{"id":526,"date":"2015-08-25T15:41:54","date_gmt":"2015-08-25T06:41:54","guid":{"rendered":"http:\/\/www-p.cc.ocha.ac.jp\/chem-ogawa\/?page_id=526"},"modified":"2015-08-25T15:41:54","modified_gmt":"2015-08-25T06:41:54","slug":"kenkyu_4","status":"publish","type":"page","link":"http:\/\/www-p.sci.ocha.ac.jp\/chem-ogawa\/theme\/kenkyu_4.html","title":{"rendered":"4. \u82b1\u7c89\u30a2\u30ec\u30eb\u30b2\u30f3\u3068\u7cd6\u9396"},"content":{"rendered":"

\u30b9\u30ae\u82b1\u7c89\u75c7\u3068\u7cd6\u9396\u6297\u539f<\/h2>\n

\u5897\u52a0\u3059\u308b\u82b1\u7c89\u75c7\u306f\u3001\u30b9\u30c8\u30ec\u30b9\u3084\u4ea4\u901a\u91cf\u3068\u306e\u95a2\u4fc2\u3082\u793a\u5506\u3055\u308c\u3001\u73fe\u4ee3\u75c5\u306e\u3072\u3068\u3064\u3068\u3044\u3048\u308b\u3067\u3057\u3087\u3046\u3002\u65e5\u672c\u306e\u82b1\u7c89\u30a2\u30ec\u30eb\u30ae\u30fc\u306e\u4e2d\u3067\u306f\u3001\u30b9\u30ae\u82b1\u7c89\u75c7\u306e\u60a3\u8005\u4eba\u53e3\u304c\u6700\u3082\u591a\u304f\u3001\u65e5\u672c\u30b9\u30ae\uff08 Cryptomeria japonica \uff09\u304b\u3089\u98db\u6563\u3059\u308b\u82b1\u7c89\u306e\u4e3b\u8981\u30a2\u30ec\u30eb\u30b2\u30f3\u3068\u3057\u3066\u3001\u3059\u3067\u306b Cryj \u2160\u3001 Cryj \u2161\u304c\u540c\u5b9a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u3046\u3061 Cryj \u2160\u306f\u7d04\uff16\uff5e\uff18\uff05\u306e\u7cd6\u3092\u542b\u3080\u7cd6\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3059\u3002\u690d\u7269\u6027\u306e\u30a2\u30ec\u30eb\u30b2\u30f3\u306b\u306f\u7cd6\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u591a\u3044\u3053\u3068\u304b\u3089\u3001\u7cd6\u9396\u304c\u30a2\u30ec\u30eb\u30ae\u30fc\u306e\u539f\u56e0\u3067\u306f\u306a\u3044\u304b\u3068\u3001\u4eca\u3067\u3082\u4e16\u754c\u4e2d\u3067\u7591\u308f\u308c\u3066\u3044\u307e\u3059\u3002\u79c1\u9054\u306f\u307e\u305a\u3001\u30b9\u30ae\u82b1\u7c89\u304b\u3089 Cryj \u2160\u3092\u7cbe\u88fd\u3057\u3001\u305d\u306e\u7cd6\u9396\u69cb\u9020\u3092\u5fae\u91cf\u3067\u89e3\u6790\u3057\u307e\u3057\u305f\u3002 Cryj \u2160\u306e\u4e3b\u8981\u7cd6\u9396\u306f\u3001\u690d\u7269\u7cd6\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u7279\u6709\u306a\u30b3\u30a2\u69cb\u9020\u3068\u5074\u9396\u3092\u542b\u3080\uff12\u672c\u9396\u8907\u5408\u578b\u7cd6\u9396\u3067\u3057\u305f\u3002
\n\u3055\u3066 Cryj \u2160\u3092\u30a6\u30b5\u30ae\u306b\u6ce8\u5c04\u3057\u3066\u3064\u304f\u3089\u305b\u305fIgG\u306f\u7cd6\u9396\u3092\u8a8d\u8b58\u3057\u3066\u7d50\u5408\u3059\u308b\u3053\u3068\u304cELISA\u6cd5\u3067\u308f\u304b\u308a\u307e\u3057\u305f\u3002\u3053\u306e\u3088\u3046\u306a\u6297\u4f53\u306f\u3001\u5171\u901a\u306a\u7cd6\u9396\u90e8\u5206\u3092\u3082\u3064\u3001\u4ed6\u306e\u591a\u304f\u306e\u690d\u7269\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u3082\u4ea4\u5dee\u53cd\u5fdc\u3057\u307e\u3059\u3002\u3068\u3053\u308d\u304c\u30a2\u30ec\u30eb\u30ae\u30fc\u60a3\u8005\u306e\u8840\u6e05\u306b\u542b\u307e\u308c\u308bIgE\u306f Cryj \u2160\u306e\u7cd6\u9396\u3068\u306f\u53cd\u5fdc\u305b\u305a\u3001 Cryj \u2160\u306e\u7cd6\u9396\u306f\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u60a3\u8005IgG\u306e\u4e3b\u306a\u30a8\u30d4\u30c8\u30fc\u30d7\u3067\u306f\u306a\u3044\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f 1)<\/sup> \u3002\u3053\u308c\u307e\u3067\u306b\u7cd6\u9396\u90e8\u5206\u304cIgE\u30a8\u30d4\u30c8\u30fc\u30d7\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u305f\u30df\u30c4\u30d0\u30c1\u6bd2\u30db\u30b9\u30db\u30ea\u30d1\u30fc\u30bcA2\u3001\u30aa\u30ea\u30fc\u30d6\u82b1\u7c89\u30a2\u30ec\u30eb\u30b2\u30f3\u306a\u3069\u3068\u7570\u306a\u308a\u3001 Cryj \u2160\u3067\u306fIgE\u306e\u4e3b\u8981\u306a\u30a8\u30d4\u30c8\u30fc\u30d7\u306f\u7cd6\u9396\u3067\u306f\u306a\u304f\u3001\u30b3\u30f3\u30db\u30e1\u30fc\u30b7\u30e7\u30f3\u4f9d\u5b58\u7684\u306a\u30da\u30d7\u30c1\u30c9\u306b\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u3057\u304b\u3057\u4ed6\u306e \u82b1\u7c89\u75c7\u3067\u306f\u5c11\u6570\u306e\u60a3\u8005\u3067\u3059\u304c\u3001\u7cd6\u9396\u3068\u53cd\u5fdc\u3059\u308bIgE\u3092\u3082\u3064\u4eba\u3082\u3044\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u30a2\u30ec\u30eb\u30b2\u30f3\u7cd6\u9396\u306e\u6297\u539f\u6027\u306b\u3064\u3044\u3066\u306f\u3001\u500b\u4eba\u5dee\u306e\u4ed6\u306b\u5730\u57df\u5dee\u3084\u4eba\u7a2e \u5dee\u3082\u8003\u3048\u3089\u308c\u3001\u3055\u3089\u306b\u591a\u304f\u306e\u30c7\u30fc\u30bf\u304c\u5fc5\u8981\u3060\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002IgE\u304c\u7d50\u5408\u3059\u308b\u7cd6\u9396\u30a8\u30d4\u30c8\u30fc\u30d7\u69cb\u9020\u3001\u5929\u7136\u304a\u3088\u3073\u98df\u7269\u30a2\u30ec\u30eb\u30b2\u30f3\u306b\u304a\u3051\u308b\u5206\u5e03\u3084\u3001\u6297\u7cd6\u9396\u6297\u4f53\u306e \u751f\u3058\u308b\u6a5f\u69cb\u3082\u8208\u5473\u6df1\u3044\u3082\u306e\u3067\u3059 2,3)<\/sup> \u3002<\/p>\n

1)<\/i> Ogawa H., et al., Glycoconj. J.<\/i> , 13,555-566, (1996)
\nStructures and contribution to the antigenicity of oligosaccharides of Japanese cedar (Cryptomeria japonica) pollen allergen Cry j I: relationship between the structures and antigenic epitopes of plant N-linked complex-type glycans<\/a><\/p>\n

2)<\/i> Ueda H. and Ogawa H., Trends in Glycosci. Glycotechnol. <\/i> , 11(62), 413-428, (1999)
\nGlycobiology of the Plant Glycoprotein Epitope: Structure, Immunogenicity and Allergenicity of Plant Glycotopes. <\/a><\/p>\n

3)<\/i> Ogawa H., et al., J. Appl. Glycosci.<\/i> , 50, 327-331, (2003)
\nCharacterization of Carbohydrate Epitope of Pollen and Wheat Allergens<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

\u30b9\u30ae\u82b1\u7c89\u75c7\u3068\u7cd6\u9396\u6297\u539f \u5897\u52a0\u3059\u308b\u82b1\u7c89\u75c7\u306f\u3001\u30b9\u30c8\u30ec\u30b9\u3084\u4ea4\u901a\u91cf\u3068\u306e\u95a2\u4fc2\u3082\u793a\u5506\u3055\u308c\u3001\u73fe\u4ee3\u75c5\u306e\u3072\u3068\u3064\u3068\u3044\u3048\u308b\u3067\u3057\u3087\u3046\u3002\u65e5\u672c\u306e\u82b1\u7c89\u30a2\u30ec\u30eb\u30ae\u30fc\u306e\u4e2d\u3067\u306f\u3001\u30b9\u30ae\u82b1\u7c89\u75c7\u306e\u60a3\u8005\u4eba\u53e3\u304c\u6700\u3082\u591a\u304f\u3001\u65e5\u672c\u30b9\u30ae\uff08 Cryptomeria japonic … \u7d9a\u304d\u3092\u8aad\u3080 →<\/span><\/a><\/p>\n","protected":false},"author":17,"featured_media":0,"parent":14,"menu_order":4,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-526","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"http:\/\/www-p.sci.ocha.ac.jp\/chem-ogawa\/wp-json\/wp\/v2\/pages\/526","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www-p.sci.ocha.ac.jp\/chem-ogawa\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/www-p.sci.ocha.ac.jp\/chem-ogawa\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/www-p.sci.ocha.ac.jp\/chem-ogawa\/wp-json\/wp\/v2\/users\/17"}],"replies":[{"embeddable":true,"href":"http:\/\/www-p.sci.ocha.ac.jp\/chem-ogawa\/wp-json\/wp\/v2\/comments?post=526"}],"version-history":[{"count":0,"href":"http:\/\/www-p.sci.ocha.ac.jp\/chem-ogawa\/wp-json\/wp\/v2\/pages\/526\/revisions"}],"up":[{"embeddable":true,"href":"http:\/\/www-p.sci.ocha.ac.jp\/chem-ogawa\/wp-json\/wp\/v2\/pages\/14"}],"wp:attachment":[{"href":"http:\/\/www-p.sci.ocha.ac.jp\/chem-ogawa\/wp-json\/wp\/v2\/media?parent=526"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}