{"id":520,"date":"2015-08-25T15:03:08","date_gmt":"2015-08-25T06:03:08","guid":{"rendered":"http:\/\/www-p.cc.ocha.ac.jp\/chem-ogawa\/?page_id=520"},"modified":"2015-08-25T15:03:08","modified_gmt":"2015-08-25T06:03:08","slug":"kenkyu_1","status":"publish","type":"page","link":"http:\/\/www-p.sci.ocha.ac.jp\/chem-ogawa\/theme\/kenkyu_1.html","title":{"rendered":"1.\u30b7\u30e5\u30fc\u30c9\u30d7\u30ed\u30c6\u30aa\u30b0\u30ea\u30ab\u30f3"},"content":{"rendered":"<p>\u7cd6\u9396\u6a5f\u80fd\u3092\u89e3\u660e\u3057\u3066\u7814\u7a76\u3084\u533b\u7642\u306b\u5229\u7528\u3059\u308b\u305f\u3081\u3001\u7cd6\u9396\u30d7\u30ed\u30fc\u30d6\u3092\u958b\u767a\u3057\u3066\u3044\u307e\u3059\u3002\u30b7\u30e5\u30fc\u30c9\u30d7\u30ed\u30c6\u30aa\u30b0\u30ea\u30ab\u30f3\uff08\u30b7\u30e5\u30fc\u30c9 PG\uff09\u306f\u3001\u5929\u7136\u306e\u30d7\u30ed\u30c6\u30aa\u30b0\u30ea\u30ab\u30f3\u306e\u5206\u5b50\u69cb\u9020\u3092\u6a21\u5023\u3057\u3066\u3001\u76f4\u9396\u9ad8\u5206\u5b50\u306b\u8907\u6570\u306e\u30b0\u30ea\u30b3\u30b5\u30df\u30ce\u30b0\u30ea\u30ab\u30f3\uff08GAG\uff09\u9396\u3092\u5171\u6709\u7d50\u5408\u3055\u305b\u3066\u3001\u79c1\u9054\u304c\u5275\u6210\u3057\u305f\u4eba\u5de5\u8907\u5408 \u4f53\u5206\u5b50\u3067\u3059\u3002\u305d\u306e\u65b0\u3057\u3044\u69cb\u9020\u306b\u57fa\u3065\u304d\u3001\u30d8\u30d1\u30ea\u30f3\u3092\u7528\u3044\u3066\u8abf\u88fd\u3057\u305f\u30b7\u30e5\u30fc\u30c9PG\u306f\u30b5\u30a4\u30af\u30ed\u30d5\u30a3\u30ea\u30f3A\u306a\u3069\u306eGAG\u7d50\u5408\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u5bfe\u3057\u3066\u5358\u72ec\u306eGAG\u9396\u3068\u306f \u7570\u306a\u308b\u7d50\u5408\u6d3b\u6027\u3092\u793a\u3059\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f <i><sup>1)<\/sup> <\/i> \u3002<\/p>\n<p>\u79c1\u9054\u306f\u30b7\u30e5\u30fc\u30c9PG\u306e\u69cb\u9020\u7684\u7279\u5fb4\u3068\u9855\u8457\u306a\u7d50\u5408\u7279\u6027\u306b\u7740\u773c \u3057\u3001\u7d30\u80de\u819c\u4e0a\u30d7\u30ed\u30c6\u30aa\u30b0\u30ea\u30ab\u30f3\u3092\u5fc5\u8981\u3068\u3059\u308bHIV-1\u30a6\u30a4\u30eb \u30b9\u306e\u521d\u671f\u611f\u67d3\u6a5f\u69cb\u3092\u30d6\u30ed\u30c3\u30af\u3057\u3001\u304b\u3064HIV-1\u306b\u5bfe\u3059\u308b\u5bbf\u4e3b\u306e\u62b5\u6297\u6027\u3092\u56de\u5fa9\u3059\u308b\u52b9\u679c\u3092\u4f75\u305b\u6301\u3064\u611f\u67d3\u963b\u5bb3\u5264\u3068\u3057\u3066\u306e\u5229\u7528\u3092\u76ee\u6307\u3057\u3066\u3044\u307e\u3059\u3002\u5929\u7136\u306e\u30d7\u30ed\u30c6\u30aa\u30b0 \u30ea\u30ab\u30f3\u3092\u30b7\u30df\u30e5\u30ec\u30fc\u30c8\u3057\u305f\u69cb\u9020\u3092\u6301\u3064\u30b7\u30e5\u30fc\u30c9\u30d7\u30ed\u30c6\u30aa\u30b0\u30ea\u30ab\u30f3\u30d7\u30ed\u30fc\u30d6\u306e\u6297\u30a8\u30a4\u30ba\u6d3b\u6027\u3068\u305d\u306e\u5206\u5b50\u6a5f\u69cb\u306b\u3064\u3044\u3066\u3001\u5e73\u621018\uff5e20\u5e74\u5ea6\u306b\u306f\u539a\u751f\u79d1\u7814\u8cbb\u306e\u652f\u63f4\u3092 \u53d7\u3051\u3066\u5171\u540c\u7814\u7a76\u3092\u884c\u3044\u307e\u3057\u305f\u3002<\/p>\n<p><a href=\"http:\/\/www-p.sci.ocha.ac.jp\/chem-ogawa\/wp-content\/uploads\/sites\/10\/2015\/08\/image120423.gif\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-608 colorbox-520\" src=\"http:\/\/www-p.sci.ocha.ac.jp\/chem-ogawa\/wp-content\/uploads\/sites\/10\/2015\/08\/image120423.gif\" alt=\"image120423\" width=\"544\" height=\"315\" \/><\/a><\/p>\n<p>\u305d\u306e\u7814\u7a76\u3067\u79c1\u9054\u306f\u3001\u3055\u307e\u3056\u307e\u306a\u7cd6\u9396\u3092\u7528\u3044\u3066\u30b7\u30e5\u30fc\u30c9\u30d7\u30ed\u30c6\u30aa\u30b0\u30ea\u30ab\u30f3\u3092\u5408\u6210\u3057\u307e\u3057\u305f\u3002\u305d\u308c\u3089\u306e\u6297HIV-1\u6d3b\u6027\u3092\u8abf \u3079\u308b\u4e2d\u3067\u3001\u305d\u308c\u81ea\u4f53\u306f\u5168\u304f\u6d3b\u6027\u3092\u793a\u3055\u306a\u3044\u30c7\u30ad\u30b9\u30c8\u30e9\u30f3\u3084\u4e2d\u6027\u30aa\u30ea\u30b4\u7cd6\u9396\u306a\u3069\u306e\u975e\u786b\u9178\u5316\u7cd6\u985e\u3068\u3001\u30a2\u30df\u30ce\u57fa\u3092\u8907\u6570\u6301\u3064\u76f4\u9396\u9ad8\u5206\u5b50\u3092\u6750\u6599\u3068\u3057\u3066\u7528\u3044\u3066\u30b7\u30e5\u30fc\u30c9\u30d7 \u30ed\u30c6\u30aa\u30b0\u30ea\u30ab\u30f3\u3092\u5408\u6210\u3059\u308b\u3068\u3001\u6975\u3081\u3066\u9ad8\u3044\u6297HIV-1\u6d3b\u6027\u304c\u51fa\u73fe\u3059\u308b\u3053\u3068\u3092\u767a\u898b\u3057\u307e\u3057\u305f <i>2) <\/i> \u3002\u30d8\u30d1\u30ea\u30f3\u3084\u30c7\u30ad\u30b9\u30c8\u30e9\u30f3\u786b\u9178\u306a\u3069\u306e\u786b\u9178\u5316\u591a\u7cd6\u304c\u6297HIV-1\u6d3b\u6027\u3092\u793a\u3059\u3053\u3068\u306f\u4ee5\u524d\u304b\u3089\u77e5\u3089\u308c\u3066\u3044\u307e\u3057\u305f\u304c\u3001\u79c1\u9054\u304c\u5408 \u6210\u3057\u305f\u975e\u786b\u9178\u5316\u7cd6\u985e\uff0d\u30a2\u30df\u30ce\u57fa\u5206\u5b50\u8907\u5408\u4f53\u306f\u3001\u7a2e\u3005\u306e\u85ac\u5264\u8010\u6027\u30a6\u30a4\u30eb\u30b9\u3084\u3001\u81e8\u5e8a\u5206\u96e2\u682a\u306e\u30a6\u30a4\u30eb\u30b9\u306b\u5bfe\u3057\u3066\u3082\u3001\u3053\u308c\u307e\u3067\u77e5\u3089\u308c\u3066\u3044\u308b\u786b\u9178\u5316\u591a\u7cd6\u985e\u4ee5\u4e0a\u306e\u9ad8\u6d3b\u6027 \u3092\u793a\u3057\u307e\u3057\u305f\u3002\u307e\u305f\u3001\u6750\u6599\u304c\u6301\u3063\u3066\u3044\u305f\u7d30\u80de\u306b\u5bfe\u3059\u308b\u6bd2\u6027\u306f\u3001\u8907\u5408\u4f53\u306b\u5408\u6210\u3059\u308b\u3053\u3068\u3067\u8457\u3057\u304f\u4f4e\u6e1b\u3055\u308c\u308b\u3053\u3068\u3082\u308f\u304b\u308a\u307e\u3057\u305f\u3002<\/p>\n<p>\u3053\u306e \u3088\u3046\u306a\u30b7\u30e5\u30fc\u30c9\u30d7\u30ed\u30c6\u30aa\u30b0\u30ea\u30ab\u30f3\u306f\u3001\u786b\u9178\u5316\u591a\u7cd6\u3068\u306f\u7570\u306a\u308b\u4f5c\u7528\u6a5f\u69cb\u3067\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u304c\u3001\u79c1\u9054\u3068\u5171\u540c \u7814\u7a76\u8005\u306e\u5b9f\u9a13\u304b\u3089\u308f\u304b\u3063\u3066\u304d\u307e\u3057\u305f\u3002\u307e\u305f\u3001\u5408\u6210\u3059\u308b\u6750\u6599\u306e\u7cd6\u9396\u3084\u9aa8\u683c\u5206\u5b50\u3092\u53d6\u308a\u63db\u3048\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u69cb\u9020\u3084\u6d3b\u6027\u306e\u7570\u306a\u308b\u30b7\u30e5\u30fc\u30c9\u30d7\u30ed\u30c6\u30aa\u30b0\u30ea\u30ab\u30f3\u3092\u5bb9\u6613\u306b\u5408 \u6210\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u4ee5\u4e0a\u306e\u7814\u7a76\u5185\u5bb9\u306b\u3064\u3044\u3066\u306f\u65b0\u805e\u306b\u53d6\u308a\u4e0a\u3052\u3089\u308c\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f <sup><i>3) <\/i> <\/sup>\u3002<\/p>\n<p>\u65e5\u672c\u3067\u306f\u30a8\u30a4\u30ba \u60a3\u8005\u304c\u5148\u9032\u56fd\u3067\u552f\u4e00\u5897\u52a0\u3057\u3066\u3044\u307e\u3059\u3002\u3055\u3089\u306b\u3001HIV\u30a6\u30a4\u30eb\u30b9\u306f\u5909\u7570\u304c\u65e9\u304f\u3001\u85ac\u5264\u8010\u6027\u3092\u7372\u5f97\u3057\u3084\u3059\u3044\u3053 \u3068\u304b\u3089\u3001\u30a8\u30a4\u30ba\u306e\u52b9\u679c\u7684\u306a\u6cbb\u7642\u306e\u305f\u3081\u306b\u3001\u3053\u308c\u307e\u3067\u3068\u306f\u7570\u306a\u308b\u3057\u304f\u307f\u3067\u611f\u67d3\u3092\u963b\u5bb3\u3059\u308b\u3088\u3046\u306a\u85ac\u5264\u304c\u5f37\u304f\u671b\u307e\u308c\u3066\u3044\u307e\u3059\u3002\u73fe\u5728\u308f\u305f\u3057\u305f\u3061\u306f\u30b7\u30e5\u30fc\u30c9\u30d7\u30ed\u30c6\u30aa\u30b0 \u30ea\u30ab\u30f3\u306e\u6297HIV-1\u6d3b\u6027\u304c\u3069\u3093\u306a\u3057\u304f\u307f\u3067\u767a\u63ee\u3055\u308c\u308b\u306e\u304b\u3092\u3001\u8a73\u3057\u304f\u7814\u7a76\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><i>1)<\/i> Nakagawa K., et al., <i>Glycoconj. J.<\/i> , <strong>26<\/strong> , 1007-1017, (2009)<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed?term=Glycoconj.%20J.%2C%2026%2C%201007-1017%2C%202009\"> Pseudoproteoglycan (pseudoPG) probes that simulate PG macromolecular structure for screening and isolation of PG-binding proteins.<\/a><br \/>\n\u21d2<a href=\"http:\/\/www.springerlink.com\/content\/880502ul280187v5\/\">Full Text<\/a><\/p>\n<p><i>2)<\/i> Nakamura K., et al., <i>Antiviral Res. <\/i> , <strong>10, <\/strong> 865-874, (2012)<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22401805\">Novel anti-HIV-1 activity produced by conjugating unsulfated dextran with polyl-lysine <\/a><br \/>\n\u21d2<a href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0166354212000447\">Full Text<\/a><\/p>\n<p><i>3)<\/i><a href=\"http:\/\/www.nikkan.co.jp\/news\/nkx1020120329aaan.html\">\u65e5\u520a\u5de5\u696d\u65b0\u805e\uff082012\u5e743\u670829\u65e5\u63b2\u8f09\uff09<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u7cd6\u9396\u6a5f\u80fd\u3092\u89e3\u660e\u3057\u3066\u7814\u7a76\u3084\u533b\u7642\u306b\u5229\u7528\u3059\u308b\u305f\u3081\u3001\u7cd6\u9396\u30d7\u30ed\u30fc\u30d6\u3092\u958b\u767a\u3057\u3066\u3044\u307e\u3059\u3002\u30b7\u30e5\u30fc\u30c9\u30d7\u30ed\u30c6\u30aa\u30b0\u30ea\u30ab\u30f3\uff08\u30b7\u30e5\u30fc\u30c9 PG\uff09\u306f\u3001\u5929\u7136\u306e\u30d7\u30ed\u30c6\u30aa\u30b0\u30ea\u30ab\u30f3\u306e\u5206\u5b50\u69cb\u9020\u3092\u6a21\u5023\u3057\u3066\u3001\u76f4\u9396\u9ad8\u5206\u5b50\u306b\u8907\u6570\u306e\u30b0\u30ea\u30b3\u30b5\u30df\u30ce\u30b0\u30ea\u30ab\u30f3\uff08GAG\uff09\u9396\u3092\u5171\u6709 &hellip; <a href=\"http:\/\/www-p.sci.ocha.ac.jp\/chem-ogawa\/theme\/kenkyu_1.html\">\u7d9a\u304d\u3092\u8aad\u3080 <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":17,"featured_media":0,"parent":14,"menu_order":1,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-520","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"http:\/\/www-p.sci.ocha.ac.jp\/chem-ogawa\/wp-json\/wp\/v2\/pages\/520","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www-p.sci.ocha.ac.jp\/chem-ogawa\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/www-p.sci.ocha.ac.jp\/chem-ogawa\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/www-p.sci.ocha.ac.jp\/chem-ogawa\/wp-json\/wp\/v2\/users\/17"}],"replies":[{"embeddable":true,"href":"http:\/\/www-p.sci.ocha.ac.jp\/chem-ogawa\/wp-json\/wp\/v2\/comments?post=520"}],"version-history":[{"count":0,"href":"http:\/\/www-p.sci.ocha.ac.jp\/chem-ogawa\/wp-json\/wp\/v2\/pages\/520\/revisions"}],"up":[{"embeddable":true,"href":"http:\/\/www-p.sci.ocha.ac.jp\/chem-ogawa\/wp-json\/wp\/v2\/pages\/14"}],"wp:attachment":[{"href":"http:\/\/www-p.sci.ocha.ac.jp\/chem-ogawa\/wp-json\/wp\/v2\/media?parent=520"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}