{"id":106,"date":"2018-04-06T17:10:43","date_gmt":"2018-04-06T08:10:43","guid":{"rendered":"http:\/\/www-p.sci.ocha.ac.jp\/bio-monai-lab\/?page_id=106"},"modified":"2023-09-14T15:02:49","modified_gmt":"2023-09-14T06:02:49","slug":"research","status":"publish","type":"page","link":"https:\/\/www-p.sci.ocha.ac.jp\/bio-monai-lab\/research.html","title":{"rendered":"\u7814\u7a76\u5185\u5bb9"},"content":{"rendered":"

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  1. \u306f\u3058\u3081\u306b<\/a><\/span><\/li>\n
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  4. \u7814\u7a76\u30c6\u30fc\u30de\u306e\u4f8b<\/a><\/span><\/li>\n
  5. News and Media<\/span><\/a><\/li>\n
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    \u751f\u4f53\u8133\u6df1\u90e8\u89b3\u6e2c\u3068\u8133\u7d44\u7e54\u306e\u751f\u7269\u7269\u7406\u5b66\u7279\u6027\u306e\u89e3\u660e<\/a><\/span><\/div>\n<\/li>\n<\/ol>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

    <\/a>\u306f\u3058\u3081\u306b<\/span><\/h1>\n

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    <\/a>\u53c2\u8003\u30fb\u63a8\u85a6\u56f3\u66f8 <\/span><\/h1>\n
      \n
    1. \u6bdb\u5185\u62e1 \u8457 \u8133\u3092\u53f8\u308b\u300c\u8133\u300d <\/span>\u8b1b\u8ac7\u793e <\/span><\/li>\n
    2. \u5de5\u85e4\u4f73\u4e45 \u8457\u00a0 \u6539\u8a02\u7248\u3082\u3063\u3068\u3088\u304f\u308f\u304b\u308b\uff01\u8133\u795e\u7d4c\u79d1\u5b66\u301c\u3084\u3063\u3071\u308a\u8133\u306f\u3068\u3063\u3066\u3082\u3059\u3054\u3044\u306e\u3060\u301c \u7f8a\u571f\u793e <\/span><\/li>\n
    3. \u5bae\u5ddd\u535a\u7fa9\u30fb\u4e95\u4e0a\u96c5\u53f8 \u8457\u300c\u30cb\u30e5\u30fc\u30ed\u30f3\u306e\u751f\u7269\u7269\u7406 \u7b2c2\u7248\u300d\u4e38\u5584\u51fa\u7248<\/span><\/li>\n<\/ol>\n

      <\/a>\u4ee3\u8868\u7684\u306a\u8ad6\u6587<\/span><\/h1>\n
        \n
      1. H. Monai<\/span>, S. Koketsu, Y. Shinohara, T. Ueki, P. Kusk, NL. Hauglund, AJ. Samson, M. Nedergaard & H. Hirase, Adrenergic inhibition facilitates normalization of extracellular potassium after cortical spreading depolarization, Sci Rep 11, 8150 (2021). https:\/\/doi.org\/10.1038\/s41598-021-87609-w<\/a><\/span><\/li>\n
      2. H. Monai, X. Wang, K. Yahagi, N. Lou, H. Mestre, Q. Xu, Y. Abe, M. Yasui, Y. Iwai, M. Nedergaard, H. Hirase, Adrenergic receptor antagonism induces neuroprotection and facilitates recovery from acute ischemic stroke,\u00a0Proceedings of the National Academy of Sciences<\/a>,\u00a0May 28, 2019,\u00a0<\/span>116\u00a0<\/span>(22)\u00a0<\/span>11010-11019<\/span>, DOI:\u00a010.1073\/pnas.1817347116<\/a><\/span><\/li>\n
      3. Y. Ue*,\u00a0H. Monai<\/span>*, K. Higuchi, D. Nishiwaki, T. Tajima, K. Okazaki, H. Hama, H. Hirase, A. Miyawaki, A spherical aberration-free microscopy system for live brain imaging,\u00a0Biochem Biophys Res Commun<\/a>, Volume 500, Issue 2, 2 June 2018, Pages 236-241. DOI:\u00a010.1016\/j.bbrc.2018.04.049<\/a><\/span>
        \n*These authors contributed equally to this work.<\/span><\/li>\n
      4. H. Monai<\/span>, M. Ohkura, M. Tanaka, Y. Oe, A. Konno, K. Hirai, K. Mikoshiba, S. Itohara, J. Nakai, Y. Iwai, H. Hirase, Calcium imaging reveals glial involvement in transcranial direct current stimulation-induced plasticity in mouse brain., Nature communications<\/a>, Mar 2016;7:11100<\/span><\/li>\n
      5. H. Monai<\/span>, M. Inoue, H. Miyakawa, T. Aonishi, Low-frequency dielectric dispersion of brain tissue due to electrically long neurites. Physical Review E<\/a>, Dec 2012;86(6-1):061911. <\/span><\/li>\n<\/ol>\n

        <\/a>\u2606\u5352\u8ad6\u30fb\u4fee\u8ad6 \u7814\u7a76\u30c6\u30fc\u30de\u306e\u4f8b<\/span><\/h1>\n\n\n<\/colgroup>\n\n\n\n\n\n\n\n\n\n\n\n\n
        \u8133\u6897\u585e\u8d85\u6025\u6027\u671f\u306b\u304a\u3051\u308b\u8133\u306e\u6c34\u30c1\u30e3\u30cd\u30eb\u5206\u5b50\u30a2\u30af\u30a2\u30dd\u30ea\u30f3 4 \u975e\u5c40\u5728\u5316\u306e\u8a55\u4fa1\u6cd5\u306e\u78ba\u7acb<\/span><\/td>\n<\/tr>\n
        \u8133\u7d44\u7e54\u306e\u5149\u5b66\u7279\u6027\u3092\u5229\u7528\u3057\u305f\u6c34\u7d44\u6210\u5909\u6027\u306e\u8a55\u4fa1<\/span><\/td>\n<\/tr>\n
        \u7d4c\u982d\u84cb\u76f4\u6d41\u96fb\u6c17\u523a\u6fc0\u304c\u8133\u810a\u9ac4\u6db2\u3068\u9593\u8cea\u6db2\u306e\u4ea4\u63db\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u306e\u89e3\u6790<\/span><\/td>\n<\/tr>\n
        \u6162\u6027\u7684\u306a\u8efd\u5ea6\u306e\u30b9\u30c8\u30ec\u30b9\u304b\u3089\u306e\u56de\u5fa9\u306b\u304a\u3051\u308b<\/span>\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8IP3\/Ca2+\u30b7\u30b0\u30ca\u30eb\u306e\u5bc4\u4e0e\u306e\u89e3\u660e<\/span><\/td>\n<\/tr>\n
        \u30ac\u30f3\u30de\u5468\u6ce2\u6570\u306e\u5149\u3084\u97f3\u523a\u6fc0\u304c\u795e\u7d4c\u30b0\u30ea\u30a2\u56de\u8def\u7db2\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u306e\u751f\u7406\u5b66\u7684\u89e3\u6790<\/span><\/td>\n<\/tr>\n
        AAV\u767a\u73fe\u7cfb\u306b\u3088\u308bTDP-43\u767a\u73fe\u30de\u30a6\u30b9\u306e\u4f5c\u88fd<\/span><\/td>\n<\/tr>\n
        \u30d2\u30c8\u7279\u7570\u7684\u03b11\u30a2\u30c9\u30ec\u30ca\u30ea\u30f3\u53d7\u5bb9\u4f53\u3092\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u306b\u767a\u73fe\u3057\u305f\u30de\u30a6\u30b9\u306e\u8133\u6a5f\u80fd\u89e3\u6790<\/span><\/td>\n<\/tr>\n
        \u30de\u30a6\u30b9\u306b\u304a\u3051\u308b\u526f\u4ea4\u611f\u795e\u7d4c\u306e\u306f\u305f\u3089\u304d\u306e\u53ef\u8996\u5316<\/span><\/td>\n<\/tr>\n
        \u771f\u6b63\u7c98\u83cc\u539f\u5f62\u8cea\u306e\u7ba1\u5f62\u6210\u30fb\u9078\u629e\u306e\u30e1\u30ab\u30cb\u30ba\u30e0<\/span><\/td>\n<\/tr>\n
        \u565b\u307f\u3057\u3081\u7fd2\u6163\u306b\u3088\u308b\u5b66\u7fd2(\u8a8d\u77e5\u6a5f\u80fd)\u52b9\u679c\u3092\u8abf\u3079\u308b<\/span><\/td>\n<\/tr>\n
        \u8178\u304b\u3089\u306e\u6804\u990a\u5438\u53ce\u5f8c\u306e\u8ff7\u8d70\u795e\u7d4c\u6d3b\u6027\u5316\u60f9\u8d77\u6027\u306e\u5831\u916c\u5fdc\u7b54\u306e\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u3001\u53ca\u3073\u30b9\u30c8\u30ec\u30b9\u5f8c\u306e\u5909\u5316\u306e\u89b3\u5bdf<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

         <\/p>\n

        <\/a>News & Media<\/span><\/h1>\n

        \"\"\u79c1\u305f\u3061\u306e\u8ad6\u6587\u304c2019\u5e745\u670828\u65e5\u53f7\u306ePNAS\u8a8c\u5dfb\u982d\u306e\u4eca\u9031\u306e\u6ce8\u76ee\u8ad6\u6587 “This Week in PNAS<\/a>”\u00a0\u306e\u4e00\u3064\u306b\u9078\u51fa\u3055\u308c\u307e\u3057\u305f\u3002”Adrenergic receptor antagonism may reduce stroke damage”<\/span><\/p>\n

         <\/p>\n

        \"\"2019\u5e745\u670820\u65e5\u00a0\u7814\u7a76\u7d50\u679c\u304c \u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9<\/a>\u3055\u308c\u307e\u3057\u305f\u3002\u4eca\u56de\u79c1\u305f\u3061\u306f\u3001\u8133\u6897\u585e \u306e\u8d85\u6025\u6027\u671f\u306b \u30a2\u30c9\u30ec\u30ca\u30ea\u30f3\u53d7\u5bb9\u4f53 \u3092\u963b\u5bb3\u3059\u308b\u3068\u3001\u8133\u640d\u50b7\u304c\u6700\u5c0f\u9650\u306b\u98df\u3044\u6b62\u3081\u3089\u308c\u308b\u3053\u3068\u3092\u767a\u898b\u3057\u307e\u3057\u305f\u3002\u8133\u810a\u9ac4\u6db2 \u306e \u30af\u30ea\u30a2\u30e9\u30f3\u30b9\u6a5f\u69cb \u306b\u3088\u3063\u3066\u7d30\u80de\u5916\u30ab\u30ea\u30a6\u30e0\u30a4\u30aa\u30f3\u6fc3\u5ea6\u306e\u6b63\u5e38\u5316\u304c\u4fc3\u9032\u3055\u308c\u305f\u7d50\u679c\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/span><\/p>\n

        \"\"<\/p>\n

        2018\u5e745\u67087\u65e5 \u30aa\u30ea\u30f3\u30d1\u30b9\u3068\u5171\u540c\u958b\u767a\u3057\u305f\u9855\u5fae\u93e1\u30b7\u30b9\u30c6\u30e0<\/a>\u306b\u95a2\u3059\u308b\u7814\u7a76\u6210\u679c<\/a>\u304c\u5831\u9053\u767a\u8868<\/a>\u3055\u308c\u307e\u3057\u305f\u3002<\/span><\/p>\n

         <\/p>\n

         <\/p>\n

        <\/span><\/p>\n

        G7NG817\u907a\u4f1d\u5b50\u6539\u5909\u30de\u30a6\u30b9\u306b\u3088\u308b\u751f\u4f53\u8133Ca2+<\/sup>\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0<\/span><\/h2>\n

        \u3000\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u3068\u4e00\u90e8\u306e\u30cb\u30e5\u30fc\u30ed\u30f3\u306bCa2+<\/sup>\u30bb\u30f3\u30b5\u30fc\u30bf\u30f3\u30d1\u30af\u8ceaG-CaMP7\u3092\u767a\u73fe\u3057\u305f\u907a\u4f1d\u5b50\u6539\u5909\u30de\u30a6\u30b9(G7NG817\u30de\u30a6\u30b9)\u3092\u7528\u3044\u305f\u751f\u4f53\u8133Ca2+<\/sup>\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u3092\u4e3b\u5e79\u3068\u3057\u305f\u7814\u7a76\u3092\u884c\u3044\u307e\u3059\u3002<\/span><\/p>\n

        \"\"<\/span><\/p>\n

        \u30de\u30a6\u30b9\u56fa\u5b9a\u8133\u306b\u304a\u3051\u308b\u86cd\u5149\u306e\u767a\u73fe\u30d1\u30bf\u30fc\u30f3 \u306e\u77e2\u72b6\u9762(\u5de6\u53f3\u306b\u5206\u3051\u308b\u9762)\u306e\u65ad\u9762\u56f3<\/span>
        \n\u4e0a: \u6bd4\u8f03\u7528\u306e\u91ce\u751f\u578b(C57BL\/6)\u30de\u30a6\u30b9\u8133\u3002<\/span>
        \n\u4e0b: \u4f5c\u88fd\u3057\u305f G7NG817 \u30de\u30a6\u30b9\u8133\u3002\u5927\u8133\u76ae\u8cea\u3068\u6d77\u99ac\u306e\u4e00\u90e8\u306b\u8457\u3057\u3044 G-CaMP7 \u306e\u767a\u73fe\u304c\u307f\u3089\u308c\u308b\u3002\u3053\u306e\u5f37\u3044\u767a\u73fe\u306e\u305f\u3081\u306b\u3001\u86cd\u5149\u5909\u5316\u3092\u982d\u84cb\u9aa8\u8d8a\u3057\u306b\u6e2c\u5b9a\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3002<\/span><\/p>\n

        G7NG817\u30de\u30a6\u30b9\u306f\u3001\u5927\u8133\u76ae\u8cea\u306b\u304a\u3051\u308b\u86cd\u5149\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u767a\u73fe\u304c\u9ad8\u3044\u305f\u3081\u3001\u5b9f\u4f53\u86cd\u5149\u9855\u5fae\u93e1\u4e0b\u3067\u3001\u9aa8\u3092\u524a\u308b\u3053\u3068\u306a\u304f\u982d\u84cb\u9aa8\u8d8a\u3057\u306bCa2+<\/sup>\u52d5\u614b\u3092\u8a08\u6e2c\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/span>
        \n \u4f8b\u3048\u3070\u3001\u30a6\u30ec\u30bf\u30f3\u9ebb\u9154\u4e0b\u3084\u5f90\u6ce2\u7761\u7720\u6642\u306b\u898b\u3089\u308c\u308b\u7279\u5fb4\u7684\u306a\u4f4e\u5468\u6ce2\u30fb\u9ad8\u632f\u5e45\u306e\u8133\u6ce2\u306b\u5bfe\u5fdc\u3059\u308bCa2+<\/sup>\u632f\u52d5\u3092\u8a08\u6e2c\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059 (\u4e0b\u56f3)\u3002<\/span><\/p>\n

        \"\"<\/span><\/p>\n

        \u30a6\u30ec\u30bf\u30f3\u9ebb\u9154\u4e0b\u306eG7NG817\u30de\u30a6\u30b9\u306b\u304a\u3051\u308b\u5f90\u6ce2\u306b\u5bfe\u5fdc\u3059\u308bCa2+<\/sup>\u86cd\u5149\u8f1d\u5ea6\u5909\u5316\u306e\u7d4c\u982d\u84cb\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0<\/span>
        \n(A). \u9ebb\u9154\u4e0b\u306eG7NG817\u30de\u30a6\u30b9\u3067\u306f\u3001\u9ad8\u632f\u5e45\u30fb\u4f4e\u5468\u6ce2\u6570\u3067\u7279\u5fb4\u4ed8\u3051\u3089\u308c\u308b\u81ea\u767a\u7684\u306aCa2+<\/sup>\u632f\u52d5\u304c\u5168\u76ae\u8cea\u306b\u6e21\u3063\u3066\u3001\u5de6\u53f3\u8133\u3067\u540c\u671f\u3057\u3066\u89b3\u6e2c\u3055\u308c\u308b\u3002\u305d\u306e\u86cd\u5149\u8f1d\u5ea6\u5909\u5316\u7387 (\u0394F\/F)\u3092\u7591\u4f3c\u30ab\u30e9\u30fc\u3067\u8868\u793a\u3057\u305f\u3002<\/span>
        \n(B). A\u3067\u53f3\u8133\u8996\u899a\u91ce (\u56db\u89d2\u3067\u56f2\u3063\u305f\u90e8\u4f4d) \u306b\u304a\u3051\u308b\u5e73\u5747\u8f1d\u5ea6\u5909\u5316\u7387 (\u0394F\/F)\u3092\u30d7\u30ed\u30c3\u30c8\u3057\u305f\u56f3\u3002Ca2+<\/sup>\u6fc3\u5ea6\u632f\u52d5\u306e\u5468\u6ce2\u6570\u306f0.5 \u304b\u3089 2 Hz\u7a0b\u5ea6\u3067\u3001\u8133\u6ce2\u8a18\u9332\u3067\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u5f90\u6ce2\u632f\u52d5\u3068\u540c\u69d8\u306e\u5024\u3067\u3042\u308b\u3002\u8a18\u9332\u306f10 Hz\u306e\u30d5\u30ec\u30fc\u30e0\u30ec\u30fc\u30c8\u3067\u884c\u306a\u3063\u305f\u3002<\/span>
        \n(C). B\u3067\u70b9\u7dda\u3067\u56f2\u3063\u305f\u90e8\u4f4d\u3092\u62e1\u5927\u3057\u305f\u56f3\u3002\u3072\u3057\u5f62\u3067\u793a\u3057\u305f\u70b9\u306b\u5bfe\u5fdc\u3059\u308b\u753b\u50cf\u3092A\u306b\u793a\u3057\u305f\u3002<\/span><\/p>\n

        \u4e00\u65b9\u3001\u30c6\u30fc\u30eb\u30d4\u30f3\u30c1\u523a\u6fc0\u306b\u3088\u3063\u3066\u306f\u3001\u8133\u6ce2\u540c\u69d8\u3001\u901f\u6ce2\u5316\u304c\u8a98\u767a\u3055\u308c\u308b\u3068\u4e88\u60f3\u3057\u307e\u3057\u305f\u304c\u3001\u4e88\u60f3\u3068\u306f\u7570\u306a\u308a\u975e\u5e38\u306b\u660e\u308b\u304f\u3086\u3063\u304f\u308a\u3068\u3057\u305f\u5fdc\u7b54\u304c\u5f97\u3089\u308c\u307e\u3057\u305f\u3002<\/span>
        \n \u305d\u3053\u3067\u982d\u84cb\u9aa8\u306b\u89b3\u6e2c\u7528\u306e\u7a93\u3092\u8a2d\u3051\u3001\u4e8c\u5149\u5b50\u9855\u5fae\u93e1\u3092\u7528\u3044\u3066\u3088\u308a\u8a73\u7d30\u306a\u89b3\u6e2c\u3092\u884c\u306a\u3063\u305f\u3068\u3053\u308d\u3001\u3053\u306eCa2+<\/sup>\u30b7\u30b0\u30ca\u30eb\u306f\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u7531\u6765\u3067\u3042\u308b\u3053\u3068\u3092\u898b\u51fa\u3057\u307e\u3057\u305f (\u4e0b\u56f3)\u3002<\/span><\/p>\n

        \"\"<\/span><\/p>\n

        \u30a6\u30ec\u30bf\u30f3\u9ebb\u9154\u4e0b\u306eG7NG817\u30de\u30a6\u30b9\u306b\u304a\u3051\u308b\u30c6\u30fc\u30eb\u30d4\u30f3\u30c1\u523a\u6fc0\u306b\u5bfe\u3059\u308b\u5fdc\u7b54\u306e\u7d4c\u982d\u84cb\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0<\/span>
        \n(\u4e0a\u6bb5) \u86cd\u5149\u8f1d\u5ea6\u5909\u5316\u7387\u3092\u7591\u4f3c\u30ab\u30e9\u30fc\u8868\u793a\u3057\u305f\u3002\u5909\u5316\u7387\u306e\u30d4\u30fc\u30af\u5024\u3068\u5fdc\u7b54\u306e\u6642\u9593\u7d4c\u904e\u304c\u3001\u81ea\u767a\u7684\u306a\u5fdc\u7b54\u306e\u7d0410\u500d\u9ad8\u3044\u5024\u3092\u793a\u3059\u3053\u3068\u306b\u6ce8\u76ee\u3002<\/span>
        \n(\u4e0b\u6bb5) \u4e0a\u6bb5\u3068\u306f\u5225\u306e\u500b\u4f53\u3067\u3001\u4f53\u6027\u611f\u899a\u91ce (\u56f3\u306e\u56db\u89d2\u3067\u56f2\u3063\u305f\u90e8\u4f4d)\u306b\u958b\u982d\u624b\u8853\u3092\u65bd\u3057\u3001\u30c6\u30fc\u30eb\u30d4\u30f3\u30c1\u523a\u6fc0\u306b\u5bfe\u3059\u308b\u76ae\u8cea\u7b2c2\/3\u5c64\u306e\u5fdc\u7b54\u3092\u4e8c\u5149\u5b50\u9855\u5fae\u93e1\u3067\u8a08\u6e2c\u3057\u305f\u3002<\/span>
        \n\u3086\u3063\u304f\u308a\u3068\u3057\u305f\u6642\u9593\u7d4c\u904e\u3067\u975e\u5e38\u306b\u660e\u308b\u304f\u767d\u304f\u898b\u3048\u308b\u7d30\u80de\u306f\u3001\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u3067\u3042\u308b\u3002<\/span><\/p>\n

        \u5fae\u5f31\u306a\u96fb\u6c17\u523a\u6fc0\u304c\u8133\u3092\u6d3b\u6027\u5316\u3059\u308b\u4ed5\u7d44\u307f\u3092\u89e3\u660e<\/span><\/h2>\n

        \u3000\u7d4c\u982d\u84cb\u30de\u30af\u30ed\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u3092\u5229\u7528\u3057\u3066\u3001\u7d4c\u982d\u84cb\u76f4\u6d41\u96fb\u6c17\u523a\u6fc0 (tDCS)\u306e\u4f5c\u7528\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002<\/span>
        \n tDCS\u306f\u3001\u982d\u84cb\u9aa8\u306e\u4e0a\u304b\u3089\u6975\u3081\u3066\u5fae\u5f31\u306a\u96fb\u6d41\u3092\u6d41\u3059\u3053\u3068\u306b\u3088\u3063\u3066\u8133\u3092\u523a\u6fc0\u3059\u308b\u624b\u6cd5\u3067\u3001\u30d2\u30c8\u3067\u306f\u3046\u3064\u75c5\u306e\u6539\u5584\u3084\u3001\u30ea\u30cf\u30d3\u30ea\u30c6\u30fc\u30b7\u30e7\u30f3\u306e\u4fc3\u9032\u3001\u3055\u3089\u306b\u306f\u8a18\u61b6\u529b\u306e\u5411\u4e0a\u306a\u3069\u306e\u52b9\u679c\u304c\u5831\u544a\u3055\u308c\u3066\u304a\u308a\u3001\u69d8\u3005\u306a\u5206\u91ce\u3078\u306e\u5fdc\u7528\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/span>
        \n \u3057\u304b\u3057\u306a\u304c\u3089\u305d\u306e\u4f5c\u7528\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u89e3\u660e\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/span>
        \n \u305d\u3053\u3067\u3001\u899a\u9192\u4e0b\u306eG7NG817\u30de\u30a6\u30b9\u306btDCS\u3092\u884c\u306a\u3063\u305f\u7d50\u679c\u3001\u9a5a\u3044\u305f\u3053\u3068\u306b\u3001\u975e\u5e38\u306b\u660e\u308b\u304f\u3066\u3086\u3063\u304f\u308a\u3068\u3057\u305f\u5fdc\u7b54\u304c\u9855\u8457\u306b\u5897\u52a0\u3057\u307e\u3057\u305f\u3002<\/span><\/p>\n

        \"\"<\/span><\/p>\n

        G7NG817 \u30de\u30a6\u30b9\u306e\u5927\u8133\u76ae\u8cea\u306b\u304a\u3051\u308b tDCS \u4e2d\u306e\u30ab\u30eb\u30b7\u30a6\u30e0\u52d5\u614b<\/span>
        \n\u899a\u9192\u72b6\u614b\u306e\u30de\u30a6\u30b9\u306e\u8133\u3092\u982d\u84cb\u9aa8\u8d8a\u3057\u306b\u4e0a\u304b\u3089\u307f\u3066\u3044\u308b\u3002\u53f3\u8133\u306e\u4e00\u90e8\u306b tDCS \u306e\u967d\u6975\u3092\u7f6e\u304d\u3001\u9670\u6975\u306f\u9996\u306e\u7b4b\u8089\u306b\u8a2d\u7f6e\u3057\u30010.1mA \u3067 10 \u5206\u9593 tDCS \u3092\u884c\u3063\u305f\u3002\u96fb\u6c17\u523a\u6fc0\u958b\u59cb\u76f4\u5f8c\u304b\u3089\u3086\u3063\u304f\u308a\u3068\u3057\u305f\u975e\u5e38\u306b\u660e\u308b\u3044\u30ab\u30eb\u30b7\u30a6\u30e0\u5fdc\u7b54\u304c\u3001\u5de6\u8133\u3092\u542b\u3080\u5927\u8133\u76ae\u8cea\u5168\u4f53\u306b\u308f\u305f\u3063\u3066\u8d77\u3053\u3063\u305f\u3002\u3053\u308c\u306f\u4e00\u904e\u6027\u306e\u5fdc\u7b54\u3067\u3001\u96fb\u6c17\u523a\u6fc0\u3092\u4e0e\u3048\u3066\u3044\u308b\u9593\u3060\u3051\u8457\u3057\u304f\u5897\u52a0\u3057\u305f\u3002<\/span><\/p>\n

        \u4e8c\u5149\u5b50\u9855\u5fae\u93e1\u3067\u89b3\u6e2c\u3057\u305f\u3068\u3053\u308d\u3001\u3053\u306eCa2+<\/sup>\u4e0a\u6607\u306f\u3001\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u7531\u6765\u3067\u3042\u308b\u3053\u3068\u3092\u898b\u51fa\u3057\u307e\u3057\u305f\u3002<\/span>
        \n \u4e00\u65b9\u3001\u30c6\u30fc\u30eb\u30d4\u30f3\u30c1\u3068\u306f\u7570\u306a\u308a\u3001\u30cb\u30e5\u30fc\u30ed\u30f3\u306e\u5fdc\u7b54\u306b\u306f\u5909\u5316\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/span><\/p>\n

        \"\"<\/span><\/p>\n

        tDCS\u306b\u3088\u3063\u3066\u76ae\u8cea\u7b2c2\/3\u5c64\u306e\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u306e\u30ab\u30eb\u30b7\u30a6\u30e0\u4e0a\u6607\u304c\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u3002<\/span>
        \n(A) G7NG817\u30de\u30a6\u30b9\u306b\u304a\u3051\u308btDCS\u4e2d\u306e\u8996\u899a\u76ae\u8cea\u7b2c2\/3\u5c64\u306e\u4e8c\u5149\u5b50\u9855\u5fae\u93e1\u306b\u3088\u308b\u8a08\u6e2c\u3002\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u306fSR101\u3067\u8d64\u306b\u67d3\u8272\u3055\u308c\u3066\u3044\u308b\u3002\u77e2\u5c3b\u306ftDCS\u306b\u3088\u3063\u3066\u7d30\u80de\u5185Ca2+<\/sup>\u4e0a\u6607\u304c\u89b3\u6e2c\u3055\u308c\u305f\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u3092\u793a\u3057\u3066\u3044\u308b\u3002\u6570\u5b57\u306f\u56f3B\u3067\u6642\u7cfb\u5217\u5909\u5316\u304c\u63cf\u304b\u308c\u3066\u3044\u308b\u30cb\u30e5\u30fc\u30ed\u30f3\u3068\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u3068\u30cb\u30e5\u30fc\u30ed\u30b0\u30ea\u30aa\u30d4\u30eb\u306b\u5bfe\u5fdc\u3057\u3066\u3044\u308b\u3002\u30b9\u30b1\u30fc\u30eb\u30d0\u30fc\u306f100 \u03bcm\u3002(B) \u86cd\u5149\u5909\u5316\u7387 (\u0394F\/F)\u306e\u6642\u7cfb\u5217\u5909\u5316\u3002\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u304c\u30aa\u30ec\u30f3\u30b8\u3067\u3001\u30cb\u30e5\u30fc\u30ed\u30f3\u304c\u7dd1\u3067\u3001\u30cb\u30e5\u30fc\u30ed\u30b0\u30ea\u30aa\u30d4\u30eb\u304c\u8336\u8272\u3067\u793a\u3057\u3066\u3042\u308b\u3002<\/span><\/p>\n

        \u85ac\u7406\u5b66\u7684\u5b9f\u9a13\u304b\u3089\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u306eCa2+<\/sup>\u4e0a\u6607\u306f\u3001\u5e83\u7bc4\u56f2\u8abf\u7bc0\u7cfb\u306e\u795e\u7d4c\u4fee\u98fe\u7269\u8cea\u3067\u3042\u308b\u30ce\u30eb\u30a2\u30c9\u30ec\u30ca\u30ea\u30f3\u304c\u5f15\u304d\u91d1\u3068\u306a\u3063\u3066\u751f\u3058\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002<\/span>
        \n tDCS\u306b\u3088\u3063\u3066\u8a98\u5c0e\u3055\u308c\u308b\u30b7\u30ca\u30d7\u30b9\u53ef\u5851\u6027\u3084\u3046\u3064\u69d8\u884c\u52d5\u306e\u6539\u5584\u306b\u3082\u30ce\u30eb\u30a2\u30c9\u30ec\u30ca\u30ea\u30f3\u3092\u4ecb\u3057\u305f\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u306eCa2+<\/sup>\u4e0a\u6607\u304c\u5fc5\u9808\u3067\u3042\u308b\u3053\u3068\u3092\u898b\u51fa\u3057\u307e\u3057\u305f (Monai et al., 2016, Nat. Commun.)\u3002<\/span><\/p>\n

        \"\"<\/span><\/p>\n

        tDCS \u304c\u30de\u30a6\u30b9\u306e\u30b7\u30ca\u30d7\u30b9\u4f1d\u9054\u306e\u5897\u5f37\u3092\u8d77\u3053\u3059\u30e2\u30c7\u30eb<\/span>
        \n\u30de\u30a6\u30b9\u8133\u3078\u306e\u5fae\u5f31\u306a\u76f4\u6d41\u96fb\u6d41(tDCS)\u306b\u3088\u3063\u3066\u30ce\u30eb\u30a2\u30c9\u30ec\u30ca\u30ea\u30f3\u306e\u653e\u51fa\u304c\u4fc3\u9032\u3055\u308c\u3001\u30ce\u30eb\u30a2\u30c9\u30ec\u30ca\u30ea\u30f3\u53d7\u5bb9\u4f53(A1AR)\u3092\u4ecb\u3057\u3066\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u3092\u6d3b\u6027\u5316\u3059\u308b(\u30ab\u30eb\u30b7\u30a6\u30e0\u6fc3\u5ea6\u304c\u4e0a\u6607\u3059\u308b)\u3002\u305d\u306e\u7d50\u679c\u3001\u30b7\u30ca\u30d7\u30b9\u4f1d\u9054\u304c\u5897\u5f37\u3055\u308c\u308b\u3002\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u304c\u4f55\u3089\u304b\u306e\u4f1d\u9054\u7269\u8cea\u3092\u653e\u51fa(\u30b0\u30ea\u30a2\u4f1d\u9054)\u3057\u3066\u3001\u30b7\u30ca\u30d7\u30b9\u6a5f\u80fd\u3092\u8abf\u7bc0\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u60f3\u5b9a\u3055\u308c\u308b\u3002<\/span><\/p>\n

        \u751f\u4f53\u8133\u6df1\u90e8\u89b3\u6e2c\u3068\u8133\u7d44\u7e54\u306e\u751f\u7269\u7269\u7406\u5b66\u7279\u6027\u306e\u89e3\u660e<\/span><\/h2>\n

        \u5927\u8133\u76ae\u8cea\u306b\u304a\u3044\u3066\u306f\u3001\u9577\u304f\u8907\u96d1\u306b\u5206\u679d\u3057\u305f\u795e\u7d4c\u7a81\u8d77\u3092\u6301\u3064\u795e\u7d4c\u7d30\u80de\u304c\u65b9\u5411\u6027\u3092\u6301\u3063\u3066\u914d\u5217\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u6a5f\u80fd\u9818\u91ce\u3092\u5f62\u6210\u3057\u3066\u3044\u307e\u3059\u3002<\/span>
        \n \u6a5f\u80fd\u9818\u91ce\u5185\u3067\u306f\u3001\u6df1\u3055\u65b9\u5411\u306b\u5206\u5e03\u3059\u308b\u7d30\u80de\u306e\u7a2e\u985e\u3084\u5f62\u614b\u3084\u5206\u5e03\u306e\u5bc6\u5ea6\u304c\u7570\u306a\u308b\u5c64\u69cb\u9020\u3092\u306a\u3057\u3001\u5c64\u9593\u3067\u306e\u76f8\u4e92\u4f5c\u7528\u306b\u3088\u308a\u60c5\u5831\u51e6\u7406\u3092\u9054\u6210\u3057\u3066\u3044\u307e\u3059\u3002<\/span>
        \n \u3055\u3089\u306b\u6a5f\u80fd\u9818\u91ce\u304c\u76f8\u4e92\u306b\u9023\u7d61\u3059\u308b\u3053\u3068\u3067\u9ad8\u6b21\u6a5f\u80fd\u3092\u9054\u6210\u3057\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/span>
        \n \u3053\u306e\u3088\u3046\u306b\u672c\u6765\u8907\u96d1\u306a\u69cb\u6210\u3092\u6301\u3064\u8133\u7d44\u7e54\u306b\u5bfe\u3057\u3066\u3001\u3053\u308c\u307e\u3067\u306f\u500b\u3005\u306e\u795e\u7d4c\u7d30\u80de\u306e\u5185\u90e8\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u3084\u5206\u5b50\u306e\u52d5\u614b\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u8981\u7d20\u9084\u5143\u8ad6\u7684\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\u3084\u795e\u7d4c\u7d30\u80de\u9593\u306e\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u69cb\u9020\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u30b7\u30b9\u30c6\u30e0\u8ad6\u7684\u30a2\u30d7\u30ed\u30fc\u30c1\u304c\u53d6\u3089\u308c\u3066\u304d\u307e\u3057\u305f\u3002<\/span>
        \n \u8133\u7d44\u7e54\u3092\u69cb\u6210\u3059\u308b\u7d30\u80de\u96c6\u56e3\u306e\u914d\u7f6e\u3084\u7d44\u7e54\u306e\u5f62\u614b\u3084\u69cb\u9020\u306b\u7740\u76ee\u3057\u305f\u7814\u7a76\u304c\u91cd\u8981\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/span>
        \n \u8133\u7d44\u7e54\u306f\u5f93\u6765\u8102\u8cea\u304b\u3089\u306a\u308b\u5747\u8cea\u306a\u5a92\u8cea\u3067\u3042\u308b\u3068\u307f\u306a\u3055\u308c\u3066\u3044\u308b\u3088\u3046\u3067\u3059\u304c\u3001\u8133\u7d44\u7e54\u306e\u6301\u3064\u69cb\u6210\u7684\u306a\u7279\u6027\u3084\u5f62\u614b\u7684\u306a\u898f\u5247\u6027\u306f\u975e\u5e38\u306b\u8208\u5473\u6df1\u304f\u601d\u3048\u307e\u3059\u3002<\/span>
        \n \u79c1\u306f\u3053\u308c\u307e\u3067\u3001\u8133\u7d44\u7e54\u306e\u6301\u3064\u7570\u65b9\u6027\u304c\u8133\u7d44\u7e54\u306e\u7269\u7406\u7684\u7279\u6027\u3084\u751f\u4f53\u8133\u306b\u304a\u3051\u308b\u6a5f\u80fd\u5275\u6210\u306b\u5bfe\u3057\u3066\u5927\u304d\u304f\u5bc4\u4e0e\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u3092\u63d0\u6848\u3057\u3066\u53c2\u308a\u307e\u3057\u305f (Monai et al., Phys Rev. E., 2012)\u3002<\/span><\/p>\n

        \u672c\u7814\u7a76\u3067\u306f\u3001\u8133\u7d44\u7e54\u3068\u308a\u308f\u3051\u9ad8\u6b21\u6a5f\u80fd\u3092\u62c5\u3063\u3066\u3044\u308b\u3068\u8a00\u308f\u308c\u3066\u3044\u308b\u5927\u8133\u76ae\u8cea\u306e\u6a5f\u80fd\u9818\u91ce\u306e\u5c64\u69cb\u9020\u3084\u7570\u65b9\u6027\u306b\u7740\u76ee\u3057\u3066\u53c2\u308a\u307e\u3059\u3002<\/span>
        \n \u751f\u4f53\u8133\u306b\u304a\u3051\u308b\u76ae\u8cea\u7d44\u7e54\u304c\u4e0d\u5747\u8cea\u5a92\u8cea\u3067\u3042\u308b\u3053\u3068\u3084\u5358\u306a\u308b\u8102\u8cea\u304b\u3089\u306a\u308b\u5a92\u8cea\u3067\u306a\u3044\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u305f\u4e0a\u3067\u3001\u7d44\u7e54\u306e\u4e0d\u5747\u8cea\u6027\u3084\u7570\u65b9\u6027\u304c\u8133\u6a5f\u80fd\u306e\u5275\u6210\u306b\u679c\u305f\u3059\u5f79\u5272\u3092\u89e3\u660e\u3057\u305f\u3044\u3068\u8003\u3048\u3066\u304a\u308a\u307e\u3059\u3002<\/span><\/p>\n

        \u672c\u7814\u7a76\u306f\u7406\u7814BSI-\u30aa\u30ea\u30f3\u30d1\u30b9\u9023\u643a\u30bb\u30f3\u30bf\u30fc (BOCC)\u3068\u306e\u5171\u540c\u7814\u7a76\u3067\u884c\u306a\u3063\u3066\u3044\u304f\u4e88\u5b9a\u3067\u3059\u3002<\/span><\/p>\n

        \"\"<\/span><\/p>\n

        \u5927\u8133\u76ae\u8cea\u306e\u898f\u5247\u6b63\u3057\u3044\u5c64\u69cb\u9020<\/span>
        \n\u795e\u7d4c\u7d30\u80de\u306e\u7d30\u80de\u8cea\u306bYFP\u3092\u767a\u73fe\u3057\u305f\u907a\u4f1d\u5b50\u6539\u5909\u30de\u30a6\u30b9\u3088\u308a\u4f5c\u6210\u3057\u305f\u8133\u5207\u7247\u306e\u56f3\u3068\u611f\u899a\u76ae\u8cea\u306b\u304a\u3051\u308b\u4e8c\u5149\u5b50\u50cf\u3088\u308a\u4e09\u6b21\u5143\u518d\u69cb\u6210\u3057\u305f\u795e\u7d4c\u7a81\u8d77\u7fa4\u3002\u795e\u7d4c\u7d30\u80de\u306e\u795e\u7d4c\u7a81\u8d77\u306f\u898f\u5247\u6b63\u3057\u304f\u914d\u5217\u3057\u3066\u304a\u308a\u3001\u3055\u3089\u306b\u6df1\u3055\u65b9\u5411\u306b\u304a\u3044\u3066\u3082\u7a81\u8d77\u306e\u4f38\u9577\u65b9\u5411\u306b\u898f\u5247\u6027\u304c\u3042\u308b\u3002\u64ae\u5f71\u306f\u7406\u7814BSI-\u30aa\u30ea\u30f3\u30d1\u30b9\u9023\u643a\u30bb\u30f3\u30bf\u30fc\u306e\u5354\u529b\u3092\u5f97\u3066\u3001FVMPE-RS\u4e8c\u5149\u5b50\u52b1\u8d77\u9855\u5fae\u93e1\u306b\u3066\u3001WMP25x \u6c34\u6d78\u5bfe\u7269\u30ec\u30f3\u30ba\u3092\u7528\u3044\u3066\u884c\u306a\u3063\u305f\u3002<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

        \u2606\u76ee\u6b21 \u306f\u3058\u3081\u306b \u53c2\u8003\u30fb\u63a8\u85a6\u56f3\u66f8 \u4ee3\u8868\u7684\u306a\u8ad6\u6587 \u7814\u7a76\u30c6\u30fc\u30de\u306e\u4f8b News and Media G7NG817\u907a\u4f1d\u5b50\u6539\u5909\u30de\u30a6\u30b9\u306b\u3088\u308b\u751f\u4f53\u8133Ca2+\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0 \u5fae\u5f31\u306a\u96fb\u6c17\u523a\u6fc0\u304c\u8133\u3092\u6d3b\u6027\u5316\u3059\u308b\u4ed5\u7d44\u307f\u3092\u89e3\u660e \u751f\u4f53\u8133\u6df1\u90e8\u89b3\u6e2c\u3068\u8133 … \u7d9a\u304d\u3092\u8aad\u3080 \u7814\u7a76\u5185\u5bb9<\/span> →<\/span><\/a><\/p>\n","protected":false},"author":37,"featured_media":0,"parent":0,"menu_order":4,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-106","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www-p.sci.ocha.ac.jp\/bio-monai-lab\/wp-json\/wp\/v2\/pages\/106","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www-p.sci.ocha.ac.jp\/bio-monai-lab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www-p.sci.ocha.ac.jp\/bio-monai-lab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www-p.sci.ocha.ac.jp\/bio-monai-lab\/wp-json\/wp\/v2\/users\/37"}],"replies":[{"embeddable":true,"href":"https:\/\/www-p.sci.ocha.ac.jp\/bio-monai-lab\/wp-json\/wp\/v2\/comments?post=106"}],"version-history":[{"count":54,"href":"https:\/\/www-p.sci.ocha.ac.jp\/bio-monai-lab\/wp-json\/wp\/v2\/pages\/106\/revisions"}],"predecessor-version":[{"id":2394,"href":"https:\/\/www-p.sci.ocha.ac.jp\/bio-monai-lab\/wp-json\/wp\/v2\/pages\/106\/revisions\/2394"}],"wp:attachment":[{"href":"https:\/\/www-p.sci.ocha.ac.jp\/bio-monai-lab\/wp-json\/wp\/v2\/media?parent=106"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}