{"id":620,"date":"2022-01-24T11:55:49","date_gmt":"2022-01-24T02:55:49","guid":{"rendered":"http:\/\/www-p.sci.ocha.ac.jp\/bio-atsuko\/?page_id=620"},"modified":"2025-05-20T18:19:51","modified_gmt":"2025-05-20T09:19:51","slug":"salone","status":"publish","type":"page","link":"https:\/\/www-p.sci.ocha.ac.jp\/bio-atsuko\/salone.html","title":{"rendered":"Salone"},"content":{"rendered":"<p>\u540d\u8457\u306b\u89aa\u3057\u3082\u3046\u3002\u6b7b\u8005\u305f\u3061\u306e\u8a00\u8449\u306b\u8033\u3092\u50be\u3051\u308c\u3070\u3001\u5e78\u305b\u306b\u306a\u308c\u308b\u3088\u3002<\/p>\n<p>-Leonardo Da Vinci, \u30d1\u30ea\u624b\u7a3fI<\/p>\n<p>&nbsp;<\/p>\n<p>\u3053\u306e\u30b3\u30fc\u30ca\u30fc\u3067\u306f\u3001\u74b0\u5883\u767a\u751f\u9032\u5316\u5b66\u306b\u95a2\u5fc3\u3092\u6301\u3064\u65b9\u306b\u306b\u3068\u3063\u3066\u306e\u5fc5\u8aad\u66f8\u3068\u601d\u308f\u308c\u308b\u53e4\u5178\u3092\u3001\u53b3\u9078\u3057\u3066\u3054\u7d39\u4ecb\u3057\u307e\u3059\u3002<\/p>\n<h2>Physiological Genetics by Rechard Goldschmidt (1939)<\/h2>\n<p style=\"text-align: left\">\u3000\u300cHopeful Monster\u300d\u306e\u8a00\u8449\u3067\u6709\u540d\u306aRichard Goldschimidt\u304c\u3001\u5f53\u6642\u307e\u3060\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u306a\u304b\u3063\u305f\u300c\u907a\u4f1d\u5b50\u300d\u306e\u6b63\u4f53\u306b\u8feb\u3063\u305f\u672c\u3002Phenocopy\u3084Penetrance\u306a\u3069\u3001\u30e1\u30f3\u30c7\u30eb\u306e\u907a\u4f1d\u5b66\u3067\u306f\u8aac\u660e\u304c\u3064\u304b\u306a\u3044\u73fe\u8c61\u3092\u6b21\u3005\u3068\u3068\u308a\u3042\u3052\u3001\u907a\u4f1d\u5b50\u3068\u306f?\u7a81\u7136\u5909\u7570\u3068\u306f?\u767a\u751f\u306e\u30d1\u30bf\u30fc\u30cb\u30f3\u30b0\u3068\u306f?\u3068\u3044\u3063\u305f\u7591\u554f\u306b\u92ed\u3044\u8003\u5bdf\u3092\u3057\u3001\u751f\u7269\u306e\u5185\u90e8\u74b0\u5883\u306e\u307f\u306a\u3089\u305a\u5916\u90e8\u74b0\u5883\u304c\u3001\u767a\u751f\u306e\u30d1\u30bf\u30fc\u30cb\u30f3\u30b0\u3001\u7279\u306b\u4f53\u8272\u3084\u7fbd\u306e\u6a21\u69d8\u3068\u3044\u3063\u305f\u30d1\u30bf\u30fc\u30cb\u30f3\u30b0\u3068\u5207\u3063\u3066\u3082\u5207\u308c\u306a\u3044\u95a2\u4fc2\u304c\u3042\u308b\u3068\u3044\u3046\u3053\u3068\u3092\u8ff0\u3079\u3066\u3044\u307e\u3059\u3002\u9032\u5316\u306b\u76f4\u63a5\u7d50\u3073\u4ed8\u3051\u3066\u306f\u3044\u307e\u305b\u3093\u304c\u3001\u9032\u5316\u3068\u306e\u95a2\u9023\u3092\u601d\u308f\u305b\u308b\u4f8b\u3084\u3001\u307e\u3060\u307e\u3060\u73fe\u4ee3\u306e\u79d1\u5b66\u306b\u7167\u3089\u3057\u5408\u308f\u305b\u305f\u7814\u7a76\u304c\u5fc5\u8981\u3068\u601d\u308f\u308c\u308b\u4e8b\u4f8b\u3082\u305f\u304f\u3055\u3093\u51fa\u3066\u304d\u307e\u3059\u3002\u534a\u4e16\u7d00\u4ee5\u4e0a\u524d\u306b\u3001\u3053\u3093\u306a\u3053\u3068\u307e\u3067\u5206\u304b\u3063\u3066\u3044\u305f\u306e\u304b\u3001\u3068\u76ee\u304b\u3089\u9c57\u3067\u3059\u3002\u7814\u7a76\u3092\u59cb\u3081\u308b\u524d\u306b\u3001\u5c11\u3057\u7acb\u3061\u6b62\u307e\u3063\u3066\u3001\u3053\u306e\u672c\u3092\u8aad\u3093\u3067\u307f\u3066\u306f\u3044\u304b\u304c\u3067\u3057\u3087\u3046\u3002<\/p>\n<p>&nbsp;<\/p>\n<h2>The Strategy of the Genes, by Conrad Hal Waddington (1957)<\/h2>\n<p style=\"text-align: left\">\u8457\u540d\u306a\u54f2\u5b66\u8005Whitehead\u306e\u540d\u8a00\u300c\u79d1\u5b66\u306b\u304a\u3051\u308b\u5049\u696d\u306f\u3001\u60f3\u50cf\u306e\u98db\u8e8d(flight of imagination)\u306b\u3042\u308b\u300d\u3092\u3001\u307e\u3055\u306b\u5177\u73fe\u5316\u3057\u305f\u3088\u3046\u306a\u672c\u3002\u907a\u4f1d\u5b50\u304c\u3069\u306e\u3088\u3046\u306b\u3057\u3066\u767a\u751f\u3092\u5236\u5fa1\u3057\u3066\u3044\u308b\u306e\u304b\u304c\u307e\u3060\u3088\u304f\u308f\u304b\u3063\u3066\u3044\u306a\u304b\u3063\u305f\u6642\u4ee3\u306b\u3001\u300c\u30b7\u30b9\u30c6\u30e0\u300d\u3068\u3044\u3046\u6982\u5ff5\u3092\u3082\u305f\u3089\u3057\u3001\u300c\u60f3\u50cf\u306e\u98db\u8e8d\u300d\u306b\u3088\u3063\u3066\u3001\u74b0\u5883\u3001\u767a\u751f\u3001\u9032\u5316\u3092\u3064\u306a\u304e\u307e\u3057\u305f\u3002\u898b\u3048\u306a\u3044\u4e16\u754c\u3092\u898b\u3048\u308b\u5f62\u306b\u3059\u308b\u3001\u3068\u3044\u3046\u306e\u306f\u3053\u306e\u3053\u3068\u304b\u3068\u3001\u4f55\u5ea6\u8aad\u3093\u3067\u3082\u611f\u52d5\u3057\u307e\u3059\u3002\u30b7\u30b9\u30c6\u30e0\u306e\u6982\u5ff5\u3060\u3051\u3067\u306a\u304f\u3001\u74b0\u5883\u306e\u5f71\u97ff\u304c\u3069\u306e\u3088\u3046\u306b\u9032\u5316\u3068\u95a2\u4fc2\u3059\u308b\u304b\u306b\u3064\u3044\u3066\u3082\u3001\u305d\u308c\u307e\u3067\u306e\u30e9\u30de\u30eb\u30af\u306e\u8aac\u3068\u306f\u5168\u304f\u5225\u306b\u3001\u907a\u4f1d\u306e\u554f\u984c\u3092\u5341\u5206\u306b\u8003\u616e\u3057\u305fgenetic assimilation\u3068\u3044\u3046\u72ec\u81ea\u306e\u4eee\u8aac\u306b\u3088\u3063\u3066\u8aac\u660e\u3057\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u3053\u308c\u3089\u306eWaddington\u306e\u30a2\u30a4\u30c7\u30a3\u30a2\u306f\u3001\u307e\u3060\u73fe\u4ee3\u306e\u79d1\u5b66\u3067\u8a3c\u660e\u3055\u308c\u3066\u3044\u306a\u3044\u3082\u306e\u304c\u307b\u3068\u3093\u3069\u3002\u3053\u308c\u304b\u3089\u7814\u7a76\u8005\u3092\u76ee\u6307\u3059\u65b9\u306b\u306f\u3001\u539f\u6587\u3067\u662f\u975e\u8aad\u3093\u3067\u3044\u305f\u3060\u304d\u305f\u3044\u4e00\u518a\u3067\u3059\u3002\u73fe\u4ee3\u306e\u30b7\u30b9\u30c6\u30e0\u30ba\u30d0\u30a4\u30aa\u30ed\u30b8\u30fc\u306e\u6e90\u6d41\u3092\u4f5c\u3063\u305fConrad Hal Waddington\u306e\u540d\u8457\u3067\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<h2>\u73fe\u4ee3\u793e\u4f1a\u3068\u30b9\u30c8\u30ec\u30b9\u3000by Hans Selye (1978)<\/h2>\n<p style=\"text-align: left\">\u300c\u30b9\u30c8\u30ec\u30b9\u5b66\u8aac\u300d\u3092\u63d0\u5531\u3057\u3001\u30ce\u30fc\u30d9\u30eb\u8cde\u5019\u88dc\u8005\u3068\u3082\u306a\u3063\u305fHans Selye\u306b\u3088\u308b\u3001\u30b9\u30c8\u30ec\u30b9\u304b\u3089\u5065\u5eb7\u3001\u793e\u4f1a\u751f\u6d3b\u3001\u305d\u3057\u3066\u9032\u5316\u3084\u5bff\u547d\u306b\u3044\u305f\u308b\u307e\u3067\u3001\u3048\u3050\u308b\u3088\u3046\u306a\u6df1\u3044\u6d1e\u5bdf\u304c\u8a18\u3055\u308c\u305f\u4e00\u518a\u3002RNA\u30ef\u30af\u30c1\u30f3\u306e\u958b\u767a\u8005\u306e\u4e00\u4eba\u3067\u3042\u308b\u3001Katalin Karik\u00f3\u6c0f\u304c\u30d0\u30a4\u30d6\u30eb\u3068\u4ef0\u3050\u672c\u300c\u30b9\u30c8\u30ec\u30b9\u3068\u751f\u547d\u300d\u306e\u4f5c\u8005\u304c\u66f8\u3044\u305f\u672c\u3067\u3001\u300c\u30b9\u30c8\u30ec\u30b9\u3068\u751f\u547d\u300d\u3088\u308a\u3082\u3001\u79d1\u5b66\u7684\u77e5\u898b\u306b\u3064\u3044\u3066\u8a73\u3057\u304f\u3001\u307e\u305f\u5e45\u5e83\u304f\u66f8\u3044\u3066\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u672c\u306b\u51fa\u3066\u304f\u308b\u300cReacton\u300d\u306f\u3001\u30b9\u30c8\u30ec\u30b9\u3068\u5bff\u547d\u3001\u9032\u5316\u3092\u3064\u306a\u3050\u3001\u8d85\u5206\u5b50\u7684\u6982\u5ff5\u3068\u3057\u3066\u63cf\u304b\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u73fe\u5728\u306e\u79d1\u5b66\u3067\u306f\u307e\u3060\u89e3\u660e\u3055\u308c\u3066\u3044\u306a\u3044\u3001\u672a\u6765\u306e\u7814\u7a76\u306b\u306a\u3063\u3066\u3044\u304f\u306e\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002Hans Selye\u306e\u672c\u306f\u3001\u3069\u3061\u3089\u3082\u606f\u3092\u5451\u3080\u3088\u3046\u306a\u3059\u3070\u3089\u3057\u3044\u6d1e\u5bdf\u529b\u3067\u3001\u5fc3\u306e\u5965\u5e95\u304b\u3089\u611f\u52d5\u3057\u307e\u3059\u3002\u300c\u79d1\u5b66\u306f\u4e00\u7a2e\u306e\u81ea\u5df1\u8868\u73fe\u3067\u3042\u308b\u300d\u3068\u3044\u3046\u8a00\u8449\u306b\u306f\u3001\u6df1\u304f\u5171\u611f\u3057\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u3053\u306e\u3042\u3068\u306f\u3001\u7814\u7a76\u5ba4\u306e\u7814\u7a76\u306b\u76f4\u63a5\u95a2\u9023\u3057\u3066\u3044\u308b\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u304c\u3001\u79d1\u5b66\u306b\u901a\u3058\u308b\u672c\u3002<\/p>\n<h2>\u52d8\u306e\u7814\u7a76\u3000by\u00a0 \u9ed2\u7530\u4eae\u3000(1933)<\/h2>\n<p style=\"text-align: left\">\u5408\u6c17\u9053\u306e\u591a\u7530\u5b8f\u5e2b\u7bc4\u304b\u3089\u5b66\u3093\u3060\u4e00\u518a\u3002\u4eba\u9593\u306b\u3042\u308b\u300c\u52d8\u300d\u304c\u3069\u3053\u304b\u3089\u6765\u308b\u306e\u304b\u3001\u3092\u30c6\u30fc\u30de\u306b\u3001\u897f\u6d0b\u306e\u79d1\u5b66\u3084\u54f2\u5b66\u3068\u3001\u6771\u6d0b\u306e\u5b66\u554f\u304c\u9577\u3044\u6b74\u53f2\u306e\u4e2d\u3067\u5f97\u3066\u304d\u305f\u5171\u901a\u306e\u77e5\u898b\u304b\u3089\u3001\u4eba\u9593\u306e\u672c\u8cea\u306b\u8feb\u308b\u4e0d\u673d\u306e\u540d\u4f5c\u3002\u7d9a\u7de8\u306e\u6700\u5f8c\u306e\u300c\u7d50\u3073\u300d\u306f\u3001\u4ed5\u4e8b\u3084\u5927\u5b66\u3067\u306e\u5b66\u3073\u3001\u305d\u3057\u3066\u4eba\u751f\u306e\u610f\u7fa9\u306b\u3064\u3044\u3066\u3068\u3066\u3082\u660e\u6670\u304b\u3064\u6df1\u3044\u6d1e\u5bdf\u304c\u306a\u3055\u308c\u3066\u304a\u308a\u3001\u5927\u5b66\u751f\u306b\u3082\u3001\u5927\u5b66\u751f\u3067\u306a\u3044\u65b9\u306b\u3082\u3001\u305c\u3072\u3053\u3053\u307e\u3067\u3058\u3063\u304f\u308a\u8aad\u3093\u3067\u3044\u305f\u3060\u304d\u305f\u3044\u3067\u3059\u3002<\/p>\n<p>\u300c\u4eba\u683c\u306e\u9676\u51b6\u3068\u306f\u3001\u7269\u3092\u6b63\u3057\u304f\u8996\u308b\u8aa0\u610f\u3092\u78ba\u7acb\u3057\u3001\u3053\u308c\u3092\u57f9\u990a\u3059\u308b\u3053\u3068\u306b\u5e30\u7740\u3059\u308b\u300d<\/p>\n<p>(\u300c\u52d8\u306e\u7814\u7a76\u300d\u3088\u308a)<\/p>\n<p>&nbsp;<\/p>\n<h2>\u30ac\u30a6\u30c7\u30a3\u306e\u4f1d\u8a00\u3000by \u5916\u5c3e\u60a6\u90ce\u3000(2006)<\/h2>\n<p style=\"text-align: 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