{"id":524,"date":"2015-08-25T15:40:13","date_gmt":"2015-08-25T06:40:13","guid":{"rendered":"http:\/\/www-p.cc.ocha.ac.jp\/chem-ogawa\/?page_id=524"},"modified":"2015-08-25T15:40:13","modified_gmt":"2015-08-25T06:40:13","slug":"kenkyu_3","status":"publish","type":"page","link":"http:\/\/www-p.sci.ocha.ac.jp\/chem-ogawa\/theme\/kenkyu_3.html","title":{"rendered":"3. \u7d44\u7e54\u4fee\u5fa9\u3068\u7cd6\u9396"},"content":{"rendered":"<h2>\u7cd6\u9396\u5909\u5316\u306b\u3088\u3063\u3066\u8abf\u7bc0\u3055\u308c\u308b\u30d3\u30c8\u30ed\u30cd\u30af\u30c1\u30f3\u306e\u30b3\u30e9\u30fc\u30b2\u30f3\u7d50\u5408\u6027<\/h2>\n<p>\u30d3\u30c8\u30ed\u30cd\u30af\u30c1\u30f3\u306f\u809d\u81d3\u3067\u7523\u751f\u3055\u308c\u3001\u8840\u6db2\u3084\u7d50\u5408\u7d44\u7e54\u4e2d\u306b\u3042\u3063\u3066\u3001\u8840\u6db2 \u51dd\u56fa\u7cfb\u3001\u7dda\u6eb6\u7cfb\u3001\u88dc\u4f53\u514d\u75ab\u7cfb\u306a\u3069\u3055\u307e\u3056\u307e\u306a\u8abf\u7bc0\u306b \u304b\u304b\u308f\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u305f\u3068\u3048\u3070\u7d30\u80de\u57f9\u990a\u3067\u30a6\u30b7\u80ce\u5150\u8840\u6e05\u3092\u52a0\u3048\u307e\u3059\u304c\u3001\u305d\u306e\u4e2d\u306e\u5fae\u91cf\u306e\u30d3\u30c8\u30ed\u30cd\u30af\u30c1\u30f3\u304c\u7d30\u80de\u306e\u63a5\u7740\u4f38\u5c55\u306b\u91cd\u8981\u3067\u3059\u3002\u3067\u3082\u8a66\u9a13\u7ba1\u306e\u4e2d\u3067 \u6d3b\u6027\u3092\u793a\u3057\u3066\u3082\u3001\u751f\u4f53\u5185\u3067\u306e\u672c\u5f53\u306e\u6a5f\u80fd\u306f\u307e\u3060\u5b8c\u5168\u306b\u308f\u304b\u3063\u3066\u306f\u3044\u307e\u305b\u3093\u3002\u79c1\u9054\u306f\u3053\u308c\u307e\u3067\u3001\u30d3\u30c8\u30ed\u30cd\u30af\u30c1\u30f3\u306e\u7cd6\u9396\u3084\u30bf\u30f3\u30d1\u30af\u90e8\u5206\u306e\u69cb\u9020\u89e3\u6790\u3092\u884c\u3044\u307e\u3057\u305f\u304c\u3001 \u8fd1\u5e74\u3001\u518d\u751f\u809d\u30e9\u30c3\u30c8\u306e\u8840\u6db2\u306b\u542b\u307e\u308c\u308b\u30d3\u30c8\u30ed\u30cd\u30af\u30c1\u30f3\u3092\u8abf\u3079\u308b\u6a5f\u4f1a\u306b\u6075\u307e\u308c\u307e\u3057\u305f\u3002<\/p>\n<p>\u809d\u81d3\u306f\u30011\/3\u4ee5\u4e0b\u3092\u624b\u8853\u3067\u5207\u9664\u3059\u308b\u3068\u3001\uff11\uff10\u65e5\u307b\u3069\u3067 \u5143\u306e\u5927\u304d\u3055\u306b\u307e\u3067\u6210\u9577\u3059\u308b\u3068\u3044\u3046\u9a5a\u304f\u3079\u304d\u518d\u751f\u80fd\u529b\u3092\u3082\u3063\u3066\u3044\u307e \u3059\u3002\u518d\u751f\u4e2d\u306e\u809d\u81d3\u304c\u3064\u304f\u308b\u30d3\u30c8\u30ed\u30cd\u30af\u30c1\u30f3\u306f\u3001\u7cd6\u9396\u306e\u91cf\u3068\u69cb\u9020\u304c\u975e\u5e38\u306b\u5909\u5316\u3057\u3001\u540c\u6642\u306b\u30b3\u30e9\u30fc\u30b2\u30f3\u7d50\u5408\u6d3b\u6027\u304c\u6b63\u5e38\u30e9\u30c3\u30c8\u306e\u6570\u500d\u306b\u5897\u5f37\u3057\u3066\u304a\u308a\u307e\u3057\u305f\u3002\u3057\u304b\u3082\u3001 \u518d\u751f\u809d\u306e\u7523\u751f\u3059\u308b\u30d3\u30c8\u30ed\u30cd\u30af\u30c1\u30f3\u3060\u3051\u3067\u306f\u306a\u304f\u3001\u30b7\u30e3\u30e0\u624b\u8853\uff08\u958b\u8179\u3057\u3066\u809d\u81d3\u3092\u5207\u9664\u305b\u305a\u306b\u3001\u5143\u3069\u304a\u308a\u7e2b\u5408\u3059\u308b\uff09\u3092\u884c\u3063\u305f\u30e9\u30c3\u30c8\u306e\u30d3\u30c8\u30ed\u30cd\u30af\u30c1\u30f3\u3067\u3082\u3001\u7a0b\u5ea6\u306f\u3084 \u3084\u4f4e\u3044\u306a\u304c\u3089\u3001\u540c\u3058\u5909\u5316\u304c\u8d77\u304d\u3066\u3044\u307e\u3057\u305f\u3002\u4ee5\u524d\u306b\u3001\u8a66\u9a13\u7ba1\u306e\u306a\u304b\u3067\u9175\u7d20\u3092\u4f7f\u3063\u3066\u3001\u30d3\u30c8\u30ed\u30cd\u30af\u30c1\u30f3\u304b\u3089\u4eba\u5de5\u7684\u306b\u7cd6\u9396\u3092\u9664\u304f\u3068\u4f55\u304c\u5909\u308f\u308b\u304b\u3092\u8abf\u3079\u305f\u3053\u3068\u306f\u3042\u308a \u307e\u3057\u305f <sup>1)<\/sup> \u304c\u3001\u751f\u4f53\u5185\u3067\u5b9f\u969b\u306b\u3088\u304f\u4f3c\u305f\u5909\u5316\u304c\u8d77\u304d\u3066\u3044\u308b\u4f8b\u3092\u898b\u3064\u3051\u308b\u3053\u3068\u304c\u3067\u304d\u3001\u3068\u3066\u3082\u5b09\u3057\u304f\u611f\u3058\u307e\u3057\u305f\u3002\u7d44\u7e54\u306e\u518d\u751f\u3084\u50b7\u53e3\u306e\u4fee \u5fa9\u306b\u304a\u3044\u3066\u3001\u30d3\u30c8\u30ed\u30cd\u30af\u30c1\u30f3\u304c\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3059\u306e\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002\u809d\u5207\u9664\u306e\u624b\u8853\u5f8c\u3067\u306f\u3001\u809d\u81d3\u306e\u7523\u751f\u3059\u308b\u7cd6\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u91cf\u304c\u4e00\u65e6\u6e1b\u5c11\u3057\u3001\u30d3\u30c8\u30ed\u30cd\u30af\u30c1\u30f3\u306e \u91cf\u3082\u534a\u5206\u4ee5\u4e0b\u306b\u306a\u308a\u307e\u3059\u306e\u3067\u3001\u30d3\u30c8\u30ed\u30cd\u30af\u30c1\u30f3\u3067\u306f\u7cd6\u9396\u3092\u4e2d\u5fc3\u3068\u3057\u305f\u8cea\u7684\u306a\u5909\u5316\u306b\u3088\u3063\u3066\u3001\u91cf\u306e\u4f4e\u4e0b\u3092\u88dc\u3046\u3053\u3068\u3082\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u3053\u306e\u3088\u3046\u306a\u4f8b\u304c\u898b\u3044\u3060\u3055\u308c\u305f\u3053 \u3068\u304b\u3089\u3001\u300c\u6025\u6027\u671f\u306e\u7cd6\u9396\u3068\u7d44\u7e54\u4fee\u5fa9\u306e\u95a2\u4fc2\u300d\u306b\u8208\u5473\u3092\u3082\u3061\u7814\u7a76\u3092\u9032\u3081\u3066\u3044\u307e\u3059 <sup>2\uff5e4)<\/sup> \u3002<\/p>\n<p>\u809d\u661f\u7d30\u80de\u306f\u3001\u809d\u969c\u5bb3\u6642\u306b\u6d3b\u6027\u5316\u3055\u308c\u3001\u7d30\u80de\u5916\u30de\u30c8\u30ea\u30c3\u30af\u30b9\u5206\u5b50\u3092\u7523\u751f\u3057\u3066\u7d44\u7e54\u518d\u5f62\u6210\u306b\u95a2\u308f\u308b\u7d30\u80de\u3067\u3059\u3002\u30e9\u30c3\u30c8\u809d\u518d\u751f\u521d\u671f\u306e\u30d3\u30c8\u30ed\u30cd\u30af\u30c1\u30f3\u57fa\u8cea\u4e0a\u3067\u306f\u3001\u809d\u661f\u7d30\u80de\u306e\u904e\u5270\u306a\u6d3b\u6027\u5316\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f<sup> 5)<\/sup> \u3002\u30d3\u30c8\u30ed\u30cd\u30af\u30c1\u30f3\u306e\u7cd6\u9396\u8abf\u7bc0\u6a5f\u69cb\u306f\u661f\u7d30\u80de\u306e\u6d3b\u6027\u5316\u5236\u5fa1\u3092\u901a\u3058\u3066\u3001\u904e\u5270\u306a\u30de\u30c8\u30ea\u30c3\u30af\u30b9\u7523\u751f\u306b\u3088\u308b\u809d\u7dda\u7dad\u5316\u306e\u767a\u75c7\u3092\u6291\u5236\u3059\u308b\u3057\u304f\u307f\u3067\u306f\u306a\u3044\u304b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n<ol>\n<li>Yoneda A., et al., <i>Biochemistry<\/i> , 37(18), 6351-6360, (1998)<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed?term=Biochemistry%2C%2037%2C18%2C6351-6360%2C%20Yoneda%20A.%2C%20et%20al.\">Characterization of the Ligand Binding Activities of Vitronectin:Interaction of Vitronectin with Lipids and Identification of the Binding Domains for Various Ligands Using Recombinant Domains <\/a><\/li>\n<li>Uchibori-Iwaki H., et al., <i>Glycobiology<\/i> , 10, 865-874, (2000)<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed?term=Glycobiology%2C%2010%2C%20865-874%2C%20%282000%29\">The changes in glycosylation after partial hepatectomy enhance collagen binding of vitronectin in plasma <\/a><\/li>\n<li>\u00a0Sano, K., et al., <i>Glycobiology<\/i> , 17(7), 784-794, (2007).<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed?term=Glycobiology%2C%2017%287%29%2C%20784-794%2C%20%282007%29\">Changes in glycosylation of vitronectin modulates multimerization and collagen binding during liver regeneration <\/a><\/li>\n<li>Sano, K., et al. <i>Carbohyd. Res.<\/i> , 343, 2329-2335, (2008).<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed?term=Carbohyd.%20Res.%2C%20343%2C%202329-2335%2C%20%282008%29\">Glycosylation and ligand-binding activities of rat plasma fibronectin during liver regeneration after partial hepatectomy <\/a><\/li>\n<li>Sano, K., et al., <i>J. Biol. Chem. <\/i> , 285, 17301-17309, (2010).<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed?term=J.%20Biol.%20Chem.%2C%20285%2C17301-17309\">Survival of Hepatic Stellate Cell during Liver Regeneration is Regulated by the Changes in Glycosylation of Rat Vitronectin especially the Decreased Hypersialylation <\/a><\/li>\n<li>Ogawa H., et al., <i>&#8220;Liver regeneration&#8221;\u3000Baptista, P. ed., InTech <\/i> , Open Access (2012).<br \/>\n<a href=\"http:\/\/www.intechopen.com\/books\/liver-regeneration\/matrix-restructuring-during-liver-regeneration-is-regulated-by-glycosylation-of-the-matrix-glycoprot\">Matrix Restructuring During Liver Regeneration is Regulated by Glycosylation of the Matrix Glycoprotein Vitronectin. <\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>\u7cd6\u9396\u5909\u5316\u306b\u3088\u3063\u3066\u8abf\u7bc0\u3055\u308c\u308b\u30d3\u30c8\u30ed\u30cd\u30af\u30c1\u30f3\u306e\u30b3\u30e9\u30fc\u30b2\u30f3\u7d50\u5408\u6027 \u30d3\u30c8\u30ed\u30cd\u30af\u30c1\u30f3\u306f\u809d\u81d3\u3067\u7523\u751f\u3055\u308c\u3001\u8840\u6db2\u3084\u7d50\u5408\u7d44\u7e54\u4e2d\u306b\u3042\u3063\u3066\u3001\u8840\u6db2 \u51dd\u56fa\u7cfb\u3001\u7dda\u6eb6\u7cfb\u3001\u88dc\u4f53\u514d\u75ab\u7cfb\u306a\u3069\u3055\u307e\u3056\u307e\u306a\u8abf\u7bc0\u306b \u304b\u304b\u308f\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u305f\u3068\u3048\u3070\u7d30\u80de\u57f9\u990a\u3067\u30a6 &hellip; <a href=\"http:\/\/www-p.sci.ocha.ac.jp\/chem-ogawa\/theme\/kenkyu_3.html\">\u7d9a\u304d\u3092\u8aad\u3080 <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":17,"featured_media":0,"parent":14,"menu_order":3,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-524","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"http:\/\/www-p.sci.ocha.ac.jp\/chem-ogawa\/wp-json\/wp\/v2\/pages\/524","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www-p.sci.ocha.ac.jp\/chem-ogawa\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/www-p.sci.ocha.ac.jp\/chem-ogawa\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/www-p.sci.ocha.ac.jp\/chem-ogawa\/wp-json\/wp\/v2\/users\/17"}],"replies":[{"embeddable":true,"href":"http:\/\/www-p.sci.ocha.ac.jp\/chem-ogawa\/wp-json\/wp\/v2\/comments?post=524"}],"version-history":[{"count":0,"href":"http:\/\/www-p.sci.ocha.ac.jp\/chem-ogawa\/wp-json\/wp\/v2\/pages\/524\/revisions"}],"up":[{"embeddable":true,"href":"http:\/\/www-p.sci.ocha.ac.jp\/chem-ogawa\/wp-json\/wp\/v2\/pages\/14"}],"wp:attachment":[{"href":"http:\/\/www-p.sci.ocha.ac.jp\/chem-ogawa\/wp-json\/wp\/v2\/media?parent=524"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}