b\u30a2\u30cd\u30ad\u30b7\u30f3\u304c\u5171\u901a\u306b\u6301\u3063\u3066\u3044\u308b\u6d3b\u6027\u3067\u3042\u308b\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002<br \/>\n\u30a2\u30cd\u30ad\u30b7\u30f3\u30d5\u30a1\u30df\u30ea\u30fc\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u591a\u7d30\u80de\u751f\u7269\u306b\u5e83\u304f\u767a\u73fe\u3055\u308c\u3066\u304a\u308a\u3001\u30d2\u30c8\u3067\u306f\u8d64\u8840\u7403\u3092\u9664\u304f\u3059\u3079\u3066\u306e\u7d30\u80de\u306b\u3001\u4e00\u3064\u4ee5\u4e0a\u306e\u30a2\u30cd\u30ad\u30b7\u30f3\u304c\u767a\u73fe\u3055\u308c\u3066\u3044\u308b\u3068\u8003 \u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u30a2\u30cd\u30ad\u30b7\u30f3\u306f\u30d8\u30d1\u30ea\u30f3\/\u30d8\u30d1\u30e9\u30f3\u786b\u9178\u3001\u30dd\u30ea\u30ea\u30f3\u9178\u306a\u3069\u306e\u8ca0\u96fb\u8377\u6027\u306e\u751f\u4f53\u5206\u5b50\u3068\u76f8\u4e92\u4f5c\u7528\u3059\u308b\u3053\u3068\u304b\u3089\u3001\u30a2\u30cd\u30ad\u30b7\u30f3\u306f\u3053\u308c\u3089\u306e\u8ca0\u96fb\u8377\u6027\u5206\u5b50\u304c \u6d3b\u6027\u5316\u3059\u308b\u751f\u4f53\u5185\u53cd\u5fdc\u3084\u8907\u5408\u4f53\u5f62\u6210\u306e\u30ec\u30ae\u30e5\u30ec\u30fc\u30bf\u30fc\u3068\u3057\u3066\u50cd\u3044\u3066\u3044\u308b\u3068\u8003\u3048\u3001\u305d\u306e\u6a5f\u69cb\u89e3\u660e\u3092\u76ee\u7684\u306b\u7814\u7a76\u3092\u9032\u3081\u3066\u3044\u307e\u3059\u3002<\/p>\n<h3 class=\"r_title\" style=\"text-align: left\">\u30c6\u30fc\u30de1:\u6297\u51dd\u56fa\/\u6297\u8840\u6813\u30bf\u30f3\u30d1\u30af\u8cea ANXA4\u3068ANXA5\u306e\u6d3b\u6027\u767a\u73fe\u6a5f\u69cb<\/h3>\n<p class=\"aligncenter size-full wp-image-171\">\u3000\u8840\u6db2\u51dd\u56fa\u7cfb\u3084\u8840\u6813\u5f62\u6210\u306e\u4ea2\u9032\u306f\u3001\u65e5\u672c\u306e\u4e09\u5927\u6b7b\u56e0\u3067\u3042\u308b\u75be\u60a3-\u5fc3\u7b4b\u6897\u585e\u3001\u8133\u6897\u585e\u3001\u304c\u3093-\u3068\u76f4\u63a5\u7684\u30fb\u9593\u63a5\u7684\u306b\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002\u8840\u6db2\u306e\u6d41\u52d5\u6027\u306e\u7dad\u6301\u306f\u9178\u7d20\u3084\u6804 \u990a\u6210\u5206\u306e\u4f53\u5185\u904b\u642c\u306e\u305f\u3081\u306b\u5fc5\u9808\u3067\u3042\u308a\u3001\u672c\u6765\u53b3\u5bc6\u306b\u5236\u5fa1\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u8840\u6db2\u51dd\u56fa\u53cd\u5fdc\u306f\u51fa\u8840\u306b\u3088\u308a\u4f53\u5185\u304b\u3089\u8840\u6db2\u304c\u5931\u308f\u308c\u308b\u3053\u3068\u3092\u9632\u304e\u3001\u307e\u305f\u4f53\u5185\u3067\u75c5\u539f\u83cc \u304c\u5897\u6b96\u30fb\u64ad\u7a2e\u3059\u308b\u4e8b\u3092\u963b\u6b62\u3059\u308b\u751f\u7406\u7684\u306a\u751f\u4f53\u9632\u5fa1\u53cd\u5fdc\u3067\u3059\u3002\u3057\u304b\u3057\u3001\u8840\u7ba1\u58c1\u306e\u6027\u72b6\u306e\u5909\u5316\u3001\u8840\u6db2\u6210\u5206\u306e\u5909\u5316\u3001\u8840\u6d41\u306e\u5909\u5316\u306a\u3069\u3067\u305d\u306e\u8abf\u7bc0\u6a5f\u69cb\u304c\u3046\u307e\u304f\u50cd\u304b\u306a\u304f\u306a \u308b\u3068\u8840\u6813\u50be\u5411\u304c\u4ea2\u9032\u3057\u307e\u3059\u3002ANXA5\u3068ANXA4\u306f<i>in vitro<\/i>\u3067\u5f37\u3044\u6297\u51dd\u56fa\u6d3b\u6027\u304c\u3042\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3057\u305f\u3002\u79c1\u305f\u3061\u306fANXA4\u306e\u6297\u51dd\u56fa\u6d3b\u6027\u306e\u767a\u73fe\u6a5f\u69cb\u306e\u4e00\u3064\u304c\u3001\u8840\u6db2\u51dd\u56faXII\u56e0\u5b50\u306e\u63a5\u89e6\u6d3b\u6027\u5316\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f(Nakayama M, <em>et al. <\/em>2020. DOI:10.1111\/jth.14789)\u3002<\/p>\n<p style=\"text-align: left\">\n","protected":false},"excerpt":{"rendered":"<p>\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u6d3b\u6027\u767a\u73fe\u3084\u69cb\u9020\u7279\u6027\u306b\u304a\u3051\u308b\u7cd6\u9396\u4fee\u98fe\u306e\u5f79\u5272\u3092\u3001\u751f\u5316\u5b66\u3001\u7d30\u80de\u751f\u7269\u5b66\u3001\u907a\u4f1d\u5b50\u5de5\u5b66\u306e\u624b\u6cd5\u3092\u4f7f\u3063\u3066\u8abf\u3079\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u30ec\u30af\u30c1\u30f3\u306e\u751f\u7269\u5b66\u7684\u5f79\u5272\u306e\u89e3\u660e\u3068\u305d\u306e\u5fdc\u7528\u3082\u7814\u7a76\u5bfe\u8c61\u3068\u3057\u3066\u3044\u307e\u3059\u3002\u4ee5\u4e0b\u304c\u73fe\u5728\u9032\u3081\u3066\u3044\u308b\u7814\u7a76\u30c6\u30fc\u30de\u3068\u305d\u306e\u6982 &hellip; <a href=\"https:\/\/www-p.sci.ocha.ac.jp\/chem-aikawa-lab\/research.html\">\u7d9a\u304d\u3092\u8aad\u3080 <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":17,"featured_media":0,"parent":0,"menu_order":5,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-43","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www-p.sci.ocha.ac.jp\/chem-aikawa-lab\/wp-json\/wp\/v2\/pages\/43","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www-p.sci.ocha.ac.jp\/chem-aikawa-lab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www-p.sci.ocha.ac.jp\/chem-aikawa-lab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www-p.sci.ocha.ac.jp\/chem-aikawa-lab\/wp-json\/wp\/v2\/users\/17"}],"replies":[{"embeddable":true,"href":"https:\/\/www-p.sci.ocha.ac.jp\/chem-aikawa-lab\/wp-json\/wp\/v2\/comments?post=43"}],"version-history":[{"count":9,"href":"https:\/\/www-p.sci.ocha.ac.jp\/chem-aikawa-lab\/wp-json\/wp\/v2\/pages\/43\/revisions"}],"predecessor-version":[{"id":949,"href":"https:\/\/www-p.sci.ocha.ac.jp\/chem-aikawa-lab\/wp-json\/wp\/v2\/pages\/43\/revisions\/949"}],"wp:attachment":[{"href":"https:\/\/www-p.sci.ocha.ac.jp\/chem-aikawa-lab\/wp-json\/wp\/v2\/media?parent=43"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}