{"id":776,"date":"2017-06-20T13:44:05","date_gmt":"2017-06-20T04:44:05","guid":{"rendered":"http:\/\/www-p.cc.ocha.ac.jp\/bio-miyamoto-lab\/?page_id=776"},"modified":"2017-06-20T13:44:05","modified_gmt":"2017-06-20T04:44:05","slug":"research","status":"publish","type":"page","link":"https:\/\/www-p.sci.ocha.ac.jp\/bio-miyamoto-lab\/research.html","title":{"rendered":"\u7814\u7a76\u5185\u5bb9"},"content":{"rendered":"

\uff08\uff11\uff09\u5c0f\u8133\u9846\u7c92\u524d\u99c6\u7d30\u80de\u306e\u5897\u6b96\u5206\u5316\u30fb\u7a81\u8d77\u5f62\u6210\u306b\u304a\u3051\u308b\u7d30\u80de\u5916\u30de\u30c8\u30ea\u30c3\u30af\u30b9\u5206\u5b50\u306e\u5f79\u5272<\/h2>\n

\u5c0f\u8133\u5f62\u6210\u306f\u3001\u30de\u30a6\u30b9\u306e\u5834\u5408\u51fa\u7523\u5f8c\u306b\u884c\u308f\u308c\u308b\u3002\u5c0f\u8133\u3067\u306f\u4e3b\u306b2\u7a2e\u306e\u795e\u7d4c\u7d30\u80de\uff08\u9846\u7c92\u7d30\u80de\u3001\u30d7\u30eb\u30ad\u30f3\u30a8\u7d30\u80de\uff09\u304b\u3089\u5f62\u6210\u3055\u308c\u308b\u3002\u5c0f\u8133\u5f62\u6210\u6642\u306b\u304a\u3044\u3066\u3001\u307e\u305a\u3001\u5897\u6b96\u80fd\u3092\u6709\u3059\u308b\u5c0f\u8133\u9846\u7c92\u524d\u99c6\u7d30\u80de\u304b\u3089\u306a\u308b\u5916\u9846\u7c92\u5c64\u306b\u304a\u3044\u3066\u3001\u7d30\u80de\u5468\u671f\u3092\u8131\u3057\u3066\u3001\u521d\u671f\u5206\u5316\u72b6\u614b\u306b\u5165\u308a\u3001\u5206\u5b50\u5c64\u306b\u304a\u3044\u3066\u8ef8\u7d22\u304c\u5f62\u6210\u30fb\u4f38\u9577\u3055\u308c\u3001\u30d7\u30eb\u30ad\u30f3\u30a8\u7d30\u80de\u3068\u795e\u7d4c\u56de\u8def\u3092\u5f62\u6210\u3057\u3066\u3044\u304f\u3002\u3053\u306e\u904e\u7a0b\u306b\u304a\u3044\u3066\u5c64\u304c\u5f62\u6210\u3055\u308c\u308b\u305f\u3081\u306b\u306f\u3001\u5c0f\u8133\u9846\u7c92\u524d\u99c6\u7d30\u80de\u306e\u5897\u6b96\u3001\u5206\u5316\u3001\u7a81\u8d77\u5f62\u6210\u304c\u3001\u6642\u9593\u7684\u3001\u7a7a\u9593\u7684\u306b\u7cbe\u7dfb\u306b\u5236\u5fa1\u3055\u308c\u3066\u3044\u308b\u5fc5\u8981\u304c\u3042\u308b\u3002\u56fd\u5185\u5916\u306e\u7814\u7a76\u306b\u3088\u308a\u3001\u305d\u306e\u5206\u5b50\u30ec\u30d9\u30eb\u3067\u306e\u3057\u304f\u307f\u306b\u7d30\u80de\u5185\u5916\u306e\u69d8\u3005\u306a\u56e0\u5b50\u304c\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u304d\u3066\u3044\u308b\u304c\u3001\u305d\u306e\u7406\u89e3\u306f\u672a\u3060\u306b\u5341\u5206\u3067\u306f\u306a\u3044\u3002<\/p>\n

\u5bae\u672c\u7814\u7a76\u5ba4\u3067\u306f\u3001\u767a\u751f\u671f\u306e\u5c0f\u8133\u306b\u304a\u3044\u3066\u767a\u73fe\u304c\u4e00\u904e\u6027\u306b\u898b\u3089\u308c\u308b\u7d30\u80de\u5916\u30de\u30c8\u30ea\u30c3\u30af\u30b9\u5206\u5b50\u306e\u4e00\u3064\u30d3\u30c8\u30ed\u30cd\u30af\u30c1\u30f3\u3092\u59cb\u3081\u3068\u3057\u305f\u7d30\u80de\u5916\u30de\u30c8\u30ea\u30c3\u30af\u30b9\u3084\u7d30\u80de\u63a5\u7740\u5206\u5b50\u306b\u7740\u76ee\u3057\u3001\u5c0f\u8133\u9846\u7c92\u524d\u99c6\u7d30\u80de\u306e\u5897\u6b96\u3001\u5206\u5316\u3001\u7a81\u8d77\u5f62\u6210\u306b\u53ca\u307c\u3059\u5bc4\u4e0e\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u3053\u3068\u3092\u9032\u3081\u3066\u304d\u3066\u3044\u308b\u3002<\/p>\n

\"\"<\/p>\n

\u30d3\u30c8\u30ed\u30cd\u30af\u30c1\u30f3\u304c\u3001\u5c0f\u8133\u9846\u7c92\u524d\u99c6\u7d30\u80de\u306e\u521d\u671f\u5206\u5316\u3092\u4fc3\u9032\u3055\u305b\u308b\u3053\u3068\u3092\u898b\u51fa\u3057\u305f<\/h3>\n

\u5bae\u672c\u7814\u7a76\u5ba4\u3067\u306f\u3001\u30d3\u30c8\u30ed\u30cd\u30af\u30c1\u30f3-\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u30de\u30a6\u30b9\u3092\u7528\u3044\u3001\u5c0f\u8133\u5f62\u6210\u6642\uff08\u751f\u5f8c\uff12\u65e5\u76ee\u304b\u308914\u65e5\u76ee\uff09\u306e\u7d44\u7e54\u5207\u7247\u3092\u4f5c\u6210\u3057\u3001\u30d3\u30c8\u30ed\u30cd\u30af\u30c1\u30f3\u306e\u5c0f\u8133\u5f62\u6210\u3078\u306e\u5f71\u97ff\u306b\u3064\u3044\u3066\u89e3\u6790\u3092\u884c\u3063\u305f\u3002\u521d\u671f\u5206\u5316\u6bb5\u968e\u3078\u306e\u30d3\u30c8\u30ed\u30cd\u30af\u30c1\u30f3\u6b20\u640d\u306e\u5f71\u97ff\u3092\u521d\u671f\u5206\u5316\u30de\u30fc\u30ab\u30fcTAG1\u3092\u7528\u3044\u3066\u89e3\u6790\u3057\u305f\u3068\u3053\u308d\u3001\u30d3\u30c8\u30ed\u30cd\u30af\u30c1\u30f3\u6b20\u640d\u306b\u3088\u308a\u5c0f\u8133\u9846\u7c92\u524d\u99c6\u7d30\u80de\u306e\u521d\u671f\u5206\u5316\u6bb5\u968e\u306e\u7d30\u80de\u6570\u306e\u5897\u5927\u304c\u89b3\u5bdf\u3055\u308c\u305f\u3002\u3053\u306e\u73fe\u8c61\u304c\u5c0f\u8133\u9846\u7c92\u524d\u99c6\u7d30\u80de\u306e\u521d\u4ee3\u57f9\u990a\u7cfb\u306b\u304a\u3044\u3066\u3082\u89b3\u5bdf\u3055\u308c\u305f\u3002\u3053\u308c\u3089\u306e\u7d50\u679c\u304b\u3089\u30d3\u30c8\u30ed\u30cd\u30af\u30c1\u30f3 \u304c\u5c0f\u8133\u9846\u7c92\u524d\u99c6\u7d30\u80de\u306e\u521d\u671f\u5206\u5316\u306e\u9032\u884c\u3092\u4fc3\u9032\u3055\u305b\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f\uff08Hashimoto et al.,<\/em> 2016\uff09\u3002<\/p>\n

\n
\n
<\/div>
\"\"\"\"\"\"<\/div><\/div>\n \n <\/div>\n<\/div>\n

\uff08\uff12\uff09\u5927\u8133\u640d\u50b7\u4fee\u5fa9\u306b\u304a\u3051\u308b\u7d30\u80de\u5916\u30de\u30c8\u30ea\u30c3\u30af\u30b9\u5206\u5b50\u306e\u5f79\u5272<\/h2>\n

\u4ea4\u901a\u4e8b\u6545\u3084\u30b9\u30dd\u30fc\u30c4\u4e8b\u6545\u306a\u3069\u3067\u8133\u306b\u751f\u3058\u308b\u5916\u50b7\u6027\u8133\u640d\u50b7\u306f\u3001\u76f4\u63a5\u7684\u306b\u306f\u7269\u7406\u7684\u306a\u640d\u50b7\u3067\u3042\u308a\u3001\u305d\u306e\u6cbb\u7642\u3068\u3057\u3066\u306f\u3001\u307e\u305a\u982d\u304c\u3044\u9aa8\u9aa8\u6298\u3084\u51fa\u8840\u306b\u5bfe\u3059\u308b\u5916\u79d1\u7684\u306a\u6cbb\u7642\u304c\u4e3b\u8981\u306a\u51e6\u7f6e\u3067\u3042\u308b\u3002\u3057\u304b\u3057\u3001\u5916\u50b7\u6027\u8133\u640d\u50b7\u60a3\u8005\u306b\u3068\u3063\u3066\u5927\u304d\u306a\u554f\u984c\u306f\u3001\u305d\u306e\u5f8c\u306b \u751f\u3058\u308b\u5f8c\u907a\u75c7\u3067\u3042\u308b\u3002\u5f8c\u907a\u75c7\u3068\u3057\u3066\u3001\u6ce8\u610f\u529b\u4f4e\u4e0b\u3001\u9042\u884c\u6a5f\u80fd\u969c\u5bb3\u3001\u8131\u6291\u5236\u75c7\u72b6\u306a\u3069\u9ad8\u6b21\u6a5f\u80fd\u306e\u50b7\u5bb3\u304c\u898b\u3089\u308c\u3001\u751f\u6d3b\u306e\u8cea\uff08Quality of Life, QOL\uff09\u306e\u4f4e\u4e0b\u304c\u304a\u3053\u308b\u3002\u3053\u306e\u5f8c\u907a\u75c7\u306b\u306f\u3001\u5916\u50b7\u6027\u8133\u640d\u50b7\u306e\u4e00\u6b21\u7684\u306a\u640d\u50b7\uff08\u7269\u7406\u7684\u306a\u640d\u50b7\uff09\u3088\u308a\u3001\u4e8c\u6b21\u7684\u306a\u640d\u50b7\u304c\u5f37\u304f\u5f71\u97ff\u3057\u3066\u304a\u308a\u3001\u305d\u306e\u5f71\u97ff\u3068\u306f\u3001\u640d\u50b7\u90e8\u4f4d\u3067\u8d77\u3053\u308b\u708e\u75c7\u306b\u7531\u6765\u3059\u308b\u3002 \u708e\u75c7\u304c\u5468\u56f2\u306e\u795e\u7d4c\u7d30\u80de\u306e\u5909\u6027\u306b\u3088\u308b\u795e\u7d4c\u7d30\u80de\u6b7b\u3092\u5f15\u304d\u8d77\u3053\u3059\u3002\u3053\u306e\u4e8c\u6b21\u7684\u306a\u640d\u50b7\u3092\u3044\u304b\u306b\u6291\u3048\u308b\u304b\u304c\u3001\u5f8c\u907a\u75c7\u306e\u6539\u5584\u306b\u5927\u304d\u304f\u95a2\u308f\u3063\u3066\u304f\u308b\u3002\u3057\u304b\u3057\u3001\u3053\u306e\u4e8c\u6b21\u7684\u306a\u640d\u50b7\u3092\u6291\u3048\u308b\u6709\u52b9\u306a\u6cbb\u7642\u85ac\u306f\u3044\u307e\u3060\u958b\u767a\u3055\u308c\u3066\u3044\u306a\u3044\u3002<\/p>\n

\u5bae\u672c\u7814\u7a76\u5ba4\u3067\u306f\u3001\u30de\u30a6\u30b9\u306e\u5927\u8133\u76ae\u8cea\u306b\u5bfe\u3057\u3066\u3001\u6ce8\u5c04\u91dd\u3092\u7528\u3044\u305f\u7a7f\u523a\u50b7\u5bb3\u3092\u4e0e\u3048\u3001\u305d\u306e\u8133\u640d\u50b7\u4fee\u5fa9\u306b\u5bfe\u3059\u308b\u30d3\u30c8\u30ed\u30cd\u30af\u30c1\u30f3\u3092\u59cb\u3081\u3068\u3057\u305f\u7d30\u80de\u5916\u30de\u30c8\u30ea\u30c3\u30af\u30b9\u5206\u5b50\u306e\u5f79\u5272\u3092\u89e3\u6790\u3057\u3066\u3044\u308b\u3002\u30d3\u30c8\u30ed\u30cd\u30af\u30c1\u30f3\u6b20\u640d\u30de\u30a6\u30b9\u306b\u304a\u3044\u3066\u3001\u7dda\u6eb6\u7cfb\u4fc3\u9032\u306b\u3088\u308b\u51fa\u8840\u306e\u4fc3\u9032\u304c\u89b3\u5bdf\u3055\u308c\u3066\u304a\u308a\u3001\u30d3\u30c8\u30ed\u30cd\u30af\u30c1\u30f3\u306e\u51fa\u8840\u6291\u5236\u52b9\u679c\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u308b\u3002\u307e\u305f\u3001\u30d3\u30c8\u30ed\u30cd\u30af\u30c1\u30f3\u306e\u8840\u6db2\u8133\u95a2\u9580\u306e\u4fee\u5fa9\u3078\u306e\u5bc4\u4e0e\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u308b\u3002<\/p>\n

\"\"<\/a>

\u53f3\u8133\u5927\u8133\u76ae\u8cea\u306b\u7a7f\u523a\u50b7\u5bb3\uff08\u6fc3\u3044\u8336\u8272\u306e\u90e8\u4f4d\u304c\u640d\u50b7\u90e8\u4f4d\uff09<\/p><\/div>\n

\uff08\uff13\uff09\u74b0\u72b6\u30db\u30b9\u30d5\u30a1\u30c1\u30b8\u30f3\u9178\u306e\u5927\u8133\u640d\u50b7\u4fee\u5fa9\u306b\u304a\u3051\u308b\u5f79\u5272<\/h2>\n

\u5916\u50b7\u6027\u8133\u640d\u50b7\u306e\u4e8c\u6b21\u7684\u306a\u640d\u50b7\u3092\u6291\u3048\u308b\u7269\u8cea\u3068\u3057\u3066\u3001\u30ea\u30be\u30ea\u30f3\u8102\u8cea\u306e\u4e00\u3064\u3067\u3042\u308b\u74b0\u72b6\u30db\u30b9\u30d5\u30a1\u30c1\u30b8\u30f3\u9178(cyclic phosphatidic acid; cPA)\u306b\u5bae\u672c\u7814\u7a76\u5ba4\u3067\u306f\u3001\u671f\u5f85\u3057\u3066\u3044\u308b\u3002cPA \u306f\u5ba4\u4f0f\u304d\u307f\u5b50\u5148\u751f\u304c\u767a\u898b\u3055\u308c\u305f\u751f\u4f53\u5185\u306b\u5b58\u5728\u3059\u308b\u751f\u7406\u6d3b\u6027\u8102\u8cea\u3067\u3042\u308a\u3001\u54fa\u4e73\u985e\u3067\u306f\u8840\u6e05\u3001 \u8133\u7d44\u7e54\u306b\u8c4a\u5bcc\u306b\u5b58\u5728\u3057\u3001sn -2\u3068 sn -3\u306b\u74b0\u72b6\u69cb\u9020\u3092\u6301\u3064\u3002\u5171\u540c\u7814\u7a76\u8005\u306e\u5ba4\u4f0f\u5148\u751f\u3001\u5f8c\u85e4\u5148\u751f\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001cPA \u306f\u30de\u30a6\u30b9\u306e\u591a\u767a\u6027 \u786c\u5316\u75c7\u30e2\u30c7\u30eb\u306b\u304a\u3044\u3066\u8131\u9ac4\u3001\u30a2\u30b9\u30c8\u30ed\u30b0\u30ea\u30a2\u5897\u6b96\u75c7\u3001\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u6d3b\u6027\u3001\u904b\u52d5\u6a5f\u80fd\u969c\u5bb3\u3092\u6291\u5236\u3059\u308b\u3068\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u3002\u3053\u306e\u3053\u3068\u306f\u3001cPA \u306f\u708e\u75c7\u3092\u6291\u5236\u3057\u3001\u795e\u7d4c\u3092\u4fdd\u8b77\u3059\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u308b\u3002\u305d\u3053\u3067\u3001cPA\u306e\u30de\u30a6\u30b9\u8133\u7a7f\u523a\u50b7\u5bb3\u306e\u4fee\u5fa9\u904e\u7a0b\u306b\u5bfe\u3059\u308bcPA\u306e\u5f71\u97ff\u3092\u89e3\u6790\u3057\u3066\u3044\u308b\u3002<\/p>\n

\"\"<\/a>

\u74b0\u72b6\u30db\u30b9\u30d5\u30a1\u30c1\u30b8\u30f3\u9178\uff08cPA\uff09\u306e\u5206\u5b50\u69cb\u9020<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

\uff08\uff11\uff09\u5c0f\u8133\u9846\u7c92\u524d\u99c6\u7d30\u80de\u306e\u5897\u6b96\u5206\u5316\u30fb\u7a81\u8d77\u5f62\u6210\u306b\u304a\u3051\u308b\u7d30\u80de\u5916\u30de\u30c8\u30ea\u30c3\u30af\u30b9\u5206\u5b50\u306e\u5f79\u5272 \u5c0f\u8133\u5f62\u6210\u306f\u3001\u30de\u30a6\u30b9\u306e\u5834\u5408\u51fa\u7523\u5f8c\u306b\u884c\u308f\u308c\u308b\u3002\u5c0f\u8133\u3067\u306f\u4e3b\u306b2\u7a2e\u306e\u795e\u7d4c\u7d30\u80de\uff08\u9846\u7c92\u7d30\u80de\u3001\u30d7\u30eb\u30ad\u30f3\u30a8\u7d30\u80de\uff09\u304b\u3089\u5f62\u6210\u3055\u308c\u308b\u3002\u5c0f\u8133\u5f62\u6210\u6642\u306b\u304a\u3044\u3066\u3001\u307e\u305a\u3001\u5897 … \u7d9a\u304d\u3092\u8aad\u3080 →<\/span><\/a><\/p>\n","protected":false},"author":31,"featured_media":0,"parent":0,"menu_order":2,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-776","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www-p.sci.ocha.ac.jp\/bio-miyamoto-lab\/wp-json\/wp\/v2\/pages\/776","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www-p.sci.ocha.ac.jp\/bio-miyamoto-lab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www-p.sci.ocha.ac.jp\/bio-miyamoto-lab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www-p.sci.ocha.ac.jp\/bio-miyamoto-lab\/wp-json\/wp\/v2\/users\/31"}],"replies":[{"embeddable":true,"href":"https:\/\/www-p.sci.ocha.ac.jp\/bio-miyamoto-lab\/wp-json\/wp\/v2\/comments?post=776"}],"version-history":[{"count":0,"href":"https:\/\/www-p.sci.ocha.ac.jp\/bio-miyamoto-lab\/wp-json\/wp\/v2\/pages\/776\/revisions"}],"wp:attachment":[{"href":"https:\/\/www-p.sci.ocha.ac.jp\/bio-miyamoto-lab\/wp-json\/wp\/v2\/media?parent=776"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}